Search Results - "Begovich, Ann"

A Large-Scale Genetic Association Study Confirms IL12B and Leads to the Identification of IL23R as Psoriasis-Risk Genes by Cargill, Michele, Schrodi, Steven J., Chang, Monica, Garcia, Veronica E., Brandon, Rhonda, Callis, Kristina P., Matsunami, Nori, Ardlie, Kristin G., Civello, Daniel, Catanese, Joseph J., Leong, Diane U., Panko, Jackie M., McAllister, Linda B., Hansen, Christopher B., Papenfuss, Jason, Prescott, Stephen M., White, Thomas J., Leppert, Mark F., Krueger, Gerald G., Begovich, Ann B.

“…We performed a multitiered, case-control association study of psoriasis in three independent sample sets of white North American individuals (1,446 cases and…”
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Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways by Gladman, Dafna, Begovich, Ann B, Liao, Wilson, Nair, Rajan P, Bowcock, Anne M, Ruether, Andreas, Voorhees, John J, Schrodi, Steven J, Rahman, Proton, Goldgar, David, Fischer, Judith, Weichenthal, Michael, Guthery, Stephen L, Menter, Alan, Gudjonsson, Johann E, Ding, Jun, Tejasvi, Trilokraj, Kwok, Pui-Yan, Elder, James T, Duffin, Kristina Callis, Li, Yun, Prahalad, Sampath, Abecasis, Gonçalo R, Schreiber, Stefan, Feng, Bing-Jian, Wise, Carol A, Lathrop, G Mark, Krueger, Gerald G, Stuart, Philip E, Helms, Cynthia

“…Psoriasis is a common immune-mediated disorder that affects the skin, nails and joints. To identify psoriasis susceptibility loci, we genotyped 438,670 SNPs in…”
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Unraveling the genetics of complex diseases: Susceptibility genes for rheumatoid arthritis and psoriasis by Li, Yonghong, Begovich, Ann B

“…Abstract Talk of numerous genetic risk factors for rheumatoid arthritis (RA) and psoriasis has been percolating for years, but with the exception of the human…”
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Multiple Loci within the major histocompatibility complex confer risk of psoriasis by Feng, Bing-Jian, Sun, Liang-Dan, Soltani-Arabshahi, Razieh, Bowcock, Anne M, Nair, Rajan P, Stuart, Philip, Elder, James T, Schrodi, Steven J, Begovich, Ann B, Abecasis, Gonçalo R, Zhang, Xue-Jun, Callis-Duffin, Kristina P, Krueger, Gerald G, Goldgar, David E

“…Psoriasis is a common inflammatory skin disease characterized by thickened scaly red plaques. Previously we have performed a genome-wide association study…”
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REL, encoding a member of the NF-[kappa]B family of transcription factors, is a newly defined risk locus for rheumatoid arthritis by Gregersen, Peter K, Amos, Chistopher I, Lee, Annette T, Lu, Yue, Remmers, Elaine F, Kastner, Daniel L, Seldin, Michael F, Criswell, Lindsey A, Plenge, Robert M, Holers, V Michael, Mikuls, Ted R, Sokka, Tuulikki, Moreland, Larry W, Bridges, S Louis, Xie, Gang, Begovich, Ann B, Siminovitch, Katherine A

“…We conducted a genome-wide association study of rheumatoid arthritis in 2,418 cases and 4,504 controls from North America and identified an association at the…”
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REL , encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis by Gregersen, Peter K, Siminovitch, Katherine A, Amos, Chistopher I, Lee, Annette T, Lu, Yue, Remmers, Elaine F, Kastner, Daniel L, Seldin, Michael F, Criswell, Lindsey A, Plenge, Robert M, Holers, V Michael, Mikuls, Ted R, Sokka, Tuulikki, Moreland, Larry W, Bridges, S Louis, Xie, Gang, Begovich, Ann B

“…Peter Gregersen and colleagues report that common variants at the REL locus are associated with risk of rheumatoid arthritis. REL encodes a member of the NF-κB…”
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PTPN22: Setting thresholds for autoimmunity by Gregersen, Peter K., Lee, Hye-Soon, Batliwalla, Franak, Begovich, Ann B.

“…The 620W allelic variant of the intracellular tyrosine phosphatase, PTPN22, is associated with a number of different autoimmune disorders, and this provides…”
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The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation by Shaw, Bronwen E., Gooley, Theodore A., Malkki, Mari, Madrigal, J. Alejandro, Begovich, Ann B., Horowitz, Mary M., Gratwohl, Alois, Ringdén, Olle, Marsh, Steven G.E., Petersdorf, Effie W.

