Search Results - "Beelen, Robert"

Human macrophage polarization in vitro : Maturation and activation methods compared by Vogel, Daphne Y.S, Glim, Judith E, Stavenuiter, Andrea W.D, Breur, Marjolein, Heijnen, Priscilla, Amor, Sandra, Dijkstra, Christine D, Beelen, Robert H.J

“…Abstract Macrophages form a heterogeneous cell population displaying multiple functions, and can be polarized into pro- (M1) or anti-inflammatory (M2)…”
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Macrophages in skin injury and repair by Delavary, Babak Mahdavian, van der Veer, Willem M, van Egmond, Marjolein, Niessen, Frank B, Beelen, Robert H.J

“…Abstract After recruitment to the wound bed, monocytes differentiate into macrophages. Macrophages play a central role in all stages of wound healing and…”
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Detrimental dermal wound healing: What can we learn from the oral mucosa? by Glim, Judith E., van Egmond, Marjolein, Niessen, Frank B., Everts, Vincent, Beelen, Robert H. J.

“…Wounds in adults are frequently accompanied by scar formation. This scar can become fibrotic due to an imbalance between extracellular matrix (ECM) synthesis…”
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Platelet derived growth factor-CC secreted by M2 macrophages induces alpha-smooth muscle actin expression by dermal and gingival fibroblasts by Glim, Judith E, Niessen, Frank B, Everts, Vincent, van Egmond, Marjolein, Beelen, Robert H.J

“…Abstract Dermal wounds can heal detrimentally by formation of excess fibrosis or hypertrophic scarring. These phenomena are normally absent in the oral mucosa…”
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The Perioperative Period is an Underutilized Window of Therapeutic Opportunity in Patients With Colorectal Cancer by VAN DER BIJ, Gerben J, OOSTERLING, Steven J, BEELEN, Robert H. J, MEIJER, Sybren, COFFEY, John C, VAN EGMOND, Marjolein

“…In this review, we address the underlying mechanisms by which surgery augments metastases outgrowth and how these insights can be used to develop perioperative…”
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The dipeptide alanyl-glutamine ameliorates peritoneal fibrosis and attenuates IL-17 dependent pathways during peritoneal dialysis by Ferrantelli, Evelina, Liappas, Georgios, Vila Cuenca, Marc, Keuning, Eelco D, Foster, Thomas L, Vervloet, Marc G, Lopéz-Cabrera, Manuel, Beelen, Robert H J

“…Peritoneal dialysis (PD) can result in chronic inflammation and progressive peritoneal membrane damage. Alanyl-Glutamine (Ala-Gln), a dipeptide with…”
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Extracellular matrix components of oral mucosa differ from skin and resemble that of foetal skin by Glim, Judith E, Everts, Vincent, Niessen, Frank B, Ulrich, Magda M, Beelen, Robert H.J

“…Abstract Objective Wounds of both the oral mucosa and early-to-mid gestation foetuses have a propensity to heal scarless. Repair of skin wounds in adults,…”
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The number of immune cells is lower in healthy oral mucosa compared to skin and does not increase after scarring by Glim, Judith E, Beelen, Robert H.J, Niessen, Frank B, Everts, Vincent, Ulrich, Magda M.W

“…Highlights • The number of several immune cells was compared between human skin and oral mucosa. • Oral mucosa had significantly fewer immune cells than skin…”
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Effluent and serum protein N-glycosylation is associated with inflammation and peritoneal membrane transport characteristics in peritoneal dialysis patients by Ferrantelli, Evelina, Farhat, Karima, Ederveen, Agnes L. Hipgrave, Reiding, Karli R., Beelen, Robert H. J., van Ittersum, Frans J., Wuhrer, Manfred, Dotz, Viktoria

