Search Results - "Behar, Samuel M."

CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection by Lu, Yu-Jung, Barreira-Silva, Palmira, Boyce, Shayla, Powers, Jennifer, Cavallo, Kelly, Behar, Samuel M.

“…CD4 T cells are essential for immunity to tuberculosis because they produce cytokines, including interferon-γ. Whether CD4 T cells act as “helper” cells to…”
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Evasion of innate immunity by Mycobacterium tuberculosis : is death an exit strategy? by Behar, Samuel M, Remold, Heinz G, Divangahi, Maziar

“…In this Opinion article, the authors describe how Mycobacterium tuberculosis infection of host macrophages affects the balance of host lipid mediators and, in…”
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Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing by Zhang, Yanjia J., Reddy, Manchi C., Ioerger, Thomas R., Rothchild, Alissa C., Dartois, Veronique, Schuster, Brian M., Trauner, Andrej, Wallis, Deeann, Galaviz, Stacy, Huttenhower, Curtis, Sacchettini, James C., Behar, Samuel M., Rubin, Eric J.

“…Bacteria that cause disease rely on their ability to counteract and overcome host defenses. Here, we present a genome-scale study of Mycobacterium tuberculosis…”
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In search of a new paradigm for protective immunity to TB by Nunes-Alves, Cláudio, Booty, Matthew G., Carpenter, Stephen M., Jayaraman, Pushpa, Rothchild, Alissa C., Behar, Samuel M.

“…Author Manuscript Clinical trials of vaccines against Mycobacterium tuberculosis are well under way and results are starting to come in. Some of these results…”
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Heterogeneity in lung macrophage control of Mycobacterium tuberculosis is modulated by T cells by Lai, Rocky, Williams, Travis, Rakib, Tasfia, Lee, Jinhee, Behar, Samuel M.

“…Following Mycobacterium tuberculosis infection, alveolar macrophages are initially infected but ineffectively restrict bacterial replication. The distribution…”
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Emerging Tim-3 functions in antimicrobial and tumor immunity by Sakuishi, Kaori, Jayaraman, Pushpa, Behar, Samuel M, Anderson, Ana C, Kuchroo, Vijay K

“…T cell immunoglobulin-3 (Tim-3) has been identified as a marker of differentiated interferon-γ-producing CD4+ T helper type 1 and CD8+ T cytotoxic type 1…”
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Efferocytosis Is an Innate Antibacterial Mechanism by Martin, Constance J., Booty, Matthew G., Rosebrock, Tracy R., Nunes-Alves, Cláudio, Desjardins, Danielle M., Keren, Iris, Fortune, Sarah M., Remold, Heinz G., Behar, Samuel M.

“…Mycobacterium tuberculosis persists within macrophages in an arrested phagosome and depends upon necrosis to elude immunity and disseminate. Although apoptosis…”
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TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection by Jayaraman, Pushpa, Jacques, Miye K, Zhu, Chen, Steblenko, Katherine M, Stowell, Britni L, Madi, Asaf, Anderson, Ana C, Kuchroo, Vijay K, Behar, Samuel M

“…While T cell immunity initially limits Mycobacterium tuberculosis infection, why T cell immunity fails to sterilize the infection and allows recrudescence is…”
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Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis by Divangahi, Maziar, Desjardins, Danielle, Nunes-Alves, Cláudio, Remold, Heinz G, Behar, Samuel M

“…Virulent Mycobacterium tuberculosis inhibits apoptosis of infected macrophages. Behar and co-workers show that inhibition of apoptosis prevents…”
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iNKT cell production of GM-CSF controls Mycobacterium tuberculosis by Rothchild, Alissa C., Jayaraman, Pushpa, Alves, Cláudio, Behar, Samuel M.

