Search Results - "Beesley, Jonathan"

On the Equivalence of Causal Propagators of the Dirac Equation in Vacuum-Destabilising External Fields by Beesley, Jonathan J.

“…In QED, an external electromagnetic field can be accounted for non-perturbatively by replacing the causal propagators used in Feynman diagram calculations with…”
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Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma by MacGregor, Stuart, Ong, Jue-Sheng, An, Jiyuan, Han, Xikun, Zhou, Tiger, Siggs, Owen M., Law, Matthew H., Souzeau, Emmanuelle, Sharma, Shiwani, Lynn, David J., Beesley, Jonathan, Sheldrick, Bronwyn, Mills, Richard A., Landers, John, Ruddle, Jonathan B., Graham, Stuart L., Healey, Paul R., White, Andrew J. R., Casson, Robert J., Best, Stephen, Grigg, John R, Goldberg, Ivan, Powell, Joseph E., Whiteman, David C., Radford-Smith, Graham L., Martin, Nicholas G., Montgomery, Grant W., Burdon, Kathryn P., Mackey, David A., Gharahkhani, Puya, Craig, Jamie E., Hewitt, Alex W.

“…Intraocular pressure (IOP) is currently the sole modifiable risk factor for primary open-angle glaucoma (POAG), one of the leading causes of blindness…”
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SNPs in lncRNA Regions and Breast Cancer Risk by Suvanto, Maija, Beesley, Jonathan, Blomqvist, Carl, Chenevix-Trench, Georgia, Khan, Sofia, Nevanlinna, Heli

“…Long non-coding RNAs (lncRNAs) play crucial roles in human physiology, and have been found to be associated with various cancers. Transcribed ultraconserved…”
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CRISPR screens identify gene targets at breast cancer risk loci by Tuano, Natasha K, Beesley, Jonathan, Manning, Murray, Shi, Wei, Perlaza-Jimenez, Laura, Malaver-Ortega, Luis F, Paynter, Jacob M, Black, Debra, Civitarese, Andrew, McCue, Karen, Hatzipantelis, Aaron, Hillman, Kristine, Kaufmann, Susanne, Sivakumaran, Haran, Polo, Jose M, Reddel, Roger R, Band, Vimla, French, Juliet D, Edwards, Stacey L, Powell, David R, Chenevix-Trench, Georgia, Rosenbluh, Joseph

“…Genome-wide association studies (GWAS) have identified > 200 loci associated with breast cancer risk. The majority of candidate causal variants are in…”
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Chromatin interactome mapping at 139 independent breast cancer risk signals by Beesley, Jonathan, Sivakumaran, Haran, Moradi Marjaneh, Mahdi, Lima, Luize G, Hillman, Kristine M, Kaufmann, Susanne, Tuano, Natasha, Hussein, Nehal, Ham, Sunyoung, Mukhopadhyay, Pamela, Kazakoff, Stephen, Lee, Jason S, Michailidou, Kyriaki, Barnes, Daniel R, Antoniou, Antonis C, Fachal, Laura, Dunning, Alison M, Easton, Douglas F, Waddell, Nicola, Rosenbluh, Joseph, Möller, Andreas, Chenevix-Trench, Georgia, French, Juliet D, Edwards, Stacey L

“…Genome-wide association studies have identified 196 high confidence independent signals associated with breast cancer susceptibility. Variants within these…”
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A Role for Common Genomic Variants in the Assessment of Familial Breast Cancer by Sawyer, Sarah, Mitchell, Gillian, McKinley, Joanne, Chenevix-Trench, Georgia, Beesley, Jonathan, Chen, Xiao Qing, Bowtell, David, Trainer, Alison H, Harris, Marion, Lindeman, Geoffrey J, James, Paul A

“…Genome-wide association studies have identified common genomic variants associated with increased susceptibility to breast cancer. In the general population,…”
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Non-coding RNAs underlie genetic predisposition to breast cancer by Moradi Marjaneh, Mahdi, Beesley, Jonathan, O'Mara, Tracy A, Mukhopadhyay, Pamela, Koufariotis, Lambros T, Kazakoff, Stephen, Hussein, Nehal, Fachal, Laura, Bartonicek, Nenad, Hillman, Kristine M, Kaufmann, Susanne, Sivakumaran, Haran, Smart, Chanel E, McCart Reed, Amy E, Ferguson, Kaltin, Saunus, Jodi M, Lakhani, Sunil R, Barnes, Daniel R, Antoniou, Antonis C, Dinger, Marcel E, Waddell, Nicola, Easton, Douglas F, Dunning, Alison M, Chenevix-Trench, Georgia, Edwards, Stacey L, French, Juliet D

