Fasting glucagon-like peptide 1 concentration is associated with lower carbohydrate intake and increases with overeating
Purpose Glucagon-like peptide 1 (GLP-1) is an incretin hormone that appears to play a major role in the control of food intake. The aim of this investigation was to evaluate and quantify the association of circulating GLP-1 concentration with ad libitum total calorie and macronutrient intake. Method...
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| Published in: | Journal of endocrinological investigation Vol. 42; no. 5; pp. 557 - 566 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Cham
Springer International Publishing
01-05-2019
Springer Nature B.V |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Purpose
Glucagon-like peptide 1 (GLP-1) is an incretin hormone that appears to play a major role in the control of food intake. The aim of this investigation was to evaluate and quantify the association of circulating GLP-1 concentration with ad libitum total calorie and macronutrient intake.
Methods
One-hundred and fifteen individuals (72 men) aged 35 ± 10 years were admitted for an inpatient study investigating the determinants of energy intake. Ad libitum food intake was assessed during 3 days using a reproducible vending machine paradigm. Fasting plasma GLP-1 concentrations were measured on the morning of the first day and on the morning of the fourth day after ad libitum feeding.
Results
Plasma GLP-1 concentrations increased by 14% after 3 days of ad libitum food intake. Individuals overate on average 139 ± 45% of weight-maintaining energy needs. Fasting plasma GLP-1 on day 1 was negatively associated with carbohydrate intake (
r
= − 0.2,
p
= 0.03) and with daily energy intake from low fat–high simple sugar (
r
= − 0.22,
p
= 0.016).
Conclusion
Higher plasma GLP-1 concentrations prior to ad libitum food intake were associated with lower carbohydrate intake and lower simple sugar ingestion, indicating a possible role of the GLP-1 in the reward pathway regulating simple sugar intake.
Trial registration
ClinicalTrials.gov identifier: NCT00342732. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Authors’last names: Basolo, Heinitz, Stinson, Begaye, Hohenadel, Piaggi, Krakoff, Votruba A.B. analyzed and interpreted data and wrote the manuscript. P.P. and E.S. assisted with the interpretation of the data and revised the manuscript. M.H. and S.H. supported with the interpretation of the data and reviewed the manuscript. S.V. and J.K. designed, implemented and conducted the study. All authors read and approved the final manuscript. All authors critically revised the draft and approved the final manuscript. A.B. had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis Author contributions |
| ISSN: | 1720-8386 0391-4097 1720-8386 |
| DOI: | 10.1007/s40618-018-0954-5 |