Search Results - "Beeley, Nigel R.A."

Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity by SMITH, Brian M, SMITH, Jeffrey M, DIPANJAN SENGUPTA, THOMSEN, William J, SALDANA, Hazel R, WHELAN, Kevin T, MENZAGHI, Frederique, WEBB, Robert R, BEELEY, Nigel R. A, TSAI, James H, SCHULTZ, Jeffrey A, GILSON, Charles A, ESTRADA, Scott A, CHEN, Rita R, PARK, Douglas M, PRIETO, Emily B, GALLARDO, Charlemagne S

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Can peptides be mimicked? by Beeley, Nigel R.A

“…The biological activity of peptides is of enormous interest to the pharmaceutical industry, but endogenous peptides themselves typically have some limitations…”
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6-LB: GPR119 Agonist PRM A Increases Glucagon Response to Hypoglycemia in Rats by KWOK, DAVID W.K., ALEXANDER, DIANE, BEELEY, NIGEL R.A., KELLEY, DAVID

“…Glucagon (Gcg) is crucial in the counter-regulatory response (CRR) to hypoglycemia yet this is severely impaired in T1D. This pathophysiology was recognized 50…”
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Discovery and Structure−Activity Relationship of (1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a Selective Serotonin 5-HT2C Receptor Agonist for the Treatment of Obesity by Smith, Brian M, Smith, Jeffrey M, Tsai, James H, Schultz, Jeffrey A, Gilson, Charles A, Estrada, Scott A, Chen, Rita R, Park, Douglas M, Prieto, Emily B, Gallardo, Charlemagne S, Sengupta, Dipanjan, Dosa, Peter I, Covel, Jon A, Ren, Albert, Webb, Robert R, Beeley, Nigel R. A, Martin, Michael, Morgan, Michael, Espitia, Stephen, Saldana, Hazel R, Bjenning, Christina, Whelan, Kevin T, Grottick, Andrew J, Menzaghi, Frederique, Thomsen, William J

“…The synthesis and SAR of a novel 3-benzazepine series of 5-HT2C agonists is described. Compound 7d (lorcaserin, APD356) was identified as one of the more…”
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An in vivo model for screening peptidomimetic inhibitors of gelatinase A by Chander, S K, Antoniw, P, Beeley, N R, Boyce, B, Crabbe, T, Docherty, A J, Leonard, J, Mason, B, Millar, K, Millican, A T

“…Gelatinase A, a matrix metalloproteinase, is frequently associated with human solid tumors, and its secretion and activation in the tumor milieu is considered…”
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Discovery of 1-[3-(4-Bromo-2-methyl-2 H -pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (Nelotanserin) and Related 5-Hydroxytryptamine 2A Inverse Agonists for the Treatment of Insomnia by Teegarden, Bradley R., Li, Hongmei, Jayakumar, Honnappa, Strah-Pleynet, Sonja, Dosa, Peter I., Selaya, Susan D., Kato, Naomi, Elwell, Katie H., Davidson, Jarrod, Cheng, Karen, Saldana, Hazel, Frazer, John M., Whelan, Kevin, Foster, Jonathan, Espitia, Stephan, Webb, Robert R., Beeley, Nigel R. A., Thomsen, William, Morairty, Stephen R., Kilduff, Thomas S., Al-Shamma, Hussien A.

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Discovery and SAR of new benzazepines as potent and selective 5-HT 2C receptor agonists for the treatment of obesity by Smith, Brian M., Smith, Jeffrey M., Tsai, James H., Schultz, Jeffrey A., Gilson, Charles A., Estrada, Scott A., Chen, Rita R., Park, Douglas M., Prieto, Emily B., Gallardo, Charlemagne S., Sengupta, Dipanjan, Thomsen, William J., Saldana, Hazel R., Whelan, Kevin T., Menzaghi, Frederique, Webb, Robert R., Beeley, Nigel R.A.

“…The synthesis and SAR of a 3-benzazepine series of selective 5-HT 2C agonists is described. We report on the synthesis, biological evaluation and…”
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Medicinal Chemistry – An Introduction by Beeley, Nigel R.A

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Corrigendum by Beeley, Nigel R.A.

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GPCRs: an update on structural approaches to drug discovery by Beeley, Nigel R.A., Sage, Carleton

“…G-protein-coupled receptors (GPCRs) are a major opportunity for drug discovery in the post-genomic era. There are thought to be more than 500 therapeutically…”
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Improved tumor targeting with chemically cross-linked recombinant antibody fragments by KING, D. J, TURNER, A, MILLAR, K, MILLICAN, T. A, BOYCE, B. A, ANTONIW, P, MOUNTAIN, A, BEGENT, R. H. J, SHOCHAT, D, YARRANTON, G. T, FARNSWORTH, A. P. H, ADAIR, J. R, OWENS, R. J, PEDLEY, R. B, BALDOCK, D, PROUDFOOT, K. A, LAWSON, A. D. G, BEELEY, N. R. A

“…The construction and use of recombinant chimeric and later fully humanized (CDR-grafted) antibodies to tumor-associated antigens has reduced the immune…”
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Book review by Beeley, Nigel R.A

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Book review: Peptidomimetic Protocols in the series Methods in Molecular Medicine (Vol. 23) (Walker, J.M., series ed.), edited by W.M. Kazmierski by Beeley, Nigel R.A

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