Search Results - "Beer, T. M."

Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study by Slovin, S.F., Higano, C.S., Hamid, O., Tejwani, S., Harzstark, A., Alumkal, J.J., Scher, H.I., Chin, K., Gagnier, P., McHenry, M.B., Beer, T.M.

“…This phase I/II study in patients with metastatic castration-resistant prostate cancer (mCRPC) explored ipilimumab as monotherapy and in combination with…”
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Skeletal-related events significantly impact health-related quality of life in metastatic castration-resistant prostate cancer: data from PREVAIL and AFFIRM trials by Saad, F, Ivanescu, C, Phung, D, Loriot, Y, Abhyankar, S, Beer, T M, Tombal, B, Holmstrom, S

“…Background: We investigated the impact of skeletal-related events (SREs) on health-related quality of life (HRQoL) in patients with metastatic…”
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Implementation of a Process Analytical Technology System in a Freeze-Drying Process Using Raman Spectroscopy for In-Line Process Monitoring by De Beer, T. R. M, Allesø, M, Goethals, F, Coppens, A, Vander Heyden, Y, Lopez De Diego, H, Rantanen, J, Verpoort, F, Vervaet, C, Remon, J. P, Baeyens, W. R. G

“…The aim of the present study was to propose a strategy for the implementation of a Process Analytical Technology system in freeze-drying processes. Mannitol…”
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Phase II study of weekly docetaxel in symptomatic androgen-independent prostate cancer by Beer, T. M., Pierce, W. C., Lowe, B. A., Henner, W. D.

“…Summary Background This study sought to define the activity and toxicity of weekly docetaxel in patients with androgen-independent prostate cancer and…”
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Phase II study of first-line sagopilone plus prednisone in patients with castration-resistant prostate cancer: a phase II study of the Department of Defense Prostate Cancer Clinical Trials Consortium by Beer, T M, Smith, D C, Hussain, A, Alonso, M, Wang, J, Giurescu, M, Roth, K, Wang, Y

“…Background: Preclinical studies in prostate cancer (PC) models demonstrated the anti-tumour activity of the first fully synthetic epothilone, sagopilone. This…”
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Freeze-drying of live virus vaccines: A review by Hansen, L.J.J, Daoussi, R, Vervaet, C, Remon, J.-P, De Beer, T.R.M

“…Abstract Freeze-drying is the preferred method for stabilizing live, attenuated virus vaccines. After decades of research on several aspects of the process…”
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Multiple cycles of intermittent chemotherapy in metastatic androgen-independent prostate cancer by BEER, T. M, GARZOTTO, M, HENNER, W. D, EILERS, K. M, WERSINGER, E. M

“…Recently, completed phase III studies demonstrated a survival benefit for a fixed number of cycles of docetaxel-containing chemotherapy treatment of…”
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In-line and real-time process monitoring of a freeze drying process using Raman and NIR spectroscopy as complementary process analytical technology (PAT) tools by De Beer, T R M, Vercruysse, P, Burggraeve, A, Quinten, T, Ouyang, J, Zhang, X, Vervaet, C, Remon, J P, Baeyens, W R G

“…The aim of the present study was to examine the complementary properties of Raman and near infrared (NIR) spectroscopy as PAT tools for the fast, noninvasive,…”
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Intermittent chemotherapy in metastatic androgen-independent prostate cancer by BEER, T. M, GARZOTTO, M, HENNER, W. D, EILERS, K. M, WERSINGER, E. M

“…Intermittent use of chemotherapy for androgen-independent prostate cancer (AIPC) instead of treatment until disease progression may reduce toxicity. We…”
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Development and validation of a prognostic model for overall survival in chemotherapy-naïve men with metastatic castration-resistant prostate cancer by Armstrong, A.J., Lin, P., Higano, C.S., Sternberg, C.N., Sonpavde, G., Tombal, B., Templeton, A.J., Fizazi, K., Phung, D., Wong, E.K., Krivoshik, A., Beer, T.M.

“…Prognostic models are needed that reflect contemporary practice for men with metastatic castration-resistant prostate cancer (mCRPC). We sought to identify…”
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Efficacy and safety of enzalutamide in patients 75 years or older with chemotherapy-naive metastatic castration-resistant prostate cancer: results from PREVAIL by Graff, J.N., Baciarello, G., Armstrong, A.J., Higano, C.S., Iversen, P., Flaig, T.W., Forer, D., Parli, T., Phung, D., Tombal, B., Beer, T.M., Sternberg, C.N.

