Search Results - "Begley, CG"

Anti-Epo receptor antibodies do not predict Epo receptor expression by Elliott, Steve, Busse, Leigh, Bass, Michael B., Lu, Hsieng, Sarosi, Ildiko, Sinclair, Angus M., Spahr, Chris, Um, Moonkyoung, Van, Gwyneth, Begley, C. Glenn

“…Investigators using anti-EpoR antibodies for immunoblotting and immunostaining have reported erythropoietin receptor (EpoR) expression in nonhematopoietic…”
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Recombinant human thrombopoietin: basic biology and evaluation of clinical studies by Kuter, David J., Begley, C. Glenn

“…Thrombocytopenia is a common medical problem for which the main treatment is platelet transfusion. Given the increasing use of platelets and the declining…”
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The Relationship between Habitual Patient-Reported Symptoms and Clinical Signs among Patients with Dry Eye of Varying Severity by Begley, Carolyn G, Chalmers, Robin L, Abetz, Linda, Venkataraman, Kitty, Mertzanis, Polyxane, Caffery, Barbara A, Snyder, Christopher, Edrington, Timothy, Nelson, Daniel, Simpson, Trefford

“…To investigate symptom profiles and clinical signs in subjects with dry eye and normal subjects in a cross-sectional multicenter study. Subjects aged 35 to 65…”
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The Antibody Society's antibody validation webinar series by Voskuil, Jan L.A., Bandrowski, Anita, Begley, C. Glenn, Bradbury, Andrew R.M., Chalmers, Andrew D., Gomes, Aldrin V., Hardcastle, Travis, Lund-Johansen, Fridtjof, Plückthun, Andreas, Roncador, Giovanna, Solache, Alejandra, Taussig, Michael J., Trimmer, James S., Williams, Cecilia, Goodman, Simon L.

“…In the wake of the reproducibility crisis and numerous discussions on how commercially available antibodies as research tool contribute to it, The Antibody…”
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Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium by Göthert, Joachim R., Gustin, Sonja E., van Eekelen, J. Anke M., Schmidt, Uli, Hall, Mark A., Jane, Stephen M., Green, Anthony R., Göttgens, Berthold, Izon, David J., Begley, C. Glenn

“…Tumor growth is dependent in part on “neoangiogenesis.” Functional involvement of bone marrow (BM)-derived cells in this process has been demonstrated…”
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Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor by Basser, Russell L., O'Flaherty, Elizabeth, Green, Michael, Edmonds, Maria, Nichol, Janet, Menchaca, Dora M., Cohen, Brian, Begley, C. Glenn

“…Clinical trials of thrombopoietin (TPO), the central regulator of megakaryocytopoiesis, have revealed few side effects associated with its use. We here report…”
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The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S 12 by Hall, Mark A., Curtis, David J., Metcalf, Donald, Elefanty, Andrew G., Sourris, K., Robb, Lorraine, Göthert, Joachim R., Jane, Stephen M., Begley, C. Glenn

“…Gene targeting studies have shown that the transcription factor SCL is critically important for embryonic hematopoiesis, but the early lethality of SCL null…”
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In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis by Göthert, Joachim R., Gustin, Sonja E., Hall, Mark A., Green, Anthony R., Göttgens, Berthold, Izon, David J., Begley, C.Glenn

“…Evidence for the lineage relationship between embryonic and adult hematopoietic stem cells (HSCs) in the mouse is primarily indirect. In order to study this…”
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Use of the Dry Eye Questionnaire to Measure Symptoms of Ocular Irritation in Patients With Aqueous Tear Deficient Dry Eye by Begley, Carolyn G, Caffery, Barbara, Chalmers, Robin L, Mitchell, G Lynn

“…PURPOSE.To demonstrate the ability of the Dry Eye Questionnaire (DEQ) to characterize the frequency of ocular surface symptoms and their diurnal intensity in…”
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Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation by Robb, Lorraine, Li, Ruili, Hartley, Lynne, Nandurkar, Harshal H, Koentgen, Frank, Begley, C. Glenn

“…During early pregnancy, in response to the implanting embryo, the surrounding uterine stroma undergoes a dramatic transformation into a specialized tissue…”
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The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1 by LECUYER, Eric, HERBLOT, Sabine, SAINT-DENIS, Marianne, MARTIN, Richard, BEGLEY, C. Glenn, PORCHER, Catherine, ORKIN, Stuart H, HOANG, Trang

“…The combinatorial interaction among transcription factors is believed to determine hematopoietic cell fate. Stem cell leukemia (SCL, also known as TAL1 [T-cell…”
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The SCL Gene: From Case Report to Critical Hematopoietic Regulator by Begley, C. Glenn, Green, Anthony R.

