Search Results - "Beharry, Zanna"

Blocking Myristoylation of Src Inhibits Its Kinase Activity and Suppresses Prostate Cancer Progression by Kim, Sungjin, Alsaidan, Omar Awad, Goodwin, Octavia, Li, Qianjin, Sulejmani, Essilvo, Han, Zhen, Bai, Aiping, Albers, Thomas, Beharry, Zanna, Zheng, Y George, Norris, James S, Szulc, Zdzislaw M, Bielawska, Alicja, Lebedyeva, Iryna, Pegan, Scott D, Cai, Houjian

“…Protein -myristoylation enables localization to membranes and helps maintain protein conformation and function. -myristoyltransferases (NMT) catalyze co- or…”
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Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation by Ma, Yongjie, Zha, Junyi, Yang, XiangKun, Li, Qianjin, Zhang, Qingfu, Yin, Amelia, Beharry, Zanna, Huang, Hanwen, Huang, Jiaoti, Bartlett, Michael, Ye, Kaixiong, Yin, Hang, Cai, Houjian

“…Fatty acid metabolism is essential for the biogenesis of cellular components and ATP production to sustain proliferation of cancer cells. Long-chain fatty…”
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Myristoylation of Src kinase mediates Src-induced and high-fat diet–accelerated prostate tumor progression in mice by Kim, Sungjin, Yang, Xiangkun, Li, Qianjin, Wu, Meng, Costyn, Leah, Beharry, Zanna, Bartlett, Michael G., Cai, Houjian

“…Exogenous fatty acids provide substrates for energy production and biogenesis of the cytoplasmic membrane, but they also enhance cellular signaling during…”
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Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases by Xia, Zuping, Knaak, Christian, Ma, Jian, Beharry, Zanna M, McInnes, Campbell, Wang, Wenxue, Kraft, Andrew S, Smith, Charles D

“…The Pim protein kinases are frequently overexpressed in prostate cancer and certain forms of leukemia and lymphoma…”
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Paracrine Fibroblast Growth Factor Initiates Oncogenic Synergy with Epithelial FGFR/Src Transformation in Prostate Tumor Progression by Li, Qianjin, Ingram, Lishann, Kim, Sungjin, Beharry, Zanna, Cooper, Jonathan A., Cai, Houjian

“…Cross talk of stromal-epithelial cells plays an essential role in both normal development and tumor initiation and progression. Fibroblast growth factor…”
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Pim protein kinases regulate energy metabolism and cell growth by Beharry, Zanna, Mahajan, Sandeep, Zemskova, Marina, Lin, Ying-Wei, Tholanikunnel, Baby G, Xia, Zuping, Smith, Charles D, Kraft, Andrew S

“…The serine/threonine Pim kinases are overexpressed in solid cancers and hematologic malignancies and promote cell growth and survival. Here, we find that a…”
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PIM1 Protein Kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells by Zhang, Fengxue, Beharry, Zanna M., Harris, Thurl E., Lilly, Michael B., Smith, Charles D., Mahajan, Sandeep, Kraft, Andrew S.

“…PIM1 is a serine /threonine kinase that has diverse biological roles in cell survival, proliferation and differentiation.   PIM1 has been implicated in early…”
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A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma by Lin, Ying-Wei, Beharry, Zanna M., Hill, Elizabeth G., Song, Jin H., Wang, Wenxue, Xia, Zuping, Zhang, Zhenhua, Aplan, Peter D., Aster, Jon C., Smith, Charles D., Kraft, Andrew S.

“…The serine/threonine Pim kinases are up-regulated in specific hematologic neoplasms, and play an important role in key signal transduction pathways, including…”
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Encapsulating Cas9 into extracellular vesicles by protein myristoylation by Whitley, Joseph Andrew, Kim, Sungjin, Lou, Lei, Ye, Chenming, Alsaidan, Omar Awad, Sulejmani, Essilvo, Cai, Jingwen, Desrochers, Ellison Gerona, Beharry, Zanna, Rickman, Catherine Bowes, Klingeborn, Mikael, Liu, Yutao, Xie, Zhong‐Ru, Cai, Houjian

“…CRISPR/Cas9 genome editing is a very promising avenue for the treatment of a variety of genetic diseases. However, it is still very challenging to encapsulate…”
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Stromal Gli signaling regulates the activity and differentiation of prostate stem and progenitor cells by Li, Qianjin, Alsaidan, Omar A., Rai, Sumit, Wu, Meng, Shen, Huifeng, Beharry, Zanna, Almada, Luciana L., Fernandez-Zapico, Martin E., Wang, Lianchun, Cai, Houjian

