Search Results - "Behan, Fiona M"

Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens by Behan, Fiona M., Iorio, Francesco, Picco, Gabriele, Gonçalves, Emanuel, Beaver, Charlotte M., Migliardi, Giorgia, Santos, Rita, Rao, Yanhua, Sassi, Francesco, Pinnelli, Marika, Ansari, Rizwan, Harper, Sarah, Jackson, David Adam, McRae, Rebecca, Pooley, Rachel, Wilkinson, Piers, van der Meer, Dieudonne, Dow, David, Buser-Doepner, Carolyn, Bertotti, Andrea, Trusolino, Livio, Stronach, Euan A., Saez-Rodriguez, Julio, Yusa, Kosuke, Garnett, Mathew J.

“…Functional genomics approaches can overcome limitations—such as the lack of identification of robust targets and poor clinical efficacy—that hamper cancer drug…”
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Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets by Dempster, Joshua M., Pacini, Clare, Pantel, Sasha, Behan, Fiona M., Green, Thomas, Krill-Burger, John, Beaver, Charlotte M., Younger, Scott T., Zhivich, Victor, Najgebauer, Hanna, Allen, Felicity, Gonçalves, Emanuel, Shepherd, Rebecca, Doench, John G., Yusa, Kosuke, Vazquez, Francisca, Parts, Leopold, Boehm, Jesse S., Golub, Todd R., Hahn, William C., Root, David E., Garnett, Mathew J., Tsherniak, Aviad, Iorio, Francesco

“…Genome-scale CRISPR-Cas9 viability screens performed in cancer cell lines provide a systematic approach to identify cancer dependencies and new therapeutic…”
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Project Score database: a resource for investigating cancer cell dependencies and prioritizing therapeutic targets by Dwane, Lisa, Behan, Fiona M, Gonçalves, Emanuel, Lightfoot, Howard, Yang, Wanjuan, van der Meer, Dieudonne, Shepherd, Rebecca, Pignatelli, Miguel, Iorio, Francesco, Garnett, Mathew J

“…Abstract CRISPR genetic screens in cancer cell models are a powerful tool to elucidate oncogenic mechanisms and to identify promising therapeutic targets. The…”
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Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening by Picco, Gabriele, Chen, Elisabeth D., Alonso, Luz Garcia, Behan, Fiona M., Gonçalves, Emanuel, Bignell, Graham, Matchan, Angela, Fu, Beiyuan, Banerjee, Ruby, Anderson, Elizabeth, Butler, Adam, Benes, Cyril H., McDermott, Ultan, Dow, David, Iorio, Francesco, Stronach, Euan, Yang, Fengtang, Yusa, Kosuke, Saez-Rodriguez, Julio, Garnett, Mathew J.

“…Many gene fusions are reported in tumours and for most their role remains unknown. As fusions are used for diagnostic and prognostic purposes, and are targets…”
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Minimal genome-wide human CRISPR-Cas9 library by Gonçalves, Emanuel, Thomas, Mark, Behan, Fiona M, Picco, Gabriele, Pacini, Clare, Allen, Felicity, Vinceti, Alessandro, Sharma, Mamta, Jackson, David A, Price, Stacey, Beaver, Charlotte M, Dovey, Oliver, Parry-Smith, David, Iorio, Francesco, Parts, Leopold, Yusa, Kosuke, Garnett, Mathew J

“…CRISPR guide RNA libraries have been iteratively improved to provide increasingly efficient reagents, although their large size is a barrier for many…”
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Drug mechanism‐of‐action discovery through the integration of pharmacological and CRISPR screens by Gonçalves, Emanuel, Segura‐Cabrera, Aldo, Pacini, Clare, Picco, Gabriele, Behan, Fiona M, Jaaks, Patricia, Coker, Elizabeth A, van der Meer, Donny, Barthorpe, Andrew, Lightfoot, Howard, Mironenko, Tatiana, Beck, Alexandra, Richardson, Laura, Yang, Wanjuan, Lleshi, Ermira, Hall, James, Tolley, Charlotte, Hall, Caitlin, Mali, Iman, Thomas, Frances, Morris, James, Leach, Andrew R, Lynch, James T, Sidders, Ben, Crafter, Claire, Iorio, Francesco, Fawell, Stephen, Garnett, Mathew J

“…Low success rates during drug development are due, in part, to the difficulty of defining drug mechanism‐of‐action and molecular markers of therapeutic…”
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Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting by Iorio, Francesco, Behan, Fiona M, Gonçalves, Emanuel, Bhosle, Shriram G, Chen, Elisabeth, Shepherd, Rebecca, Beaver, Charlotte, Ansari, Rizwan, Pooley, Rachel, Wilkinson, Piers, Harper, Sarah, Butler, Adam P, Stronach, Euan A, Saez-Rodriguez, Julio, Yusa, Kosuke, Garnett, Mathew J

“…Genome editing by CRISPR-Cas9 technology allows large-scale screening of gene essentiality in cancer. A confounding factor when interpreting CRISPR-Cas9…”
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Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects by Gonçalves, Emanuel, Behan, Fiona M, Louzada, Sandra, Arnol, Damien, Stronach, Euan A, Yang, Fengtang, Yusa, Kosuke, Stegle, Oliver, Iorio, Francesco, Garnett, Mathew J

