Search Results - "Beeson, Gyda C"

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma by Qie, Shuo, Yoshida, Akihiro, Parnham, Stuart, Oleinik, Natalia, Beeson, Gyda C., Beeson, Craig C., Ogretmen, Besim, Bass, Adam J., Wong, Kwok-Kin, Rustgi, Anil K., Diehl, J. Alan

“…The dysregulation of Fbxo4-cyclin D1 axis occurs at high frequency in esophageal squamous cell carcinoma (ESCC), where it promotes ESCC development and…”
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A high-throughput respirometric assay for mitochondrial biogenesis and toxicity by Beeson, Craig C., Beeson, Gyda C., Schnellmann, Rick G.

“…Mitochondria are a common target of toxicity for drugs and other chemicals and result in decreased aerobic metabolism and cell death. In contrast,…”
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Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity by Chakraborty, Paramita, Vaena, Silvia G., Thyagarajan, Krishnamurthy, Chatterjee, Shilpak, Al-Khami, Amir, Selvam, Shanmugam Panneer, Nguyen, Hung, Kang, Inhong, Wyatt, Megan W., Baliga, Uday, Hedley, Zachariah, Ngang, Rose N., Guo, Beichu, Beeson, Gyda C., Husain, Shahid, Paulos, Chrystal M., Beeson, Craig C., Zilliox, Michael J., Hill, Elizabeth G., Mehrotra, Meenal, Yu, Xue-Zhong, Ogretmen, Besim, Mehrotra, Shikhar

“…Sphingosine 1-phosphate (S1P), a bioactive lysophospholipid generated by sphingosine kinase 1 (SphK1), regulates lymphocyte egress into circulation via S1P…”
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The β2-adrenoceptor agonist formoterol stimulates mitochondrial biogenesis by Wills, Lauren P, Trager, Richard E, Beeson, Gyda C, Lindsey, Christopher C, Peterson, Yuri K, Beeson, Craig C, Schnellmann, Rick G

“…Mitochondrial dysfunction is a common mediator of disease and organ injury. Although recent studies show that inducing mitochondrial biogenesis (MB) stimulates…”
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A Screen Using iPSC-Derived Hepatocytes Reveals NAD+ as a Potential Treatment for mtDNA Depletion Syndrome by Jing, Ran, Corbett, James L., Cai, Jun, Beeson, Gyda C., Beeson, Craig C., Chan, Sherine S., Dimmock, David P., Lazcares, Lynn, Geurts, Aron M., Lemasters, John J., Duncan, Stephen A.

“…Patients with mtDNA depletion syndrome 3 (MTDPS3) often die as children from liver failure caused by severe reduction in mtDNA content. The identification of…”
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Systematic Study of Mitochondrial Toxicity of Environmental Chemicals Using Quantitative High Throughput Screening by Attene-Ramos, Matias S, Huang, Ruili, Sakamuru, Srilatha, Witt, Kristine L, Beeson, Gyda C, Shou, Louie, Schnellmann, Rick G, Beeson, Craig C, Tice, Raymond R, Austin, Christopher P, Xia, Menghang

“…A goal of the Tox21 program is to transit toxicity testing from traditional in vivo models to in vitro assays that assess how chemicals affect cellular…”
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Assessment of drug-induced mitochondrial dysfunction via altered cellular respiration and acidification measured in a 96-well platform by Nadanaciva, Sashi, Rana, Payal, Beeson, Gyda C., Chen, Denise, Ferrick, David A., Beeson, Craig C., Will, Yvonne

“…High-throughput applicable screens for identifying drug-induced mitochondrial impairment are necessary in the pharmaceutical industry. Hence, we evaluated the…”
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Repurposing Kir6/SUR2 Channel Activator Minoxidil to Arrests Growth of Gynecologic Cancers by Fukushiro-Lopes, Daniela, Hegel, Alexandra D, Russo, Angela, Senyuk, Vitalyi, Liotta, Margaret, Beeson, Gyda C, Beeson, Craig C, Burdette, Joanna, Potkul, Ronald K, Gentile, Saverio

“…Gynecologic cancers are among the most lethal cancers found in women, and, advanced stage cancers are still a treatment challenge. Ion channels are known to…”
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Renal Glomerular Mitochondria Function in Salt-Sensitive Hypertension by Domondon, Mark, Polina, Iuliia, Nikiforova, Anna B, Sultanova, Regina F, Kruger, Claudia, Vasileva, Valeriia Y, Fomin, Mikhail V, Beeson, Gyda C, Nieminen, Anna-Liisa, Smythe, Nancy, Maldonado, Eduardo N, Stadler, Krisztian, Ilatovskaya, Daria V

“…Salt-sensitive (SS) hypertension is accompanied with an early onset of proteinuria, which results from the loss of glomerular podocytes. Here, we hypothesized…”
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Flavin Adenine Dinucleotide Depletion Caused by electron transfer flavoprotein subunit alpha Haploinsufficiency Leads to Hepatic Steatosis and Injury in Zebrafish by Park, Ki‐Hoon, Gooz, Monika, Ye, Zhi‐Wei, Zhang, Jie, Beeson, Gyda C., Rockey, Don C., Kim, Seok‐Hyung