“…Genetic variants identified through genome-wide association studies (GWAS) are predominantly non-coding and typically attributed to altered regulatory elements…”
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The importance of using public data to validate reported associations by Chenevix-Trench, Georgia, Beesley, Jonathan, Pharoah, Paul D P, Berchuck, Andrew

“…About the Authors: Georgia Chenevix-Trench Roles Conceptualization, Writing – original draft * E-mail: georgiaT@qimr.edu.au Affiliation: Queensland Institute…”
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A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase by Killedar, Anagha, Stutz, Michael D, Sobinoff, Alexander P, Tomlinson, Christopher G, Bryan, Tracy M, Beesley, Jonathan, Chenevix-Trench, Georgia, Reddel, Roger R, Pickett, Hilda A

“…The TERT-CLPTM1L region of chromosome 5p15.33 is a multi-cancer susceptibility locus that encodes the reverse transcriptase subunit, hTERT, of the telomerase…”
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Functional dissection of breast cancer risk-associated TERT promoter variants by Helbig, Sonja, Wockner, Leesa, Bouendeu, Annick, Hille-Betz, Ursula, McCue, Karen, French, Juliet D, Edwards, Stacey L, Pickett, Hilda A, Reddel, Roger R, Chenevix-Trench, Georgia, Dörk, Thilo, Beesley, Jonathan

“…The multi-cancer susceptibility locus at 5p15.33 includes , encoding the telomerase catalytic subunit. Genome-wide association studies (GWAS) have identified…”
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HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer by Da Silva, Leonard, Simpson, Peter T, Smart, Chanel E, Cocciardi, Sibylle, Waddell, Nic, Lane, Annette, Morrison, Brian J, Vargas, Ana Cristina, Healey, Sue, Beesley, Jonathan, Pakkiri, Pria, Parry, Suzanne, Kurniawan, Nyoman, Reid, Lynne, Keith, Patricia, Faria, Paulo, Pereira, Emilio, Skalova, Alena, Bilous, Michael, Balleine, Rosemary L, Do, Hongdo, Dobrovic, Alexander, Fox, Stephen, Franco, Marcello, Reynolds, Brent, Khanna, Kum Kum, Cummings, Margaret, Chenevix-Trench, Georgia, Lakhani, Sunil R

“…Metastases to the brain from breast cancer have a high mortality, and basal-like breast cancers have a propensity for brain metastases. However, the mechanisms…”
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ABCB1 (MDR 1) Polymorphisms and Progression-Free Survival among Women with Ovarian Cancer following Paclitaxel/Carboplatin Chemotherapy by Johnatty, Sharon E, Beesley, Jonathan, Paul, Jim, Fereday, Sian, Spurdle, Amanda B, Webb, Penelope M, Byth, Karen, Marsh, Sharon, McLeod, Howard, Harnett, Paul R, Brown, Robert, DeFazio, Anna, Chenevix-Trench, Georgia

“…Purpose: The human ABCB1 gene encodes P-glycoprotein, which transports a broad range of anticancer drugs, including paclitaxel. Although the functional…”
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Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers by Beesley, Jonathan, Pickett, Hilda A, Johnatty, Sharon E, Dunning, Alison M, Chen, Xiaoqing, Li, Jun, Michailidou, Kyriaki, Lu, Yi, Rider, David N, Palmieri, Rachel T, Stutz, Michael D, Lambrechts, Diether, Despierre, Evelyn, Lambrechts, Sandrina, Vergote, Ignace, Chang-Claude, Jenny, Nickels, Stefan, Vrieling, Alina, Flesch-Janys, Dieter, Wang-Gohrke, Shan, Eilber, Ursula, Bogdanova, Natalia, Antonenkova, Natalia, Runnebaum, Ingo B, Dörk, Thilo, Goodman, Marc T, Lurie, Galina, Wilkens, Lynne R, Matsuno, Rayna K, Kiemeney, Lambertus A, Aben, Katja K H, Marees, Tamara, Massuger, Leon F A G, Fridley, Brooke L, Vierkant, Robert A, Bandera, Elisa V, Olson, Sara H, Orlow, Irene, Rodriguez-Rodriguez, Lorna, Cook, Linda S, Le, Nhu D, Brooks-Wilson, Angela, Kelemen, Linda E, Campbell, Ian, Gayther, Simon A, Ramus, Susan J, Gentry-Maharaj, Aleksandra, Menon, Usha, Ahmed, Shahana, Baynes, Caroline, Pharoah, Paul D, Muir, Kenneth, Lophatananon, Artitaya, Chaiwerawattana, Arkom, Wiangnon, Surapon, Macgregor, Stuart, Easton, Douglas F, Reddel, Roger R, Goode, Ellen L, Chenevix-Trench, Georgia