“…Hematopoietic cell transplantation (HCT) from an HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 allele–matched unrelated donor is a well-recognized life-saving…”
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A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis by Kurreeman, Fina A S, Padyukov, Leonid, Marques, Rute B, Schrodi, Steven J, Seddighzadeh, Maria, Stoeken-Rijsbergen, Gerrie, van der Helm-van Mil, Annette H M, Allaart, Cornelia F, Verduyn, Willem, Houwing-Duistermaat, Jeanine, Alfredsson, Lars, Begovich, Ann B, Klareskog, Lars, Huizinga, Tom W J, Toes, Rene E M

“…Rheumatoid arthritis (RA) is a chronic autoimmune disorder affecting approximately 1% of the population. The disease results from the interplay between an…”
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A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase ( PTPN22) Is Associated with Rheumatoid Arthritis by Begovich, Ann B., Carlton, Victoria E.H., Honigberg, Lee A., Schrodi, Steven J., Chokkalingam, Anand P., Alexander, Heather C., Ardlie, Kristin G., Huang, Qiqing, Smith, Ashley M., Spoerke, Jill M., Conn, Marion T., Chang, Monica, Chang, Sheng-Yung P., Saiki, Randall K., Catanese, Joseph J., Leong, Diane U., Garcia, Veronica E., McAllister, Linda B., Jeffery, Douglas A., Lee, Annette T., Batliwalla, Franak, Remmers, Elaine, Criswell, Lindsey A., Seldin, Michael F., Kastner, Daniel L., Amos, Christopher I., Sninsky, John J., Gregersen, Peter K.

“…Rheumatoid arthritis (RA) is the most common systemic autoimmune disease, affecting ∼1% of the adult population worldwide, with an estimated heritability of…”
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Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis by Barcellos, Lisa F., Sawcer, Stephen, Ramsay, Patricia P., Baranzini, Sergio E., Thomson, Glenys, Briggs, Farren, Cree, Bruce C.A., Begovich, Ann B., Villoslada, Pablo, Montalban, Xavier, Uccelli, Antonio, Savettieri, Giovanni, Lincoln, Robin R., DeLoa, Carolyn, Haines, Jonathan L., Pericak-Vance, Margaret A., Compston, Alastair, Hauser, Stephen L., Oksenberg, Jorge R.

“…Variation in major histocompatibility complex genes on chromosome 6p21.3, specifically the human leukocyte antigen HLA-DR2 or DRB1*1501-DQB1*0602 extended…”
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Analysis of Families in the Multiple Autoimmune Disease Genetics Consortium (MADGC) Collection: the PTPN22 620W Allele Associates with Multiple Autoimmune Phenotypes by Criswell, Lindsey A., Pfeiffer, Kirsten A., Lum, Raymond F., Gonzales, Bonnie, Novitzke, Jill, Kern, Marlena, Moser, Kathy L., Begovich, Ann B., Carlton, Victoria E.H., Li, Wentian, Lee, Annette T., Ortmann, Ward, Behrens, Timothy W., Gregersen, Peter K.

“…Autoimmune disorders constitute a diverse group of phenotypes with overlapping features and a tendency toward familial aggregation. It is likely that common…”
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Carriers of Rare Missense Variants in IFIH1 Are Protected from Psoriasis by Li, Yonghong, Liao, Wilson, Cargill, Michele, Chang, Monica, Matsunami, Nori, Feng, Bing-Jian, Poon, Annie, Callis-Duffin, Kristina P., Catanese, Joseph J., Bowcock, Anne M., Leppert, Mark F., Kwok, Pui-Yan, Krueger, Gerald G., Begovich, Ann B.

“…Testing of ∼25,000 putative functional single-nucleotide polymorphisms (SNPs) across the human genome in a genetic association study has identified three…”
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Genetic Association of the R620W Polymorphism of Protein Tyrosine Phosphatase PTPN22 with Human SLE by Kyogoku, Chieko, Ortmann, Ward A., Lee, Annette, Selby, Scott, Carlton, Victoria E.H., Chang, Monica, Ramos, Paula, Baechler, Emily C., Batliwalla, Franak M., Novitzke, Jill, Williams, Adrienne H., Gillett, Clarence, Rodine, Peter, Graham, Robert R., Ardlie, Kristin G., Gaffney, Patrick M., Moser, Kathy L., Petri, Michelle, Begovich, Ann B., Gregersen, Peter K., Langefeld, Carl D., Behrens, Timothy W.

