Search Results - "Beesley, Philip"

Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2 by Russell, Claire L, Semerdjieva, Sophia, Empson, Ruth M, Austen, Brian M, Beesley, Philip W, Alifragis, Pavlos

“…It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of dementia in Alzheimer's disease (AD) are associated with…”
Get full text

The Neuroplastin adhesion molecules: key regulators of neuronal plasticity and synaptic function by Beesley, Philip W., Herrera‐Molina, Rodrigo, Smalla, Karl‐Heinz, Seidenbecher, Constanze

“…The Neuroplastins Np65 and Np55 are neuronal and synapse‐enriched immunoglobulin superfamily molecules that play important roles in a number of key neuronal…”
Get full text

Developing a Tanshinone IIA Memetic by Targeting MIOS to Regulate mTORC1 and Autophagy in Glioblastoma by Shinhmar, Sonia, Schaf, Judith, Lloyd Jones, Katie, Pardo, Olivier E, Beesley, Philip, Williams, Robin S B

“…Tanshinone IIA (T2A) is a bioactive compound that provides promise in the treatment of glioblastoma multiforme (GBM), with a range of molecular mechanisms…”
Get full text

The neuroplastin adhesion molecules are accessory proteins that chaperone the monocarboxylate transporter MCT2 to the neuronal cell surface by Wilson, Marieangela C, Kraus, Michaela, Marzban, Hassan, Sarna, Justyna R, Wang, Yisong, Hawkes, Richard, Halestrap, Andrew P, Beesley, Philip W

“…The neuroplastins np65 and np55 are two synapse-enriched immunoglobulin (Ig) superfamily adhesion molecules that contain 3 and 2 Ig domains respectively. Np65…”
Get full text

Genetically Induced Retrograde Amnesia of Associative Memories After Neuroplastin Ablation by Bhattacharya, Soumee, Herrera-Molina, Rodrigo, Sabanov, Victor, Ahmed, Tariq, Iscru, Emilia, Stöber, Franziska, Richter, Karin, Fischer, Klaus-Dieter, Angenstein, Frank, Goldschmidt, Jürgen, Beesley, Philip W, Balschun, Detlef, Smalla, Karl-Heinz, Gundelfinger, Eckart D, Montag, Dirk

“…ABSTRACT Background Neuroplastin cell recognition molecules have been implicated in synaptic plasticity. Polymorphisms in the regulatory region of the human…”
Get full text

Structure of Excitatory Synapses and GABAA Receptor Localization at Inhibitory Synapses Are Regulated by Neuroplastin-65 by Herrera-Molina, Rodrigo, Sarto-Jackson, Isabella, Montenegro-Venegas, Carolina, Heine, Martin, Smalla, Karl-Heinz, Seidenbecher, Constanze I., Beesley, Philip W., Gundelfinger, Eckart D., Montag, Dirk

“…Formation, maintenance, and activity of excitatory and inhibitory synapses are essential for neuronal network function. Cell adhesion molecules (CAMs) are…”
Get full text

Gamma secretase orthologs are required for lysosomal activity and autophagic degradation in Dictyostelium discoideum, independent of PSEN (presenilin) proteolytic function by Sharma, Devdutt, Otto, Grant, Warren, Eleanor C., Beesley, Philip, King, Jason S., Williams, Robin S. B.

“…Mutations in the γ-secretase complex are strongly associated with familial Alzheimer disease. Both proteolytic and non-proteolytic functions for the…”
Get full text

An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum by Ludtmann, Marthe H R, Otto, Grant P, Schilde, Christina, Chen, Zhi-Hui, Allan, Claire Y, Brace, Selina, Beesley, Philip W, Kimmel, Alan R, Fisher, Paul, Killick, Richard, Williams, Robin S B

“…Mutations in either of two presenilin genes can cause familial Alzheimer's disease. Presenilins have both proteolysis-dependent functions, as components of the…”
Get full text

Enhanced Sestrin expression through Tanshinone 2A treatment improves PI3K-dependent inhibition of glioma growth by Schaf, Judith, Shinhmar, Sonia, Zeng, Qingyu, Pardo, Olivier E., Beesley, Philip, Syed, Nelofer, Williams, Robin S. B.

“…Glioblastomas are a highly aggressive cancer type which respond poorly to current pharmaceutical treatments, thus novel therapeutic approaches need to be…”
Get full text

Reduced expression of the Ca(2+) transporter protein PMCA2 slows Ca(2+) dynamics in mouse cerebellar Purkinje neurones and alters the precision of motor coordination by Empson, Ruth M, Turner, Paul R, Nagaraja, Raghavendra Y, Beesley, Philip W, Knöpfel, Thomas

“…Cerebellar Purkinje neurones (PNs) express high levels of the plasma membrane calcium ATPase, PMCA2, a transporter protein critical for the clearance of…”
Get full text

SGCE missense mutations that cause myoclonus-dystonia syndrome impair ε-sarcoglycan trafficking to the plasma membrane: modulation by ubiquitination and torsinA by Esapa, Christopher T., Waite, Adrian, Locke, Matthew, Benson, Matthew A., Kraus, Michaela, McIlhinney, R.A. Jeffrey, Sillitoe, Roy V., Beesley, Philip W., Blake, Derek J.