“…Genetic variation at the TERT-CLPTM1L locus at 5p15.33 is associated with susceptibility to several cancers, including epithelial ovarian cancer (EOC). We have…”
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ESR1/SYNE1 Polymorphism and Invasive Epithelial Ovarian Cancer Risk: An Ovarian Cancer Association Consortium Study by Doherty, Jennifer A, Rossing, Mary Anne, Cushing-Haugen, Kara L, Chen, Chu, Van Den Berg, David J, Wu, Anna H, Pike, Malcolm C, Ness, Roberta B, Moysich, Kirsten, Chenevix-Trench, Georgia, Beesley, Jonathan, Webb, Penelope M, Chang-Claude, Jenny, Wang-Gohrke, Shan, Goodman, Marc T, Lurie, Galina, Thompson, Pamela J, Carney, Michael E, Hogdall, Estrid, Kjaer, Susanne Kruger, Hogdall, Claus, Goode, Ellen L, Cunningham, Julie M, Fridley, Brooke L, Vierkant, Robert A, Berchuck, Andrew, Moorman, Patricia G, Schildkraut, Joellen M, Palmieri, Rachel T, Cramer, Daniel W, Terry, Kathryn L, Yang, Hannah P, Garcia-Closas, Montserrat, Chanock, Stephen, Lissowska, Jolanta, Song, Honglin, Pharoah, Paul D P, Shah, Mitul, Perkins, Barbara, McGuire, Valerie, Whittemore, Alice S, Di Cioccio, Richard A, Gentry-Maharaj, Aleksandra, Menon, Usha, Gayther, Simon A, Ramus, Susan J, Ziogas, Argyrios, Brewster, Wendy, Anton-Culver, Hoda, Pearce, Celeste Leigh

“…We genotyped 13 single nucleotide polymorphisms (SNPs) in the estrogen receptor alpha gene ( ESR1 ) region in three population-based case-control studies of…”
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Large-scale cross-cancer fine-mapping of the 5p15.33 region reveals multiple independent signals by Chen, Hongjie, Majumdar, Arunabha, Wang, Lu, Kar, Siddhartha, Brown, Kevin M., Feng, Helian, Turman, Constance, Dennis, Joe, Easton, Douglas, Michailidou, Kyriaki, Simard, Jacques, Bishop, Timothy, Cheng, Iona C., Huyghe, Jeroen R., Schmit, Stephanie L., O’Mara, Tracy A., Spurdle, Amanda B., Gharahkhani, Puya, Schumacher, Johannes, Jankowski, Janusz, Gockel, Ines, Bondy, Melissa L., Houlston, Richard S., Jenkins, Robert B., Melin, Beatrice, Lesseur, Corina, Ness, Andy R., Diergaarde, Brenda, Olshan, Andrew F., Amos, Christopher I., Christiani, David C., Landi, Maria T., McKay, James D., Brossard, Myriam, Iles, Mark M., Law, Matthew H., MacGregor, Stuart, Beesley, Jonathan, Jones, Michelle R., Tyrer, Jonathan, Winham, Stacey J., Klein, Alison P., Petersen, Gloria, Li, Donghui, Wolpin, Brian M., Eeles, Rosalind A., Haiman, Christopher A., Kote-Jarai, Zsofia, Schumacher, Fredrick R., Brennan, Paul, Chanock, Stephen J., Gaborieau, Valerie, Purdue, Mark P., Pharoah, Paul, Hung, Rayjean J., Amundadottir, Laufey T., Kraft, Peter, Pasaniuc, Bogdan, Lindström, Sara

“…Genome-wide association studies (GWASs) have identified thousands of cancer risk loci revealing many risk regions shared across multiple cancers…”
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Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer by Saunus, Jodi M., De Luca, Xavier M., Northwood, Korinne, Raghavendra, Ashwini, Hasson, Alexander, McCart Reed, Amy E., Lim, Malcolm, Lal, Samir, Vargas, A. Cristina, Kutasovic, Jamie R., Dalley, Andrew J., Miranda, Mariska, Kalaw, Emarene, Kalita-de Croft, Priyakshi, Gresshoff, Irma, Al-Ejeh, Fares, Gee, Julia M. W., Ormandy, Chris, Khanna, Kum Kum, Beesley, Jonathan, Chenevix-Trench, Georgia, Green, Andrew R., Rakha, Emad A., Ellis, Ian O., Nicolau, Dan V., Simpson, Peter T., Lakhani, Sunil R.

