Search Results - "Beelen, Robert H.J"

Human macrophage polarization in vitro : Maturation and activation methods compared by Vogel, Daphne Y.S, Glim, Judith E, Stavenuiter, Andrea W.D, Breur, Marjolein, Heijnen, Priscilla, Amor, Sandra, Dijkstra, Christine D, Beelen, Robert H.J

“…Abstract Macrophages form a heterogeneous cell population displaying multiple functions, and can be polarized into pro- (M1) or anti-inflammatory (M2)…”
Get full text

Platelet derived growth factor-CC secreted by M2 macrophages induces alpha-smooth muscle actin expression by dermal and gingival fibroblasts by Glim, Judith E, Niessen, Frank B, Everts, Vincent, van Egmond, Marjolein, Beelen, Robert H.J

“…Abstract Dermal wounds can heal detrimentally by formation of excess fibrosis or hypertrophic scarring. These phenomena are normally absent in the oral mucosa…”
Get full text

Subendothelial Heparan Sulfate Proteoglycans Become Major L-Selectin and Monocyte Chemoattractant Protein-1 Ligands upon Renal Ischemia/Reperfusion by Celie, Johanna W.A.M, Rutjes, Niels W.P, Keuning, Eelco D, Soininen, Raija, Heljasvaara, Ritva, Pihlajaniemi, Taina, Dräger, Angelika M, Zweegman, Sonja, Kessler, Floortje L, Beelen, Robert H.J, Florquin, Sandrine, Aten, Jan, van den Born, Jacob

“…Leukocyte infiltration into inflamed tissues is considered to involve sequential steps of rolling over the endothelium, adhesion, and transmigration. In this…”
Get full text

Macrophages in skin injury and repair by Delavary, Babak Mahdavian, van der Veer, Willem M, van Egmond, Marjolein, Niessen, Frank B, Beelen, Robert H.J

“…Abstract After recruitment to the wound bed, monocytes differentiate into macrophages. Macrophages play a central role in all stages of wound healing and…”
Get full text

Tumor infiltrating macrophages reduce development of peritoneal colorectal carcinoma metastases by van der Bij, Gerben J, Bögels, Marijn, Oosterling, Steven J, Kroon, Jeffrey, Schuckmann, Dénise T.M, de Vries, Helga E, Meijer, Sybren, Beelen, Robert H.J, van Egmond, Marjolein

“…Abstract Macrophages generally constitute a major component of tumor stroma, and possess either tumor growth promoting or inhibiting capabilities. Classically…”
Get full text

Extracellular matrix components of oral mucosa differ from skin and resemble that of foetal skin by Glim, Judith E, Everts, Vincent, Niessen, Frank B, Ulrich, Magda M, Beelen, Robert H.J

“…Abstract Objective Wounds of both the oral mucosa and early-to-mid gestation foetuses have a propensity to heal scarless. Repair of skin wounds in adults,…”
Get full text

Immune-Regulatory Molecule CD69 Controls Peritoneal Fibrosis by Liappas, Georgios, González-Mateo, Guadalupe Tirma, Sánchez-Díaz, Raquel, Lazcano, Juan José, Lasarte, Sandra, Matesanz-Marín, Adela, Zur, Rafal, Ferrantelli, Evelina, Ramírez, Laura García, Aguilera, Abelardo, Fernández-Ruiz, Elena, Beelen, Robert H J, Selgas, Rafael, Sánchez-Madrid, Francisco, Martín, Pilar, López-Cabrera, Manuel

“…Patients with ESRD undergoing peritoneal dialysis develop progressive peritoneal fibrosis, which may lead to technique failure. Recent data point to…”
Get full text

Effluent and serum protein N-glycosylation is associated with inflammation and peritoneal membrane transport characteristics in peritoneal dialysis patients by Ferrantelli, Evelina, Farhat, Karima, Ederveen, Agnes L. Hipgrave, Reiding, Karli R., Beelen, Robert H. J., van Ittersum, Frans J., Wuhrer, Manfred, Dotz, Viktoria

“…Mass spectrometric glycomics was used as an innovative approach to identify biomarkers in serum and dialysate samples from peritoneal dialysis (PD) patients…”
Get full text

Immunoglobulin A: FcαRI Interactions Induce Neutrophil Migration Through Release of Leukotriene B4 by van der Steen, Lydia, Tuk, Cornelis W, Bakema, Jantine E, Kooij, Gijs, Reijerkerk, Arie, Vidarsson, Gestur, Bouma, Gerd, Kraal, Georg, de Vries, Helga E, Beelen, Robert H.J, van Egmond, Marjolein

“…Background & Aims Exacerbations of ulcerative colitis (UC) are dominated by massive neutrophil influx in the lamina propria with concomitant mucosal…”
Get full text

The number of immune cells is lower in healthy oral mucosa compared to skin and does not increase after scarring by Glim, Judith E, Beelen, Robert H.J, Niessen, Frank B, Everts, Vincent, Ulrich, Magda M.W

“…Highlights • The number of several immune cells was compared between human skin and oral mucosa. • Oral mucosa had significantly fewer immune cells than skin…”
Get full text