“…Prostate cancer disproportionately affects older men. Because age affects treatment decisions, it is important to understand the efficacy and tolerability of…”
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Radiographic progression with nonrising PSA in metastatic castration-resistant prostate cancer: post hoc analysis of PREVAIL by Bryce, A H, Alumkal, J J, Armstrong, A, Higano, C S, Iversen, P, Sternberg, C N, Rathkopf, D, Loriot, Y, de Bono, J, Tombal, B, Abhyankar, S, Lin, P, Krivoshik, A, Phung, D, Beer, T M

“…Background: Advanced prostate cancer is a phenotypically diverse disease that evolves through multiple clinical courses. PSA level is the most widely used…”
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Imatinib mesylate and zoledronic acid in androgen-independent prostate cancer by Tiffany, N.M, Wersinger, E.M, Garzotto, M, Beer, T.M

“…To determine the safety and efficacy of zoledronic acid (Zometa) combined with imatinib mesylate (Gleevec) in patients with bone pain due to…”
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Raman spectroscopy as a process analytical technology (PAT) tool for the in-line monitoring and understanding of a powder blending process by De Beer, T.R.M., Bodson, C., Dejaegher, B., Walczak, B., Vercruysse, P., Burggraeve, A., Lemos, A., Delattre, L., Heyden, Y. Vander, Remon, J.P., Vervaet, C., Baeyens, W.R.G.

“…The aim of this study is to propose a strategy to implement a PAT system in the blending step of pharmaceutical production processes. It was examined whether…”
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Delayed therapy with curative intent in a contemporary prostate cancer watchful‐waiting cohort by El‐Geneidy, M., Garzotto, M., Panagiotou, I., Hsieh, Y.‐C., Mori, M., Peters, L., Klein, T., Beer, T.M.

“…OBJECTIVE To identify predictors of delayed therapy with curative intent, an increasingly common option in contemporary patients with prostate cancer who…”
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Influence of polyethylene glycol/polyethylene oxide on the release characteristics of sustained-release ethylcellulose mini-matrices produced by hot-melt extrusion: in vitro and in vivo evaluations by Verhoeven, E., De Beer, T.R.M., Schacht, E., Van den Mooter, G., Remon, J.P., Vervaet, C.

“…Mini-matrices with release-sustaining properties were developed by hot-melt extrusion (diameter 3 mm, height 2 mm) using metoprolol tartrate as model drug…”
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Influence of formulation and process parameters on the release characteristics of ethylcellulose sustained-release mini-matrices produced by hot-melt extrusion by Verhoeven, E., De Beer, T.R.M., Van den Mooter, G., Remon, J.P., Vervaet, C.

“…Mini-matrices (multiple unit dosage form) with release-sustaining properties were developed by hot-melt extrusion (cylindrical die: 3 mm) using metoprolol…”
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Perpetuating effects of androgen deficiency on insulin resistance by Cameron, J L, Jain, R, Rais, M, White, A E, Beer, T M, Kievit, P, Winters-Stone, K, Messaoudi, I, Varlamov, O

“…Background/Objectives: Androgen deprivation therapy (ADT) is commonly used for treatment of prostate cancer but is associated with side effects, such as…”
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Optimization of a pharmaceutical freeze-dried product and its process using an experimental design approach and innovative process analyzers by De Beer, T.R.M., Wiggenhorn, M., Hawe, A., Kasper, J.C., Almeida, A., Quinten, T., Friess, W., Winter, G., Vervaet, C., Remon, J.P.

“…The aim of the present study was to examine the possibilities/advantages of using recently introduced in-line spectroscopic process analyzers (Raman, NIR and…”
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Importance of Using Complementary Process Analyzers for the Process Monitoring, Analysis, and Understanding of Freeze Drying by De Beer, T. R. M, Wiggenhorn, M, Veillon, R, Debacq, C, Mayeresse, Y, Moreau, B, Burggraeve, A, Quinten, T, Friess, W, Winter, G, Vervaet, C, Remon, J. P, Baeyens, W. R. G

“…The aim of the present paper is to demonstrate the importance of using complementary process analyzers (PAT tools) for the process monitoring, analysis, and…”
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