Search Results - "Beer, Thomas"

Model-based analysis of high shear wet granulation from batch to continuous processes in pharmaceutical production – A critical review by Kumar, Ashish, Gernaey, Krist V., Beer, Thomas De, Nopens, Ingmar

“…[Display omitted] The manufacturing of pharmaceutical dosage forms, which has traditionally been a batch-wise process, is now also transformed into a series of…”
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Evaluation of an external lubrication system implemented in a compaction simulator by de Backere, Cedrine, De Beer, Thomas, Vervaet, Chris, Vanhoorne, Valérie

“…[Display omitted] The internal blending of magnesium stearate is often associated with decreasing tensile strengths and longer disintegration and dissolution…”
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Process analytical tools for monitoring, understanding, and control of pharmaceutical fluidized bed granulation: A review by Burggraeve, Anneleen, Monteyne, Tinne, Vervaet, Chris, Remon, Jean Paul, Beer, Thomas De

“…This review gives a detailed overview of the in-line applied process analyzers, contributing to improved fluid bed granulation understanding, modeling, control…”
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Exploring experiences of times without care and encounters in dementia: protocol for a living and adaptive evidence map by Hirt, Julian, Adlbrecht, Laura, Maurer, Carola, Beer, Thomas

“…IntroductionIndividuals with dementia spend most of the day without care, without encounters, and usually without activity. Although this has been proven in…”
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Formulation Optimization of Freeze-Dried Long-Circulating Liposomes and In-Line Monitoring of the Freeze-Drying Process Using an NIR Spectroscopy Tool by Sylvester, Bianca, Porfire, Alina, Van Bockstal, Pieter-Jan, Porav, Sebastian, Achim, Marcela, Beer, Thomas De, Tomuţă, Ioan

“…The effect of lyoprotectant type and concentration on the stability of freeze-dried prednisolone sodium phosphate-loaded long-circulating liposomes was…”
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In-depth experimental analysis of pharmaceutical twin-screw wet granulation in view of detailed process understanding by Verstraeten, Maxim, Van Hauwermeiren, Daan, Lee, Kai, Turnbull, Neil, Wilsdon, David, am Ende, Mary, Doshi, Pankaj, Vervaet, Chris, Brouckaert, Davinia, Mortier, Séverine T.F.C., Nopens, Ingmar, Beer, Thomas De

“…[Display omitted] Twin-screw wet granulation is gaining increasing interest within the pharmaceutical industry for the continuous manufacturing of solid oral…”
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Thermal Imaging as a Noncontact Inline Process Analytical Tool for Product Temperature Monitoring during Continuous Freeze-Drying of Unit Doses by Van Bockstal, Pieter-Jan, Corver, Jos, De Meyer, Laurens, Vervaet, Chris, De Beer, Thomas

“…Freeze-drying is a well-established technique to improve the stability of biopharmaceuticals which are unstable in aqueous solution. To obtain an elegant dried…”
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Influence of raw material properties upon critical quality attributes of continuously produced granules and tablets by Fonteyne, Margot, Wickström, Henrika, Peeters, Elisabeth, Vercruysse, Jurgen, Ehlers, Henrik, Peters, Björn-Hendrik, Remon, Jean Paul, Vervaet, Chris, Ketolainen, Jarkko, Sandler, Niklas, Rantanen, Jukka, Naelapää, Kaisa, Beer, Thomas De

“…[Display omitted] Continuous manufacturing gains more and more interest within the pharmaceutical industry. The International Conference of Harmonisation (ICH)…”
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MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer by Casciano, Jessica C., Perry, Caroline, Cohen-Nowak, Adam J., Miller, Katelyn D., Vande Voorde, Johan, Zhang, Qifeng, Chalmers, Susan, Sandison, Mairi E., Liu, Qin, Hedley, Ann, McBryan, Tony, Tang, Hsin-Yao, Gorman, Nicole, Beer, Thomas, Speicher, David W., Adams, Peter D., Liu, Xuefeng, Schlegel, Richard, McCarron, John G., Wakelam, Michael J. O., Gottlieb, Eyal, Kossenkov, Andrew V., Schug, Zachary T.

