Search Results - "Behar, Vered"
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Scanning Electron Microscopy of Cells and Tissues under Fully Hydrated Conditions
Published in Proceedings of the National Academy of Sciences - PNAS (09-03-2004)“…A capability for scanning electron microscopy of wet biological specimens is presented. A membrane that is transparent to electrons protects the fully hydrated…”
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Journal Article -
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Psammomys Obesus, a Model for Environment-Gene Interactions in Type 2 Diabetes
Published in Diabetes (New York, N.Y.) (01-12-2005)“…Psammomys Obesus , a Model for Environment-Gene Interactions in Type 2 Diabetes Nurit Kaiser 1 , Rafael Nesher 1 , Marc Y. Donath 2 , Merav Fraenkel 1 , Vered…”
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Journal Article Conference Proceeding -
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Photoaffinity Cross-linking Identifies Differences in the Interactions of an Agonist and an Antagonist with the Parathyroid Hormone/Parathyroid Hormone-related Protein Receptor
Published in The Journal of biological chemistry (07-01-2000)“…Analogs of parathyroid hormone (PTH)-related protein (PTHrP), singularly substituted with a photoreactive l - p- benzoylphenylalanine (Bpa) at each of the…”
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Electron Microscopy of Wet Tissues: A Case Study in Renal Pathology
Published in Toxicologic pathology (01-05-2004)“…In this report we introduce wet-tissue scanning electron microscopy, a novel technique for direct imaging of wet tissue samples using backscattered electrons…”
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Role of Glycosylation in Expression and Function of the Human Parathyroid Hormone/Parathyroid Hormone-Related Protein Receptor
Published in Biochemistry (Easton) (10-12-1996)“…Parathyroid hormone (PTH) regulates calcium metabolism through a specific G protein-coupled, seven-transmembrane helix-containing receptor. This receptor also…”
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A new method of wet scanning electron microscopy for the analysis of myelination in EAE mouse model of multiple sclerosis
Published in Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie (01-03-2006)“…Development of effective therapies for multiple sclerosis (MS) is dependent on the advancement of improved tools for evaluation of progression of this disease…”
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A Hexokinase 2 Modulator for Field-Directed Treatment of Experimental Actinic Keratoses
Published in Journal of investigative dermatology (01-12-2018)“…Overexpression of hexokinase 2, and its binding to VDAC1 on the outer mitochondrial membrane of cancer cells, is key to their metabolic reprogramming to…”
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Wet SEM: A Novel Method for Rapid Diagnosis of Brain Tumors
Published in Ultrastructural pathology (01-07-2004)“…The authors present the application of wet SEM for histopathological assessment, a technology for imaging fully hydrated samples at atmospheric pressure in a…”
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Abstract 1725: A bi-functional mechanism of action: Activating the NLRP3 inflammasome and triggering apoptosis in cancer via a HK2-VDAC modulator
Published in Cancer research (Chicago, Ill.) (01-07-2018)“…Abstract Introduction: Cancer cells undergo metabolic reprogramming to enable the efficient conversion of glucose needed for massive cell growth and…”
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1-(sulfonyl)-5-(arylsulfonyl)indoline as activators of the tumor cell specific M2 isoform of pyruvate kinase
Published in Bioorganic & medicinal chemistry letters (15-10-2012)“…Cancer cells preferentially use glycolysis rather than oxidative phosphorylation for their rapid growth. They consume large amount of glucose to produce…”
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Abstract 3219: Changing the metabolism of cancer cells with PKM2 activators - a path to a cancer metabolism drug
Published in Cancer research (Chicago, Ill.) (15-04-2012)“…Abstract Pyruvate kinase (PK) M2 which catalyzes the last step in glycolysis, is the alternative spliced isoform expressed in cancer cells, and a key player in…”
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Abstract 4065: Modulation of cancer metabolism with novel PKM2 activators exerts anti-tumor activity
Published in Cancer research (Chicago, Ill.) (15-04-2011)“…Abstract Cancer cells adapt altered metabolism to enable efficient conversion of glucose into biomass needed for massive cell growth and proliferation. The…”
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Endocytosis of ligand-human parathyroid hormone receptor 1 complexes is protein kinase C-dependent and involves beta-arrestin2. Real-time monitoring by fluorescence microscopy
Published in The Journal of biological chemistry (15-10-1999)“…Endocytosis and intracellular trafficking of the human parathyroid hormone receptor subtype 1 (hPTH1-Rc) and its ligands was monitored independently by…”
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Imaging and Quantitative Analysis of Lipid Droplets as Early Indicators of Metabolic States
Published in Diabetes (New York, N.Y.) (01-06-2005)Get full text
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Direct identification of two contact sites for parathyroid hormone (PTH) in the novel PTH-2 receptor using photoaffinity cross-linking
Published in Endocrinology (Philadelphia) (01-09-1999)“…Direct examination of the interacting sites between PTH and the human PTH2 receptor (PTH2R) was conducted by photoaffinity cross-linking followed by protein…”
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Journal Article -
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A Role for N‐Cadherin in the Development of the Differentiated Osteoblastic Phenotype
Published in Journal of bone and mineral research (01-02-2000)“…Cadherins are a family of cell surface adhesion molecules that play an important role in tissue differentiation. A limited repertoire of cadherins has been…”
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Psammomys obesus, a model for environment-gene interactions in type 2 diabetes
Published in Diabetes (New York, N.Y.) (01-12-2005)“…Type 2 diabetes is characterized by insulin resistance and progressive β-cell failure. Deficient insulin secretion, with increased proportions of insulin…”
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Journal Article -
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The human PTH2 receptor: binding and signal transduction properties of the stably expressed recombinant receptor
Published in Endocrinology (Philadelphia) (01-07-1996)“…We have generated a series of stably transfected HEK-293 cell lines expressing the newly identified alternate human PTH receptor (hPTH2 receptor). This…”
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A Novel Method for "Wet" SEM
Published in Ultrastructural pathology (2004)“…Progress in the processing of wet tissues, without the need of fixation and complex preparation procedures, may facilitate the microscopic examination of…”
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Journal Article -
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Direct Identification of Two Contact Sites for Parathyroid Hormone (PTH) in the Novel PTH-2 Receptor using Photoaffinity Cross-Linking1
Published in Endocrinology (Philadelphia) (01-09-1999)“…Direct examination of the interacting sites between PTH and the human PTH2 receptor (PTH2R) was conducted by photoaffinity cross-linking followed by protein…”
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