“…The electron transfer flavoprotein (ETF) complex, made up of the ETF alpha subunit (ETFA), ETF beta subunit (ETFB), and ETF dehydrogenase (ETFDH), regulates…”
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Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity by Richards, Dylan J., Li, Yang, Kerr, Charles M., Yao, Jenny, Beeson, Gyda C., Coyle, Robert C., Chen, Xun, Jia, Jia, Damon, Brooke, Wilson, Robert, Starr Hazard, E., Hardiman, Gary, Menick, Donald R., Beeson, Craig C., Yao, Hai, Ye, Tong, Mei, Ying

“…Environmental factors are the largest contributors to cardiovascular disease. Here we show that cardiac organoids that incorporate an oxygen-diffusion gradient…”
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A new fluorescent sensor mitoferrofluor indicates the presence of chelatable iron in polarized and depolarized mitochondria by Kholmukhamedov, Andaleb, Li, Li, Lindsey, Christopher C., Hu, Jiangting, Nieminen, Anna-Liisa, Takemoto, Kenji, Beeson, Gyda C., Beneker, Chad M., McInnes, Campbell, Beeson, Craig C., Lemasters, John J.

“…Mitochondrial chelatable iron contributes to the severity of several injury processes, including ischemia/reperfusion, oxidative stress, and drug toxicity…”
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Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function by Chakraborty, Paramita, Parikh, Rasesh Y, Choi, Seungho, Tran, Danh, Gooz, Monika, Hedley, Zachariah T, Kim, Do-Sung, Pytel, Dariusz, Kang, Inhong, Nadig, Satish N, Beeson, Gyda C, Ball, Lauren, Mehrotra, Meenal, Wang, Hongjun, Berto, Stefano, Palanisamy, Viswanathan, Li, Hong, Chatterjee, Shilpak, Rodriguez, Paulo C, Maldonado, Eduardo N, Diehl, J Alan, Gangaraju, Vamsi K, Mehrotra, Shikhar

“…Mitochondria and endoplasmic reticulum (ER) share structural and functional networks and activate well-orchestrated signaling processes to shape cells' fate…”
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Statin‐dependent modulation of mitochondrial metabolism in cancer cells is independent of cholesterol content by Christie, Charleston F., Fang, Diana, Hunt, Elizabeth G., Morris, Morgan E., Rovini, Amandine, Heslop, Kareem A., Beeson, Gyda C., Beeson, Craig C., Maldonado, Eduardo N.

“…ABSTRACT Statins, widely used to treat hypercholesterolemia, inhibit the 3‐hydroxy‐3‐methylglutary1‐coenzyme A reductase, the rate‐limiting enzyme of de novo…”
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Activation of Wnt/β‐catenin signalling and HIF1α stabilisation alters pluripotency and differentiation/proliferation properties of human‐induced pluripotent stem cells by Wei, Hua, Beeson, Gyda C., Ye, Zhiwei, Zhang, Jie, Yao, Hai, Damon, Brooke, Morad, Martin

“…Background Information Wnt/β‐catenin signalling, in the microenvironment of pluripotent stem cells (PSCs), plays a critical role in their differentiation and…”
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PDE5 inhibition rescues mitochondrial dysfunction and angiogenic responses induced by Akt3 inhibition by promotion of PRC expression by Corum, Daniel G., Jenkins, Dorea P., Heslop, James A., Tallent, Lacey M., Beeson, Gyda C., Barth, Jeremy L., Schnellmann, Rick G., Muise-Helmericks, Robin C.

“…Akt3 regulates mitochondrial content in endothelial cells through the inhibition of PGC-1α nuclear localization and is also required for angiogenesis. However,…”
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Assessment of ToxCast Phase II for Mitochondrial Liabilities Using a High-Throughput Respirometric Assay by Wills, Lauren P, Beeson, Gyda C, Hoover, Douglas B, Schnellmann, Rick G, Beeson, Craig C

“…Previous high-throughput screens to identify mitochondrial toxicants used immortalized cell lines and focused on changes in mitochondrial membrane potential,…”
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Estrogen-Related Receptor α (ERRα) is required for adaptive increases in PGC-1 isoform expression during electrically stimulated contraction of adult cardiomyocytes in sustained hypoxic conditions by Cunningham, Kathryn F, Beeson, Gyda C, Beeson, Craig C, Baicu, Catalin F, Zile, Michael R, McDermott, Paul J

“…Abstract Background and objectives In adult myocardium, Estrogen-Related Receptor α (ERRα) programs energetic capacity of cardiomyocytes by regulating…”
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High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury by Wills, Lauren P., Beeson, Gyda C., Trager, Richard E., Lindsey, Christopher C., Beeson, Craig C., Peterson, Yuri K., Schnellmann, Rick G.

“…Many environmental chemicals and drugs negatively affect human health through deleterious effects on mitochondrial function. Currently there is no chemical…”
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Integrin-dependent Akt1 activation regulates PGC-1 expression and fatty acid oxidation by Beeson, Craig C, Beeson, Gyda C, Buff, Haley, Eldridge, Juanita, Zhang, Aiguo, Seth, Arun, Demcheva, Marina, Vournakis, John N, Muise-Helmericks, Robin C

“…Poly-N-acetyl glucosamine nanofibers derived from a marine diatom have been used to increase cutaneous wound healing. These nanofibers exert their activity by…”
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