“…Invariant natural killer T (iNKT) cells are activated during infection, but how they limit microbial growth is unknown in most cases. We investigated how iNKT…”
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Use of the Human Granulysin Transgenic Mice To Evaluate the Role of Granulysin Expression by CD8 T Cells in Immunity To Mycobacterium tuberculosis by Thakur, Preeti, Sutiwisesak, Rujapak, Lu, Yu-Jung, Behar, Samuel M

“…The cytotoxic granules of human NK and CD8 T cells contain the effector molecule granulysin. Although studies indicate that granulysin is bactericidal to…”
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Mycobacterium tuberculosis-specific CD4+ and CD8+ T cells differ in their capacity to recognize infected macrophages by Yang, Jason D, Mott, Daniel, Sutiwisesak, Rujapak, Lu, Yu-Jung, Raso, Fiona, Stowell, Britni, Babunovic, Greg Hunter, Lee, Jinhee, Carpenter, Steve M, Way, Sing Sing, Fortune, Sarah M, Behar, Samuel M

“…Containment of Mycobacterium tuberculosis (Mtb) infection requires T cell recognition of infected macrophages. Mtb has evolved to tolerate, evade, and subvert…”
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Host genetic background is a barrier to broadly effective vaccine-mediated protection against tuberculosis by Lai, Rocky, Gong, Diana N, Williams, Travis, Ogunsola, Abiola F, Cavallo, Kelly, Lindestam Arlehamn, Cecilia S, Acolatse, Sarah, Beamer, Gillian L, Ferris, Martin T, Sassetti, Christopher M, Lauffenburger, Douglas A, Behar, Samuel M

“…Heterogeneity in human immune responses is difficult to model in standard laboratory mice. To understand how host variation affects Bacillus Calmette…”
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Key advances in vaccine development for tuberculosis—success and challenges by Lai, Rocky, Ogunsola, Abiola F., Rakib, Tasfia, Behar, Samuel M.

“…Breakthrough findings in the clinical and preclinical development of tuberculosis (TB) vaccines have galvanized the field and suggest, for the first time since…”
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Tim3 binding to galectin-9 stimulates antimicrobial immunity by Jayaraman, Pushpa, Sada-Ovalle, Isabel, Beladi, Sarah, Anderson, Ana C, Dardalhon, Valerie, Hotta, Chie, Kuchroo, Vijay K, Behar, Samuel M

“…T cell immunoglobulin and mucin domain 3 (Tim3) is a negative regulatory molecule that inhibits effector T(H)1-type responses. Such inhibitory signals prevent…”
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Innate invariant NKT cells recognize Mycobacterium tuberculosis-infected macrophages, produce interferon-gamma, and kill intracellular bacteria by Sada-Ovalle, Isabel, Chiba, Asako, Gonzales, Adaena, Brenner, Michael B, Behar, Samuel M

“…Cellular immunity to Mycobacterium tuberculosis (Mtb) requires a coordinated response between the innate and adaptive arms of the immune system, resulting in a…”
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Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype by Smith, Clare M, Proulx, Megan K, Olive, Andrew J, Laddy, Dominick, Mishra, Bibhuti B, Moss, Caitlin, Gutierrez, Nuria Martinez, Bellerose, Michelle M, Barreira-Silva, Palmira, Phuah, Jia Yao, Baker, Richard E, Behar, Samuel M, Kornfeld, Hardy, Evans, Thomas G, Beamer, Gillian, Sassetti, Christopher M

“…The outcome of Mycobacterium tuberculosis infection and the immunological response to the bacillus Calmette-Guerin (BCG) vaccine are highly variable in humans…”
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A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response by Sutiwisesak, Rujapak, Hicks, Nathan D, Boyce, Shayla, Murphy, Kenan C, Papavinasasundaram, Kadamba, Carpenter, Stephen M, Boucau, Julie, Joshi, Neelambari, Le Gall, Sylvie, Fortune, Sarah M, Sassetti, Christopher M, Behar, Samuel M

“…CD8 T cells provide limited protection against Mycobacterium tuberculosis (Mtb) infection in the mouse model. As Mtb causes chronic infection in mice and…”
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Tuberculosis Triggers a Tissue-Dependent Program of Differentiation and Acquisition of Effector Functions by Circulating Monocytes by Skold, Markus, Behar, Samuel M

“…The origin and function of the different myeloid cell subsets that appear in the lung during pulmonary tuberculosis are unknown. Herein we show that adoptively…”
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A Higher Activation Threshold of Memory CD8+ T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis by Carpenter, Stephen M, Nunes-Alves, Cláudio, Booty, Matthew G, Way, Sing Sing, Behar, Samuel M

“…T cell vaccines against Mycobacterium tuberculosis (Mtb) and other pathogens are based on the principle that memory T cells rapidly generate effector responses…”
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