Search Results - "Beerman, A."

Diagnosis of plant diseases using the Nanopore sequencing platform by Chalupowicz, L., Dombrovsky, A., Gaba, V., Luria, N., Reuven, M., Beerman, A., Lachman, O., Dror, O., Nissan, G., Manulis‐Sasson, S.

“…Reliable detection and identification of plant pathogens are essential for disease control strategies. Diagnostic methods commonly used to detect plant…”
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Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses by Kennedy, Daniel R, Ju, Jianhua, Shen, Ben, Beerman, Terry A

“…The ability of the radiomimetic anticancer enediyne C-1027 to induce ataxia-telangiectasia mutated (ATM) and ATM and Rad3-related (ATR)-independent damage…”
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The Radiomimetic Enediyne C-1027 Induces Unusual DNA Damage Responses to Double-Strand Breaks by Kennedy, Daniel R, Beerman, Terry A

“…Cells lacking the protein kinase ataxia telangiectasia mutated (ATM) have defective responses to DNA double-strand breaks (DSBs), including an inability to…”
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Cellular Responses to the DNA Strand-scission Enediyne C-1027 Can Be Independent of ATM, ATR, and DNA-PK Kinases by Dziegielewski, Jaroslaw, Beerman, Terry A.

“…The current paradigm based upon ionizing radiation (IR) studies states that cells deficient in either ataxia-telangiectasia-mutated kinase (ATM) or related…”
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The effects of soy milk and isoflavone supplements on cognitive performance in healthy, postmenopausal women by Fournier, L R, Ryan Borchers, T A, Robison, L M, Wiediger, M, Park, J S, Chew, B P, McGuire, M K, Sclar, D A, Skaer, T L, Beerman, K A

“…The decline in estrogen concentrations in women after menopause can contribute to health related changes including impairments in cognition, especially memory…”
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Inhibition of RecBCD Enzyme by Antineoplastic DNA Alkylating Agents by Dziegielewska, Barbara, Beerman, Terry A., Bianco, Piero R.

“…To understand how bulky adducts might perturb DNA helicase function, three distinct DNA-binding agents were used to determine the effects of DNA alkylation on…”
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DNA crosslinking and biological activity of a hairpin polyamide–chlorambucil conjugate by Wang, Yong‐Dong, Dziegielewski, Jaroslaw, Wurtz, Nicholas R., Dziegielewska, Barbara, Dervan, Peter B., Beerman, Terry A.

“…A prototype of a novel class of DNA alkylating agents, which combines the DNA crosslinking moiety chlorambucil (Chl) with a sequence‐selective hairpin…”
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An extraction-free method by which a single slot blot can be used to quantify intracellular DNA damage (crosslinks or strand breaks) and changes in DNA damage response proteins or replication by McHugh, Mary, Beerman, Terry

“…We report an extraction-free assay in which the same slot blot membrane can be used to assess total genomic DNA damage (i.e., crosslinks or strand breaks) and…”
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Inhibition of Transcription Factor-DNA Complexes and Gene Expression by a Microgonotropen by White, Christine M., Satz, Alexander L., Bruice, Thomas C., Beerman, Terry A.

“…Developing minor groove-binding drugs to selectively inhibit transcription factor (TF)/DNA interactions and accompanying gene expression is a current goal in…”
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Cellular uptake of N-methylpyrrole/ N-methylimidazole polyamide-dye conjugates by Belitsky, Jason M, Leslie, Stephanie J, Arora, Paramjit S, Beerman, Terry A, Dervan, Peter B

“…The cellular uptake and localization properties of DNA binding N-methylpyrrole/ N-methylimidazole polyamide–dye conjugates in a variety of living cells have…”
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Hedamycin, a DNA alkylator, induces γH2AX and chromosome aberrations: Involvement of phosphatidylinositol 3-kinase–related kinases and DNA replication fork movement by Tu, Lan Chun, Matsui, Sei ichi, Beerman, Terry A.

“…Genotoxic treatments, such as UV light, camptothecin, and adozelesin, stall DNA replication and subsequently generate DNA strand breaks. Typically, DNA breaks…”
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Cell-free and Cellular Activities of a DNA Sequence Selective Hairpin Polyamide-CBI Conjugate by Wang, Yong-Dong, Dziegielewski, Jaroslaw, Chang, Aileen Y, Dervan, Peter B, Beerman, Terry A

“…Alkylating agents are generally highly reactive with DNA but demonstrate limited DNA sequence selectivity. In contrast, synthetic pyrrole-imidazole polyamides…”
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SV40 DNA Replication Inhibition by the Monofunctional DNA Alkylator Et743 by Dziegielewska, Barbara, Kowalski, David, Beerman, Terry A

“…Ecteinascidin 743 (Et743) is a highly cytotoxic anticancer agent isolated from the squirt Ecteinascidia turbinate, which alkylates DNA in the minor groove at…”
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DNA damage effects of a polyamide-CBI conjugate in SV40 virions by Philips, Brian J, Chang, Aileen Y, Dervan, Peter B, Beerman, Terry A

“…Polyamides are a class of synthetic molecules that exhibit high-affinity, sequence-specific reversible binding in the DNA minor groove but are incapable of…”
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DNA damage responses triggered by a highly cytotoxic monofunctional DNA alkylator, hedamycin, a pluramycin antitumor antibiotic by Tu, Lan Chun, Melendy, Thomas, Beerman, Terry A

“…Long-term exposure (72 h) to hedamycin, a monofunctional DNA alkylator of the pluramycin class of antitumor antibiotics, decreased growth of mammalian cells by…”
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Effects of Minor Groove Binding Drugs on the Interaction of TATA Box Binding Protein and TFIIA with DNA by Chiang, Shu-Yuan, Welch, John, Rauscher, Frank J, Beerman, Terry A

“…TBP (TATA box binding protein), a general transcription factor required for proper initiation of gene expression by RNA polymerase II, and minor groove binding…”
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Adozelesin Triggers DNA Damage Response Pathways and Arrests SV40 DNA Replication through Replication Protein A Inactivation by Liu, Jen-Sing, Kuo, Shu-Ru, McHugh, Mary M., Beerman, Terry A., Melendy, Thomas

“…The cyclopropylpyrroloindole anti-cancer drug, adozelesin, binds to and alkylates DNA. Treatment of human cells with low levels of adozelesin results in potent…”
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The antitumor enediyne C-1027 alters cell cycle progression and induces chromosomal aberrations and telomere dysfunction by MCHUGH, Mary M, GAWRON, Loretta S, MATSUI, Sei-Ichi, BEERMAN, Terry A

“…This study examined the extent of chromosome instability induced in cultured human colon carcinoma HCT116 cells by the antitumor radiomimetic enediyne…”
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Bleomycin-Induced Alterations in DNA Replication:  Relationship to DNA Damage by Dziegielewski, Jaroslaw, Melendy, Thomas, Beerman, Terry A

“…Bleomycin (BLM), a well-known DNA scission agent, is assumed to inhibit intracellular DNA replication by damaging the DNA template (cis-acting mechanism),…”
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Evaluation of the Effectiveness of DNA-Binding Drugs To Inhibit Transcription Using the c-fos Serum Response Element as a Target by White, Christine M, Heidenreich, Olaf, Nordheim, Alfred, Beerman, Terry A

“…Previous work has demonstrated that sequence-selective DNA-binding drugs can inhibit transcription factors from binding to their target sites on gene…”
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