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Characterization of Ocular Surface Symptoms From Optometric Practices in North America by Begley, Carolyn G, Chalmers, Robin L, Mitchell, G Lynn, Nichols, Kelly K, Caffery, Barbara, Simpson, Trefford, DuToit, Renee, Portello, Joan, Davis, Larry

“…PURPOSE.This study characterized ocular symptoms typical of dry eye in an unselected optometric clinical population in the United States and Canada…”
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Lineage-Restricted Regulation of the Murine SCL/TAL-1 Promoter by Bockamp, E.-O., McLaughlin, F., Murrell, A.M., Gottgens, B., Robb, L, Begley, C.G., Green, A.R.

“…The SCL/TAL-1 gene encodes a basic helix-loop-helix transcription factor that is expressed in multipotent hematopoietic progenitors before lineage commitment…”
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Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch by Guthridge, Mark A, Powell, Jason A, Barry, Emma F, Stomski, Frank C, McClure, Barbara J, Ramshaw, Hayley, Felquer, Fernando A, Dottore, Mara, Thomas, Daniel T, To, Bik, Begley, C Glenn, Lopez, Angel F

“…Pleiotropism is a hallmark of cytokines and growth factors; yet, the underlying mechanisms are not clearly understood. We have identified a motif in the…”
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Functional inactivation in mice of the gene for the interleukin-3 (IL-3)-specific receptor β-chain : Implications for IL-3 function and the mechanism of receptor transmodulation in hematopoietic cells by NICOLA, N. A, ROBB, L, METCALF, D, CARY, D, DRINKWATER, C. C, BEGLEY, C. G

“…The receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 and -5 (IL-3, IL-5) share a common signaling subunit (beta c)…”
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Bivalent IAP antagonists, but not monovalent IAP antagonists, inhibit TNF-mediated NF-[kappa]B signaling by degrading TRAF2-associated cIAP1 in cancer cells by Mitsuuchi, Y, Benetatos, Ca, Deng, Y, Haimowitz, T, Beck, Sc, Arnone, Mr, Kapoor, Gs, Seipel, Me, Chunduru, Sk, Mckinlay, Ma, Begley, Cg, Condon, Sm

“…The inhibitor of apoptosis (IAP) proteins have pivotal roles in cell proliferation and differentiation, and antagonizing IAPs in certain cancer cell lines…”
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Tear Breakup Dynamics: A Technique for Quantifying Tear Film Instability by BEGLEY, CAROLYN G, HIMEBAUGH, NIKOLE, RENNER, DEBRA, LIU, HAIXIA, CHALMERS, ROBIN, SIMPSON, TREFFORD, VARIKOOTY, JALAIAH

“…PURPOSE.The purpose of this study was to develop a novel, quantitative measurement of tear film breakup dynamics (TBUD) to study the phenomenon of tear breakup…”
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Differential Regulation of Macrophage Differentiation in Response to Leukemia Inhibitory Factor/Oncostatin-M/Interleukin-6: The Effect of Enforced Expression of the SCL Transcription Factor by Tanigawa, T., Nicola, N., McArthur, G.A., Strasser, A., Begley, C.G.

“…The physiologic program of macrophage differentiation normally proceeds in a coordinated manner in response to several different growth factors. Although the…”
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Effects of Purified Bacterially Synthesized Murine Multi-CSF (IL-3) on Hematopoiesis in Normal Adult Mice by Metcalf, D., Begley, C.G., Johnson, G.R., Nicola, N.A., Lopez, A.F., Williamson, D.J.

“…Normal adult C57BL, BALB/c, and C3H/HeJ mice were injected intraperitoneally three times daily for up to 6 days with 102,000 U (200 ng) per injection of…”
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