Vitamin D Attenuates Endothelial Dysfunction in Uremic Rats and Maintains Human Endothelial Stability by Vila Cuenca, Marc, Ferrantelli, Evelina, Meinster, Elisa, Pouw, Stephan M, Kovačević, Igor, de Menezes, Renee X, Niessen, Hans W, Beelen, Robert H J, Hordijk, Peter L, Vervloet, Marc G

“…Background Dysfunctional endothelium may contribute to the development of cardiovascular complications in chronic kidney disease ( CKD ). Supplementation with…”
Get full text

A Novel Rat Model of Vitamin D Deficiency: Safe and Rapid Induction of Vitamin D and Calcitriol Deficiency without Hyperparathyroidism by Dusso, Adriana S., Vervloet, Marc G., ter Wee, Piet M., Vila Cuenca, M., Keuning, E. D., Ferrantelli, E., Arcidiacono, Maria Vittoria, Stavenuiter, Andrea W. D., Beelen, Robert H. J.

“…Vitamin D deficiency is associated with a range of clinical disorders. To study the mechanisms involved and improve treatments, animal models are tremendously…”
Get full text

Effects of Conversion to a Bicarbonate/Lactate-Buffered, Neutral-PH, LOW-GDP PD Regimen in Prevalent PD: A 2-Year Randomized Clinical Trial by Farhat, Karima, Douma, Caroline E., Ferrantelli, E., ter Wee, Pieter M., Beelen, Robert H.J., van Ittersum, Frans J.

“…Background The use of pH-neutral peritoneal dialysis (PD) fluids low in glucose degradation products (GDP) may better preserve the peritoneal membrane and have…”
Get full text

BMP-7 blocks mesenchymal conversion of mesothelial cells and prevents peritoneal damage induced by dialysis fluid exposure by Loureiro, Jesús, Schilte, Margot, Aguilera, Abelardo, Albar-Vizcaíno, Patricia, Ramírez-Huesca, Marta, Pérez-Lozano, M. Luisa, González-Mateo, Guadalupe, Aroeira, Luiz S., Selgas, Rafael, Mendoza, Lorea, Ortiz, Alberto, Ruíz-Ortega, Marta, van den Born, Jacob, Beelen, Robert H.J., López-Cabrera, Manuel

“…Background. During peritoneal dialysis (PD), mesothelial cells (MC) undergo an epithelial-to-mesenchymal transition (EMT), and this process is associated with…”
Get full text

FACTORS CONTRIBUTING TO PERITONEAL TISSUE REMODELING IN PERITONEAL DIALYSIS by SCHILTE, Margot N, CELIE, Johanna W. A. M, TER WEE, Piet M, BEELEN, Robert H. J, VAN DEN BORN, Jacob

“…Peritoneal dialysis (PD) is associated with functional and structural changes of the peritoneal membrane. In this review we describe factors contributing to…”
Get full text

Tubular epithelial syndecan-1 maintains renal function in murine ischemia/reperfusion and human transplantation by Celie, Johanna W A M, Katta, Kiran K, Adepu, Saritha, Melenhorst, Wynand B W H, Reijmers, Rogier M, Slot, Edith M, Beelen, Robert H J, Spaargaren, Marcel, Ploeg, Rutger J, Navis, Gerjan, van der Heide, Jaap J Homan, van Dijk, Marcory C R F, van Goor, Harry, van den Born, Jacob

“…Syndecan-1, a heparan sulfate proteoglycan, has an important role in wound healing by binding several growth factors and cytokines. As these processes are also…”
Get more information

Experimentally induced liver metastases from colorectal cancer can be prevented by mononuclear phagocyte-mediated monoclonal antibody therapy by van der Bij, Gerben J, Bögels, Marijn, Otten, Marielle A, Oosterling, Steven J, Kuppen, Peter J, Meijer, Sybren, Beelen, Robert H.J, van Egmond, Marjolein

“…Background & Aims Development of liver metastases is a frequent complication in patients with colorectal cancer (CRC), even after successful resection of the…”
Get full text

Addressing Peritoneal Dialysis: In Vitro PD Models, In Vivo Rodent PD Model, Clinical Biobanks, and Underutilization of PD by Beelen, Robert H. J., Fraser, Donald J., Rutherford, Peter, Witowski, Janusz

Get full text

The presence of tissue renin-angiotensin system components in human burn wounds and scars by Akershoek, Johanneke J., Vlig, Marcel, Brouwer, Katrien, Talhout, Wendy, Beelen, Robert H.J., Middelkoop, Esther, Ulrich, Magda M.W.

“…[Display omitted] •Different components of the local renin angiotensin system are expressed in burn wound eschar and scar tissue.•Between 3 and 5 weeks after…”
Get full text

Carcinoma origin dictates differential skewing of monocyte function by Bögels, Marijn, Braster, Rens, Nijland, Philip G., Gül, Nuray, van de Luijtgaarden, Wendy, Fijneman, Remond J.A., Meijer, Gerrit A., Jimenez, Connie R., Beelen, Robert H.J., van Egmond, Marjolein

“…Macrophages are versatile cells, which phenotype is profoundly influenced by their environment. Pro-inflammatory classically activated or M1 macrophages, and…”
Get full text