Search Results - "Begum, Afrin"

Experimental genital tract infection demonstrates Neisseria gonorrhoeae MtrCDE efflux pump is not required for in vivo human infection and identifies gonococcal colonization bottleneck by Waltmann, Andreea, Balthazar, Jacqueline T, Begum, Afrin A, Hua, Nancy, Jerse, Ann E, Shafer, William M, Hobbs, Marcia M, Duncan, Joseph A

“…The MtrCDE efflux pump of Neisseria gonorrhoeae exports a wide range of antimicrobial compounds that the gonococcus encounters at mucosal surfaces during…”
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The serogroup B meningococcal outer membrane vesicle-based vaccine 4CMenB induces cross-species protection against Neisseria gonorrhoeae by Leduc, Isabelle, Connolly, Kristie L, Begum, Afrin, Underwood, Knashka, Darnell, Stephen, Shafer, William M, Balthazar, Jacqueline T, Macintyre, Andrew N, Sempowski, Gregory D, Duncan, Joseph A, Little, Marguerite B, Rahman, Nazia, Garges, Eric C, Jerse, Ann E

“…There is a pressing need for a gonorrhea vaccine due to the high disease burden associated with gonococcal infections globally and the rapid evolution of…”
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Meningococcal Detoxified Outer Membrane Vesicle Vaccines Enhance Gonococcal Clearance in a Murine Infection Model by Matthias, Kathryn A, Connolly, Kristie L, Begum, Afrin A, Jerse, Ann E, Macintyre, Andrew N, Sempowski, Gregory D, Bash, Margaret C

“…Abstract Background Despite decades of research efforts, development of a gonorrhea vaccine has remained elusive. Epidemiological studies suggest that…”
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A Single Amino Acid Substitution in Elongation Factor G Can Confer Low-Level Gentamicin Resistance in Neisseria gonorrhoeae by Holley, Concerta L, Dhulipala, Vijaya, Balthazar, Jacqueline T, Le Van, Adriana, Begum, Afrin A, Chen, Shao-Chun, Read, Timothy D, Matoga, Mitch, Hoffman, Irving F, Golparian, Daniel, Unemo, Magnus, Jerse, Ann E, Shafer, William M

“…The continued emergence of Neisseria gonorrhoeae isolates which are resistant to first-line antibiotics has reinvigorated interest in alternative therapies…”
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cis - and trans -Acting Factors Influence Expression of the norM -Encoded Efflux Pump of Neisseria gonorrhoeae and Levels of Gonococcal Susceptibility to Substrate Antimicrobials by Rouquette-Loughlin, Corinne E, Dhulipala, Vijaya, Reimche, Jennifer L, Raterman, Erica, Begum, Afrin A, Jerse, Ann E, Shafer, William M

“…The gonococcal NorM efflux pump exports substrates with a cationic moiety, including quaternary ammonium compounds such as berberine (BE) and ethidium bromide…”
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Phosphoethanolamine decoration of Neisseria gonorrhoeae lipid A plays a dual immunostimulatory and protective role during experimental genital tract infection by Packiam, Mathanraj, Yedery, Roshan D, Begum, Afrin A, Carlson, Russell W, Ganguly, Jhuma, Sempowski, Gregory D, Ventevogel, Melissa S, Shafer, William M, Jerse, Ann E

“…The induction of an intense inflammatory response by Neisseria gonorrhoeae and the persistence of this pathogen in the presence of innate effectors is a…”
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Impact of Fluoroquinolone Resistance Mutations on Gonococcal Fitness and In Vivo Selection for Compensatory Mutations by Kunz, Anjali N., Begum, Afrin A., Wu, Hong, D'Ambrozio, Jonathan A., Robinson, James M., Shafer, William M., Bash, Margaret C., Jerse, Ann E.

“…Background. Quinolone-resistant Neisseria gonorrhoeae (QRNG) arise from mutations in gyrA (intermediate resistance) or gyrA and parC (resistance). Here we…”
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Estradiol-Treated Female Mice as Surrogate Hosts for Neisseria gonorrhoeae Genital Tract Infections by Jerse, Ann E, Wu, Hong, Packiam, Mathanraj, Vonck, Rachel A, Begum, Afrin A, Garvin, Lotisha E

“…Historically, animal modeling of gonorrhea has been hampered by the exclusive adaptation of Neisseria gonorrhoeae to humans. Genital tract infection can be…”
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Lipid A's structure mediates Neisseria gonorrhoeae fitness during experimental infection of mice and men by Hobbs, Marcia M, Anderson, James E, Balthazar, Jacqueline T, Kandler, Justin L, Carlson, Russell W, Ganguly, Jhuma, Begum, Afrin A, Duncan, Joseph A, Lin, Jessica T, Sparling, P Frederick, Jerse, Ann E, Shafer, William M

“…Phosphoethanolamine (PEA) on Neisseria gonorrhoeae lipid A influences gonococcal inflammatory signaling and susceptibility to innate host defenses in in vitro…”
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Control of gdhR Expression in Neisseria gonorrhoeae via Autoregulation and a Master Repressor (MtrR) of a Drug Efflux Pump Operon by Rouquette-Loughlin, Corinne E, Zalucki, Yaramah M, Dhulipala, Vijaya L, Balthazar, Jacqueline T, Doyle, Raúl G, Nicholas, Robert A, Begum, Afrin A, Raterman, Erica L, Jerse, Ann E, Shafer, William M

“…The MtrCDE efflux pump of contributes to gonococcal resistance to a number of antibiotics used previously or currently in treatment of gonorrhea, as well as to…”
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Hydrogen Peroxide–Producing Lactobacilli Inhibit Gonococci In Vitro but Not during Experimental Genital Tract Infection by Muench, Dawn F., Kuch, David J., Wu, Hong, Begum, Afrin A., Veit, Sandra J., Pelletier, Marie-Eve, Soler-García, Ángel A., Jerse, Ann E.

“…Commensal lactobacilli that produce hydrogen peroxide (H2O2) inhibit Neisseria gonorrhoeae in vitro, and clinical data suggest that they are associated with a…”
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H2O2-producing Lactobacilli Inhibit Gonococci in vitro But Not during Experimental Genital Tract Infection by Muench, Dawn F., Kuch, David J., Wu, Hong, Begum, Afrin A., Veit, Sandra J., Pelletier, Marie-Eve, Soler-García, Ángel A., Jerse, Ann E.

“…H 2 O 2 -producing commensal lactobacilli inhibit N. gonorrhoeae in vitro and clinical data suggest they are associated with reduced risk of gonorrhea. Here we…”
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Control of italic toggle="yes">gdhR /italic> Expression in italic toggle="yes">Neisseria gonorrhoeae /italic> via Autoregulation and a Master Repressor (MtrR) of a Drug Efflux Pump Operon by Corinne E. Rouquette-Loughlin, Yaramah M. Zalucki, Vijaya L. Dhulipala, Jacqueline T. Balthazar, Raúl G. Doyle, Robert A. Nicholas, Afrin A. Begum, Erica L. Raterman, Ann E. Jerse, William M. Shafer

“…ABSTRACT The MtrCDE efflux pump of Neisseria gonorrhoeae contributes to gonococcal resistance to a number of antibiotics used previously or currently in…”
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