“…Myoclonus-dystonia syndrome (MDS) is a genetically heterogeneous disorder characterized by myoclonic jerks often seen in combination with dystonia and…”
Get full text

Reduced expression of the Ca2+ transporter protein PMCA2 slows Ca2+ dynamics in mouse cerebellar Purkinje neurones and alters the precision of motor coordination by Empson, Ruth M., Turner, Paul R., Nagaraja, Raghavendra Y., Beesley, Philip W., Knöpfel, Thomas

“…Cerebellar Purkinje neurones (PNs) express high levels of the plasma membrane calcium ATPase, PMCA2, a transporter protein critical for the clearance of…”
Get full text

The cell adhesion molecule neuroplastin‐65 inhibits hippocampal long‐term potentiation via a mitogen‐activated protein kinase p38‐dependent reduction in surface expression of GluR1‐containing glutamate receptors by Empson, Ruth M., Buckby, Lucy E., Kraus, Michaela, Bates, Katharine J., Crompton, Mark R., Gundelfinger, Eckart D., Beesley, Philip W.

“…Neuroplastin‐65 is a brain‐specific, synapse‐enriched member of the immunoglobulin (Ig) superfamily of cell adhesion molecules. Previous studies highlighted…”
Get full text

Evidence for a Homodimeric Structure of Human Monocarboxylate Transporter 8 by Visser, W. Edward, Philp, Nancy J, van Dijk, Thamar B, Klootwijk, Wim, Friesema, Edith C. H, Jansen, Jurgen, Beesley, Philip W, Ianculescu, Alexandra G, Visser, Theo J

“…The human monocarboxylate transporter 8 (hMCT8) protein mediates transport of thyroid hormone across the plasma membrane. Association of hMCT8 mutations with…”
Get full text

The immunolocalization of the synaptic glycoprotein neuroplastin differs substantially between the human and the rodent brain by Bernstein, Hans-Gert, Smalla, Karl-Heinz, Bogerts, Bernhard, Gordon-Weeks, Phillip R, Beesley, Philip W, Gundelfinger, Eckart D, Kreutz, Michael R

“…Abstract Neuroplastin is a cell adhesion molecule of the immunoglobulin superfamily that exists in two splice isoforms, np65/np55, and that was reported to…”
Get full text

Coelomic expression of a novel bone morphogenetic protein in regenerating arms of the brittle star Amphiura filiformis by Bannister, Richard, McGonnell, Imelda M, Graham, Anthony, Thorndyke, Michael C, Beesley, Philip W

“…The bone morphogenetic proteins (BMPs) are a family of signalling molecules involved in numerous developmental processes including cell fate determination in…”
Get full text

Creating space and time for innovation - a methodology for building adaptation design appraisal using physics-based simulation tools and interactive multi-objective optimization by Shahi, Sheida, Beesley, Philip, Haas, Carl Thomas

“…PurposeIt is crucial to consider the multitude of possible building adaptation design strategies for improving the existing conditions of building stock as an…”
Get full text

Expression of the immunoglobulin superfamily neuroplastin adhesion molecules in adult and developing mouse cerebellum and their localisation to parasagittal stripes by Marzban, Hassan, Khanzada, Umme, Shabir, Saima, Hawkes, Richard, Langnaese, Kristina, Smalla, Karl-Heinz, Bockers, Tobias M., Gundelfinger, Eckart D., Gordon-Weeks, Phillip R., Beesley, Philip W.

“…Neuroplastin (np) 55 and 65 are immunoglobulin superfamily members that arise by alternative splicing of the same gene and have been implicated in long‐term…”
Get full text

SGCE missense mutations that cause myoclonus-dystonia syndrome impair -sarcoglycan trafficking to the plasma membrane: modulation by ubiquitination and torsinA by Esapa, Christopher T., Waite, Adrian, Locke, Matthew, Benson, Matthew A., Kraus, Michaela, McIlhinney, R.A. Jeffrey, Sillitoe, Roy V., Beesley, Philip W., Blake, Derek J.

“…Myoclonus-dystonia syndrome (MDS) is a genetically heterogeneous disorder characterized by myoclonic jerks often seen in combination with dystonia and…”
Get full text

Diffusive Thermal Architecture: New Work from the Hylozoic Series by Beesley, Philip

“…Could the use of high‐resolution image equipment and the thermodynamic patterns that they produce have a significant application in architectural design?…”
Get full text