“…Intratumoral heterogeneity is caused by genomic instability and phenotypic plasticity, but how these features co-evolve remains unclear. SOX10 is a neural…”
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Genome-wide association study of paclitaxel and carboplatin disposition in women with epithelial ovarian cancer by Gao, Bo, Lu, Yi, Nieuweboer, Annemieke J. M., Xu, Hongmei, Beesley, Jonathan, Boere, Ingrid, de Graan, Anne-Joy M., de Bruijn, Peter, Gurney, Howard, J. Kennedy, Catherine, Chiew, Yoke-Eng, Johnatty, Sharon E., Beale, Philip, Harrison, Michelle, Luccarini, Craig, Conroy, Don, Mathijssen, Ron H. J., R. Harnett, Paul, Balleine, Rosemary L., Chenevix-Trench, Georgia, Macgregor, Stuart, de Fazio, Anna

“…Identifying single nucleotide polymorphisms (SNPs) that influence chemotherapy disposition may help to personalize cancer treatment and limit toxicity…”
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Immune Cell Associations with Cancer Risk by Palomero, Luis, Galván-Femenía, Ivan, de Cid, Rafael, Espín, Roderic, Barnes, Daniel R., CIMBA, Blommaert, Eline, Gil-Gil, Miguel, Falo, Catalina, Stradella, Agostina, Ouchi, Dan, Roso-Llorach, Albert, Violan, Concepció, Peña-Chilet, María, Dopazo, Joaquín, Extremera, Ana Isabel, García-Valero, Mar, Herranz, Carmen, Mateo, Francesca, Mereu, Elisabetta, Beesley, Jonathan, Chenevix-Trench, Georgia, Roux, Cecilia, Mak, Tak, Brunet, Joan, Hakem, Razq, Gorrini, Chiara, Antoniou, Antonis C., Lázaro, Conxi, Pujana, Miquel Angel

“…Proper immune system function hinders cancer development, but little is known about whether genetic variants linked to cancer risk alter immune cells. Here, we…”
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Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer by GAYTHER, Simon A, HONGLIN SONG, BLACKER, Jan, DICIOCCIO, Richard, MCGUIRE, Valerie, WEBB, Penelope M, BEESLEY, Jonathan, GREEN, Adele C, WHITEMAN, David C, GOODMAN, Marc T, LURIE, Galina, CARNEY, Michael E, RAMUS, Susan J, MODUGNO, Francesmary, NESS, Roberta B, EDWARDS, Robert P, MOYSICH, Kirsten B, GOODE, Ellen L, COUCH, Fergus J, CUNNINGHAM, Julie M, SELLERS, Thomas A, WU, Anna H, PIKE, Malcolm C, KRUGER KJAER, Susan, IVERSEN, Edwin S, MARKS, Jeffrey R, GARCIA-CLOSAS, Montserrat, BRINTON, Louise, LISSOWSKA, Jolanta, PEPLONSKA, Beata, EASTON, Douglas F, JACOBS, Ian, PONDER, Bruce A. J, SCHILDKRAUT, Joellen, WHITTEMORE, Alice S, PEARCE, C. Leigh, CHENEVIX-TRENCH, Georgia, BERCHUCK, Andrew, PHAROAH, Paul D. P, QUAYE, Lydia, TYRER, Jonathan, SHADFORTH, Danielle, HOGDALL, Estrid, HOGDALL, Claus

“…High-risk susceptibility genes explain <40% of the excess risk of familial ovarian cancer. Therefore, other ovarian cancer susceptibility genes are likely to…”
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Association Between Single-Nucleotide Polymorphisms in Hormone Metabolism and DNA Repair Genes and Epithelial Ovarian Cancer: Results from Two Australian Studies and an Additional Validation Set by BEESLEY, Jonathan, JORDAN, Susan J, GAYTHER, Simon A, PHAROAH, Paul D. P, WEBB, Penelope M, CHENEVIX-TRENCH, Georgia, SPURDLE, Amanda B, HONGLIN SONG, RAMUS, Susan J, KRUGER KJAER, Suzanne, HOGDALL, Estrid, DICIOCCIO, Richard A, MCGUIRE, Valerie, WHITTEMORE, Alice S

“…Although some high-risk ovarian cancer genes have been identified, it is likely that common low penetrance alleles exist that confer some increase in ovarian…”
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