“…Background Recent studies have suggested that fatty acid oxidation (FAO) is a key metabolic pathway for the growth of triple negative breast cancers (TNBCs),…”
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Potential of Near-Infrared Chemical Imaging as Process Analytical Technology Tool for Continuous Freeze-Drying by Brouckaert, Davinia, De Meyer, Laurens, Vanbillemont, Brecht, Van Bockstal, Pieter-Jan, Lammens, Joris, Mortier, Séverine, Corver, Jos, Vervaet, Chris, Nopens, Ingmar, De Beer, Thomas

“…Near-infrared chemical imaging (NIR-CI) is an emerging tool for process monitoring because it combines the chemical selectivity of vibrational spectroscopy…”
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DCAF15 control of cohesin dynamics sustains acute myeloid leukemia by Grothusen, Grant P., Chang, Renxu, Cao, Zhendong, Zhou, Nan, Mittal, Monika, Datta, Arindam, Wulfridge, Phillip, Beer, Thomas, Wang, Baiyun, Zheng, Ning, Tang, Hsin-Yao, Sarma, Kavitha, Greenberg, Roger A., Shi, Junwei, Busino, Luca

“…The CRL4-DCAF15 E3 ubiquitin ligase complex is targeted by the aryl-sulfonamide molecular glues, leading to neo-substrate recruitment, ubiquitination, and…”
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Real-time assessment of critical quality attributes of a continuous granulation process by Fonteyne, Margot, Vercruysse, Jurgen, Díaz, Damián Córdoba, Gildemyn, Delphine, Vervaet, Chris, Remon, Jean Paul, Beer, Thomas De

“…There exists the intention to shift pharmaceutical manufacturing of solid dosage forms from traditional batch production towards continuous production. The…”
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Solution of bivariate aggregation population balance equation: a comparative study by Singh, Mehakpreet, Kaur, Gurmeet, De Beer, Thomas, Nopens, Ingmar

“…The present work shows a comparative study of two different numerical methods for solving bivariate aggregation population balance equations. In particular, we…”
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Visualization and Process Understanding of Material Behavior in the Extrusion Barrel during a Hot-Melt Extrusion Process Using Raman Spectroscopy by Saerens, Lien, Vervaet, Chris, Remon, Jean-Paul, De Beer, Thomas

“…The aim of this research was to improve understanding of material behavior in pharmaceutical hot-melt extrusion by implementing a Raman probe in each section…”
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Conceptual framework for model-based analysis of residence time distribution in twin-screw granulation by Kumar, Ashish, Vercruysse, Jurgen, Vanhoorne, Valérie, Toiviainen, Maunu, Panouillot, Pierre-Emmanuel, Juuti, Mikko, Vervaet, Chris, Remon, Jean Paul, Gernaey, Krist V., Beer, Thomas De, Nopens, Ingmar

“…[Display omitted] Twin-screw granulation is a promising continuous alternative for traditional batchwise wet granulation processes. The twin-screw granulator…”
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Process Analytical Technology for continuous manufacturing of solid-dosage forms by Fonteyne, Margot, Vercruysse, Jurgen, De Leersnyder, Fien, Van Snick, Bernd, Vervaet, Chris, Remon, Jean Paul, De Beer, Thomas

“…•Pharmaceutical production is switching from batch towards continuous processing.•Implementation of Process Analytical Technology in continuous production…”
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Release characteristics of polyurethane tablets containing dicarboxylic acids as release modifiers – a case study with diprophylline by Claeys, Bart, Bruyn, Sander De, Hansen, Laurent, Beer, Thomas De, Remon, Jean Paul, Vervaet, Chris

“…[Display omitted] The influence of several dicarboxylic acids on the release characteristics of polyurethane tablets with a high drug load was investigated…”
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Exploring the Experiences of Times Without Care and Encounters in Persons With Dementia in the Swiss and German Nursing Home and Domiciliary Care Settings: Protocol for an Ethnographic Multimethods Study by Beer, Thomas, Hirt, Julian, Adlbrecht, Laura, Lindwedel, Ulrike, Dammert, Matthias, Maurer, Carola, Kliegel, Matthias, König, Peter, Bleses, Helma M

“…Background:Persons with dementia spend a large part of the day without care and encounters, often without activity, as confirmed by numerous studies. However,…”
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Continuous twin screw granulation: A complex interplay between formulation properties, process settings and screw design by Portier, Christoph, Pandelaere, Kenny, Delaet, Urbain, Vigh, Tamas, Di Pretoro, Giustino, De Beer, Thomas, Vervaet, Chris, Vanhoorne, Valérie

“…[Display omitted] Due to the numerous advantages over batch manufacturing, continuous manufacturing techniques such as twin screw wet granulation are rapidly…”
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Phenolic Compounds and Anti‐oxidant Capacity of Twelve Morphologically Heterogeneous Bamboo species by Hoyweghen, Laura Van, Beer, Thomas De, Deforce, Dieter, Heyerick, Arne

“…INTRODUCTION: Despite the growing interest in the use of bamboo for both food and health‐related applications because it provides a rich source of…”
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