Search Results - "Begley, Lesa A"

ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer by Drosos, Yiannis, Escobar, David, Chiang, Ming-Yi, Roys, Kathryn, Valentine, Virginia, Valentine, Marc B., Rehg, Jerold E., Sahai, Vaibhav, Begley, Lesa A., Ye, Jianming, Paul, Leena, McKinnon, Peter J., Sosa-Pineda, Beatriz

“…Germline mutations in ATM (encoding the DNA-damage signaling kinase, ataxia-telangiectasia-mutated) increase Familial Pancreatic Cancer (FPC) susceptibility,…”
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Real Time Breath Analysis Using Portable Gas Chromatography for Adult Asthma Phenotypes by Sharma, Ruchi, Zang, Wenzhe, Zhou, Menglian, Schafer, Nicole, Begley, Lesa A, Huang, Yvonne J, Fan, Xudong

“…Asthma is heterogeneous but accessible biomarkers to distinguish relevant phenotypes remain lacking, particularly in non-Type 2 (T2)-high asthma. Moreover,…”
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CXCL5 Promotes Prostate Cancer Progression by Begley, Lesa A, Kasina, Sathish, Mehra, Rohit, Adsule, Shreelekha, Admon, Andrew J, Lonigro, Robert J, Chinnaiyan, Arul M, Macoska, Jill A

“…CXCL5 is a proangiogenic CXC-type chemokine that is an inflammatory mediator and a powerful attractant for granulocytic immune cells. Unlike many other…”
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Effects of Fluticasone Propionate on Klebsiella pneumoniae and Gram-Negative Bacteria Associated with Chronic Airway Disease by Begley, Lesa A, Opron, Kristopher, Bian, Guowu, Kozik, Ariangela J, Liu, Cai, Felton, Jeremy, Wen, Bo, Sun, Duxin, Huang, Yvonne J

“…Inhaled corticosteroids (ICS) are commonly prescribed first-line treatments for asthma and chronic obstructive pulmonary disease (COPD). Recent evidence has…”
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CXCL12 Activates a Robust Transcriptional Response in Human Prostate Epithelial Cells by Begley, Lesa A., MacDonald, James W., Day, Mark L., Macoska, Jill A.

“…CXCL12 is a CXC-type chemokine that plays important roles in hematopoiesis, development, and organization of the immune system and supports the survival or…”
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Airway microbiota and immune mediator relationships differ in obesity and asthma by Kozik, Ariangela J., Begley, Lesa A., Lugogo, Njira, Baptist, Alan, Erb-Downward, John, Opron, Kristopher, Huang, Yvonne J.

“…Asthma and obesity are both complex conditions characterized by chronic inflammation, and obesity-related severe asthma has been associated with differences in…”
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Lung Microbiota and Metabolites Collectively Associate with Clinical Outcomes in Milder Stage Chronic Obstructive Pulmonary Disease by Madapoosi, Siddharth S, Cruickshank-Quinn, Charmion, Opron, Kristopher, Erb-Downward, John R, Begley, Lesa A, Li, Gen, Barjaktarevic, Igor, Barr, R Graham, Comellas, Alejandro P, Couper, David J, Cooper, Christopher B, Freeman, Christine M, Han, MeiLan K, Kaner, Robert J, Labaki, Wassim, Martinez, Fernando J, Ortega, Victor E, Peters, Stephen P, Paine, Robert, Woodruff, Prescott, Curtis, Jeffrey L, Huffnagle, Gary B, Stringer, Kathleen A, Bowler, Russell P, Esther, Jr, Charles R, Reisdorph, Nichole, Huang, Yvonne J

“…Chronic obstructive pulmonary disease (COPD) is variable in its development. Lung microbiota and metabolites collectively may impact COPD pathophysiology, but…”
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Loss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in Chronic Obstructive Pulmonary Disease by Opron, Kristopher, Begley, Lesa A, Erb-Downward, John R, Li, Gen, Alexis, Neil E, Barjaktarevic, Igor, Barr, R Graham, Bleecker, Eugene R, Boucher, Richard, Bowler, Russell P, Christenson, Stephanie A, Comellas, Alejandro P, Criner, Gerard, Cooper, Christopher B, Couper, David, Galban, Craig J, Han, MeiLan K, Hastie, Annette, Hatt, Charles, Hoffman, Eric A, Kaner, Robert J, Kesimer, Mehmet, Krishnan, Jerry A, LaFon, David C, Martinez, Fernando J, Ortega, Victor E, Peters, Stephen P, Paine, 3rd, Robert, Putcha, Nirupama, Woodruff, Prescott G, Huffnagle, Gary B, Kozik, Ariangela J, Curtis, Jeffrey L, Huang, Yvonne J

“…The airway microbiome has the potential to shape chronic obstructive pulmonary disease (COPD) pathogenesis, but its relationship to outcomes in milder disease…”
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Leukocytic promotion of prostate cellular proliferation by McDowell, Kristy L., Begley, Lesa A., Mor-Vaknin, Nirit, Markovitz, David M., Macoska, Jill A.

“…BACKGROUND Histological evidence of pervasive inflammatory infiltrate has been noted in both benign prostatic hyperplasia/hypertrophy (BPH) and prostate cancer…”
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Signaling mechanisms coupled to CXCL12/CXCR4-mediated cellular proliferation are PTEN-dependent by Begley, Lesa A, Kasina, Sathish, Shah, Rajal B, Macoska, Jill A

“…A key difference between normal and malignant prostate cells in vitro and in vivo is that both alleles of PTEN are largely intact in normal benign prostate…”
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Pilot and feasibility study of serum chemokines as markers to distinguish prostatic disease in men with low total serum PSA by Macoska, Jill A., Begley, Lesa A., Dunn, Rodney L., Siddiqui, Javed, Wei, John T., Sarma, Aruna V.

“…BACKGROUND The incidence and prevalence of both benign prostatic hypertrophy (BPH) and prostate cancer (PCa) increase with the aging process. Our laboratory…”
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Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort by Opron, Kristopher, Begley, Lesa A., Erb-Downward, John R., Freeman, Christine, Madapoosi, Siddharth, Alexis, Neil E., Barjaktarevic, Igor, Graham Barr, R., Bleecker, Eugene R., Bowler, Russell P., Christenson, Stephanie A., Comellas, Alejandro P., Cooper, Christopher B., Couper, David J., Doerschuk, Claire M., Dransfield, Mark T., Han, MeiLan K., Hansel, Nadia N., Hastie, Annette T., Hoffman, Eric A., Kaner, Robert J., Krishnan, Jerry, O’Neal, Wanda K., Ortega, Victor E., Paine, Robert, Peters, Stephen P., Michael Wells, J., Woodruff, Prescott G., Martinez, Fernando J., Curtis, Jeffrey L., Huffnagle, Gary B., Huang, Yvonne J.

“…Chronic obstructive pulmonary disease (COPD) is heterogeneous in development, progression, and phenotypes. Little is known about the lung microbiome, sampled…”
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CXCL5 Promotes Prostate Cancer Progression1 by Begley, Lesa A, Kasina, Sathish, Mehra, Rohit, Adsule, Shreelekha, Admon, Andrew J, Lonigro, Robert J, Chinnaiyan, Arul M, Macoska, Jill A

“…CXCL5 is a proangiogenic CXC-type chemokine that is an inflammatory mediator and a powerful attractant for granulocytic immune cells. Unlike many other…”
Get full text