“…We genotyped 525 independent North American white individuals with systemic lupus erythematosus (SLE) for the PTPN22 R620W polymorphism and compared the…”
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Further Genetic Evidence for Three Psoriasis-Risk Genes: ADAM33, CDKAL1, and PTPN22 by Li, Yonghong, Liao, Wilson, Chang, Monica, Schrodi, Steven J., Bui, Nam, Catanese, Joseph J., Poon, Annie, Matsunami, Nori, Callis-Duffin, Kristina P., Leppert, Mark F., Bowcock, Anne M., Kwok, Pui-Yan, Krueger, Gerald G., Begovich, Ann B.

“…Predisposition to psoriasis is known to be affected by genetic variation in HLA-C, IL12B, and IL23R, and although other psoriasis-associated variants have been…”
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PTPN22 Genetic Variation: Evidence for Multiple Variants Associated with Rheumatoid Arthritis by Carlton, Victoria E.H., Hu, Xiaolan, Chokkalingam, Anand P., Schrodi, Steven J., Brandon, Rhonda, Alexander, Heather C., Chang, Monica, Catanese, Joseph J., Leong, Diane U., Ardlie, Kristin G., Kastner, Daniel L., Seldin, Michael F., Criswell, Lindsey A., Gregersen, Peter K., Beasley, Ellen, Thomson, Glenys, Amos, Christopher I., Begovich, Ann B.

“…The minor allele of the R620W missense single-nucleotide polymorphism (SNP) ( rs2476601) in the hematopoietic-specific protein tyrosine phosphatase gene,…”
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A combined DPA1∼DPB1 amino acid epitope is the primary unit of selection on the HLA-DP heterodimer by Hollenbach, Jill A., Madbouly, Abeer, Gragert, Loren, Vierra-Green, Cynthia, Flesch, Susan, Spellman, Stephen, Begovich, Ann, Noreen, Harriet, Trachtenberg, Elizabeth, Williams, Tom, Yu, Neng, Shaw, Bronwen, Fleischhauer, Katharina, Fernandez-Vina, Marcelo, Maiers, Martin

“…Here, we present results for DPA1 and DPB1 four-digit allele-level typing in a large ( n  = 5,944) sample of unrelated European American stem cell donors…”
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Correlation analyses of clinical and molecular findings identify candidate biological pathways in systemic juvenile idiopathic arthritis by Ling, Xuefeng B, Macaubas, Claudia, Alexander, Heather C, Wen, Qiaojun, Chen, Edward, Peng, Sihua, Sun, Yue, Deshpande, Chetan, Pan, Kuang-Hung, Lin, Richard, Lih, Chih-Jian, Chang, Sheng-Yung P, Lee, Tzielan, Sandborg, Christy, Begovich, Ann B, Cohen, Stanley N, Mellins, Elizabeth D

“…Clinicians have long appreciated the distinct phenotype of systemic juvenile idiopathic arthritis (SJIA) compared to polyarticular juvenile idiopathic…”
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Alternative activation in systemic juvenile idiopathic arthritis monocytes by Macaubas, Claudia, Nguyen, Khoa D, Peck, Ariana, Buckingham, Julia, Deshpande, Chetan, Wong, Elizabeth, Alexander, Heather C, Chang, Sheng-Yung, Begovich, Ann, Sun, Yue, Park, Jane L, Pan, Kuang-Hung, Lin, Richard, Lih, Chih-Jian, Augustine, Erin M, Phillips, Carolyn, Hadjinicolaou, Andreas V, Lee, Tzielan, Mellins, Elizabeth D

“…Abstract Systemic juvenile idiopathic arthritis (SJIA) is a chronic autoinflammatory condition. The association with macrophage activation syndrome, and the…”
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A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2 by Chang, Monica, Rowland, Charles M, Garcia, Veronica E, Schrodi, Steven J, Catanese, Joseph J, van der Helm-van Mil, Annette H M, Ardlie, Kristin G, Amos, Christopher I, Criswell, Lindsey A, Kastner, Daniel L, Gregersen, Peter K, Kurreeman, Fina A S, Toes, Rene E M, Huizinga, Tom W J, Seldin, Michael F, Begovich, Ann B

“…Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease affecting both joints and extra-articular tissues. Although some genetic risk factors for…”
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