Neural evidence for impaired action selection in right hemiparetic cerebral palsy

Abstract Recent studies suggest that in addition to low-level motor impairments, individuals with hemiparetic cerebral palsy (HCP) are characterized by anticipatory action planning deficits as well. In the present EEG study we investigated the neural and temporal dynamics of action planning in parti...

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Bibliographic Details
Published in:	Brain research Vol. 1349; pp. 56 - 67
Main Authors:	van Elk, M, Crajé, C, Beeren, M.E.G.V, Steenbergen, B, van Schie, H.T, Bekkering, H
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 19-08-2010 Elsevier
Subjects:	Action selection Adolescent Analysis of Variance Biological and medical sciences Brain Mapping Cerebral Palsy - complications Cerebral Palsy - pathology Electroencephalography - methods Event-related potentials Evoked Potentials - physiology Female Functional Laterality - physiology Gyrus Cinguli - physiopathology Hand Strength - physiology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hemiparetic cerebral palsy Humans Male Medical sciences Motor planning Movement Disorders - etiology Movement Disorders - pathology Nervous system (semeiology, syndromes) Neurology Reaction Time - physiology Rotation Statistics as Topic Young Adult Action selection Event-related potentials P2 Motor planning Hemiparetic cerebral palsy Human Cerebral palsy Nervous system diseases Central nervous system disease Electrophysiology Event evoked potential Cerebral disorder
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Summary:	Abstract Recent studies suggest that in addition to low-level motor impairments, individuals with hemiparetic cerebral palsy (HCP) are characterized by anticipatory action planning deficits as well. In the present EEG study we investigated the neural and temporal dynamics of action planning in participants with right-sided HCP ( n = 10) and in left-handed control subjects ( n = 10). An anticipatory planning task was used in which participants were required to grasp and rotate a hexagonal knob over different angles (60°, 120° or 180°). At a behavioral level, participants with HCP were slower in their movements and often selected an inappropriate grip when grasping the object. At a neural level, individuals with HCP showed a strong reduction in the amplitude of the P2 component, likely reflecting an impaired process of action selection. In addition, a strong correlation was observed between the P2 amplitude and grasping and rotation times. The P2 component was localized to sources in the dorsal posterior cingulate cortex (dPCC), an area that is known to be involved in orienting visual body parts in space. Together these findings suggest that anticipatory planning deficits in cerebral palsy arise mainly due to an impaired process of action selection.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2010.06.055