“…CRISPR-Cas9 genome editing is widely used to study gene function, from basic biology to biomedical research. Structural rearrangements are a ubiquitous feature…”
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Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway by Chai, Annie Wai Yeeng, Yee, Pei San, Price, Stacey, Yee, Shi Mun, Lee, Hui Mei, Tiong, Vivian Kh, Gonçalves, Emanuel, Behan, Fiona M, Bateson, Jessica, Gilbert, James, Tan, Aik Choon, McDermott, Ultan, Garnett, Mathew J, Cheong, Sok Ching

“…New therapeutic targets for oral squamous cell carcinoma (OSCC) are urgently needed. We conducted genome-wide CRISPR-Cas9 screens in 21 OSCC cell lines,…”
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siRNA Library Screening Identifies a Druggable Immune-Signature Driving Esophageal Adenocarcinoma Cell Growth by Duggan, Shane P, Garry, Catherine, Behan, Fiona M, Phipps, Sinead, Kudo, Hiromi, Kirca, Murat, Zaheer, Abdul, McGarrigle, Sarah, Reynolds, John V, Goldin, Robert, Kalloger, Steve E, Schaeffer, David F, Long, Aideen, Strid, Jessica, Kelleher, Dermot

“…Background & Aims Effective therapeutic approaches are urgently required to tackle the alarmingly poor survival outcomes in esophageal adenocarcinoma (EAC)…”
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A comprehensive clinically informed map of dependencies in cancer cells and framework for target prioritization by Pacini, Clare, Duncan, Emma, Gonçalves, Emanuel, Gilbert, James, Bhosle, Shriram, Horswell, Stuart, Karakoc, Emre, Lightfoot, Howard, Curry, Ed, Muyas, Francesc, Bouaboula, Monsif, Pedamallu, Chandra Sekhar, Cortes-Ciriano, Isidro, Behan, Fiona M, Zalmas, Lykourgos-Panagiotis, Barthorpe, Andrew, Francies, Hayley, Rowley, Steve, Pollard, Jack, Beltrao, Pedro, Parts, Leopold, Iorio, Francesco, Garnett, Mathew J

“…Genetic screens in cancer cell lines inform gene function and drug discovery. More comprehensive screen datasets with multi-omics data are needed to enhance…”
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The characterization of an intestine-like genomic signature maintained during Barrett’s-associated adenocarcinogenesis reveals an NR5A2-mediated promotion of cancer cell survival by Duggan, Shane P., Behan, Fiona M., Kirca, Murat, Zaheer, Abdul, McGarrigle, Sarah A., Reynolds, John V., Vaz, Gisela M. F., Senge, Mathias O., Kelleher, Dermot

“…Barrett’s oesophagus (BO), an intestinal-type metaplasia (IM), typically arising in conjunction with gastro-oesophageal reflux disease, is a prominent risk…”
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Su1865 The Tumorigenic Potential of an Oesophageal Adenocarcinoma Cell Line is Increased Following Suppression of CDx2 Expression by Behan, Fiona M, Duggan, Shane P, Kelleher, Dermot P

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859 A Genomic Intestinal Signature of Barrett's Esophagus (BE) Defines Reflux Inducible Transcription Factors Proximally Encoded to BE and Adenocarcinoma Associated Genetic Loci by Duggan, Shane P, Kirca, Murat, Li, Xinzhong, Behan, Fiona M, McGarrigle, Sarah A, Jankowski, Janusz A, Kelleher, Dermot

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Su1174 Members of the Dual Specificity Protein Phosphatase Subfamily 1,5 and 6 are Influenced by Bile Acids and Over-Expressed in Barrett's Esophagus by Kirca, Murat, Duggan, Shane P, Behan, Fiona M, McEnroy, Deirdre, Zaheer, Abdul, Kelleher, Dermot P

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Down-Regulation of Rora Transcriptional Target, Aryl Hydrocarbon Receptor Nuclear Translocator-Like 2 (ARNTL2), in Barrett's Metaplasia, Implications for Circadian Rhythm by Duggan, Shane P, Kirca, Murat, Behan, Fiona M, Fallon, Padraic G, Kelleher, Dermot P

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Gdf15 is Over-Expressed in Barrett's Esophagus (BE), Induces SMAD Activation and May Play a Crucial Role in the Transcriptional Cascade Leading to Cell Differentiation and Transformation by Kirca, Murat, Duggan, Shane P, Behan, Fiona M, Zaheer, Abdul, Kelleher, Dermot P

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S1635 Loss of Bile Acid Responsive Gene Retinoic Acid Receptor-Related Orphan Receptor A (Rora) in Barrett's Metaplasia, Implications for Refluxed Induced Signaling in Esophageal Cells by Duggan, Shane P, Kirca, Murat, Behan, Fiona M, Kelleher, Dermot P

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S1055 SiRNA-Mediated Inhibitory G-Protein Coupled Receptor Library Screening Identifies Il8rα and CCL25 as Potential Modulators of Resistance to Deoxycholate Acid Mediated Cell Death in an Esophageal Cell Line by Behan, Fiona M, Duggan, Shane P, Abdel-Latif, Mohamed M, Kelleher, Dermot P

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Corrigendum: The characterization of an intestine-like genomic signature maintained during Barrett's-associated adenocarcinogenesis reveals an NR5A2-mediated promotion of cancer cell survival by Duggan, Shane P, Behan, Fiona M, Kirca, Murat, Zaheer, Abdul, McGarrigle, Sarah A, Reynolds, John V, Vaz, Gisela M F, Senge, Mathias O, Kelleher, Dermot

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