“…Interactions between cells in the stroma and epithelium facilitate prostate stem cell activity and tissue regeneration capacity. Numerous molecular signal…”
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Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis by Wu, Meng, Ingram, Lishann, Tolosa, Ezequiel J., Vera, Renzo E., Li, Qianjin, Kim, Sungjin, Ma, Yongjie, Spyropoulos, Demetri D., Beharry, Zanna, Huang, Jiaoti, Fernandez-Zapico, Martin E., Cai, Houjian

“…Although the differentiation of oncogenically transformed basal progenitor cells is one of the key steps in prostate tumorigenesis, the mechanisms mediating…”
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Collaboration of Kras and Androgen Receptor Signaling Stimulates EZH2 Expression and Tumor-Propagating Cells in Prostate Cancer by HOUJIAN CAI, MEMARZADEH, Sanaz, STOYANOVA, Tanya, BEHARRY, Zanna, KRAFT, Andrew S, WITTE, Owen N

“…Elevation of the chromatin repression factor enhancer of zeste homolog (EZH2) is associated with progression and poor prognosis in several human cancers…”
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Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells by Beharry, Zanna, Zemskova, Marina, Mahajan, Sandeep, Zhang, Fengxue, Ma, Jian, Xia, Zuping, Lilly, Michael, Smith, Charles D, Kraft, Andrew S

“…The Pim protein kinases play important roles in cancer development and progression, including prostate tumors and hematologic malignancies. To investigate the…”
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Src family kinases engage differential pathways for encapsulation into extracellular vesicles by Ye, Chenming, Gosser, Cade, Runyon, Ethan Daniel, Zha, Junyi, Cai, Jingwen, Beharry, Zanna, Bowes Rickman, Catherine, Klingeborn, Mikael, Liu, Yutao, Xie, Jin, Cai, Houjian

“…Extracellular vesicles (EVs) are heterogeneous biological nanoparticles secreted by all cell types. Identifying the proteins preferentially encapsulated in…”
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Functional Analysis of Active Site Residues of the Fosfomycin Resistance Enzyme FosA from Pseudomonas aeruginosa by Beharry, Zanna, Palzkill, Timothy

“…The metalloglutathione transferase FosA catalyzes the conjugation of glutathione to carbon-1 of the antibiotic fosfomycin, rendering it ineffective as an…”
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X-ray Crystal Structure of Benzoate 1,2-Dioxygenase Reductase from Acinetobacter sp. Strain ADP1 by Karlsson, Andreas, Beharry, Zanna M., Matthew Eby, D., Coulter, Eric D., Neidle, Ellen L., Kurtz, Donald M., Eklund, Hans, Ramaswamy, S.

“…One of the major processes for aerobic biodegradation of aromatic compounds is initiated by Rieske dioxygenases. Benzoate dioxygenase contains a reductase…”
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Histidine Ligand Protonation and Redox Potential in the Rieske Dioxygenases:  Role of a Conserved Aspartate in Anthranilate 1,2-Dioxygenase by Beharry, Zanna M, Eby, D. Matthew, Coulter, Eric D, Viswanathan, Rathinam, Neidle, Ellen L, Phillips, Robert S, Kurtz, Donald M

“…The Rieske dioxygenase, anthranilate 1,2-dioxygenase, catalyzes the 1,2-dihydroxylation of anthranilate (2-aminobenzoate). As in all characterized Rieske…”
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Characterization and Evolution of Anthranilate 1,2-Dioxygenase from Acinetobacter sp. Strain ADP1 by Eby, D M, Beharry, Z M, Coulter, E D, Kurtz, Jr, D M, Neidle, E L

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Caught in the act: Monitoring O O bond cleavage in Acylperoxoferric cytochrome P450cam to form compound I in real time by Collins, Daniel P., Johnson, Emily, Coulter, Eric D., Beharry, Zanna, Ballou, David P., Dawson, John H.

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Long-Chain Acyl-CoA Synthetase 4-Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway-Independent Prostate Cancer by Ma, Yongjie, Zhang, Xiaohan, Alsaidan, Omar Awad, Yang, Xiangkun, Sulejmani, Essilvo, Zha, Junyi, Beharry, Zanna, Huang, Hanwen, Bartlett, Michael, Lewis, Zachary, Cai, Houjian

“…Androgen deprivation therapy has led to elevated cases of androgen receptor (AR) pathway-independent prostate cancer with dysregulated fatty acid metabolism…”
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