“…Mass spectrometric glycomics was used as an innovative approach to identify biomarkers in serum and dialysate samples from peritoneal dialysis (PD) patients…”
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Immune-Regulatory Molecule CD69 Controls Peritoneal Fibrosis by Liappas, Georgios, González-Mateo, Guadalupe Tirma, Sánchez-Díaz, Raquel, Lazcano, Juan José, Lasarte, Sandra, Matesanz-Marín, Adela, Zur, Rafal, Ferrantelli, Evelina, Ramírez, Laura García, Aguilera, Abelardo, Fernández-Ruiz, Elena, Beelen, Robert H J, Selgas, Rafael, Sánchez-Madrid, Francisco, Martín, Pilar, López-Cabrera, Manuel

“…Patients with ESRD undergoing peritoneal dialysis develop progressive peritoneal fibrosis, which may lead to technique failure. Recent data point to…”
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Monocytes and macrophages as nanomedicinal targets for improved diagnosis and treatment of disease by Lameijer, Marnix A, Tang, Jun, Nahrendorf, Matthias, Beelen, Robert H J, Mulder, Willem J M

“…The important role of monocytes and macrophages in diseases like cancer and atherosclerosis has started to get uncovered in the last decade. In addition,…”
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A Novel Rat Model of Vitamin D Deficiency: Safe and Rapid Induction of Vitamin D and Calcitriol Deficiency without Hyperparathyroidism by Dusso, Adriana S., Vervloet, Marc G., ter Wee, Piet M., Vila Cuenca, M., Keuning, E. D., Ferrantelli, E., Arcidiacono, Maria Vittoria, Stavenuiter, Andrea W. D., Beelen, Robert H. J.

“…Vitamin D deficiency is associated with a range of clinical disorders. To study the mechanisms involved and improve treatments, animal models are tremendously…”
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Targeting FcαRI on polymorphonuclear cells induces tumor cell killing through autophagy by Bakema, Jantine E, Ganzevles, Sonja H, Fluitsma, Donna M, Schilham, Marco W, Beelen, Robert H J, Valerius, Thomas, Lohse, Stefan, Glennie, Martin J, Medema, Jan Paul, van Egmond, Marjolein

“…Neutrophils are the most abundant circulating FcR-expressing WBCs with potent cytotoxic ability. Currently, they are recognized as promising effector cells for…”
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Healthy human second-trimester fetal skin is deficient in leukocytes and associated homing chemokines by Walraven, Mariëlle, Talhout, Wendy, Beelen, Robert H.J., van Egmond, Marjolein, Ulrich, Magda M.W.

“…The lack of immune cells in mid‐gestational fetal skin is often mentioned as a key factor underlying scarless healing. However, the scarless healing ability is…”
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Experimentally induced liver metastases from colorectal cancer can be prevented by mononuclear phagocyte-mediated monoclonal antibody therapy by van der Bij, Gerben J, Bögels, Marijn, Otten, Marielle A, Oosterling, Steven J, Kuppen, Peter J, Meijer, Sybren, Beelen, Robert H.J, van Egmond, Marjolein

“…Background & Aims Development of liver metastases is a frequent complication in patients with colorectal cancer (CRC), even after successful resection of the…”
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Inhibited early immunologic response is associated with hypertrophic scarring by Butzelaar, Liselotte, Schooneman, Dennis P. M., Soykan, Ezgi A., Talhout, Wendy, Ulrich, Magda M. W., van den Broek, Lenie J., Gibbs, Susan, Beelen, Robert H. J., Mink van der Molen, Aebele B., Niessen, Frank B.

“…This study aimed to examine changes in the inflammatory response in early hypertrophic compared to normal wound healing. The immune system is thought to be…”
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BMP-7 blocks mesenchymal conversion of mesothelial cells and prevents peritoneal damage induced by dialysis fluid exposure by Loureiro, Jesús, Schilte, Margot, Aguilera, Abelardo, Albar-Vizcaíno, Patricia, Ramírez-Huesca, Marta, Pérez-Lozano, M. Luisa, González-Mateo, Guadalupe, Aroeira, Luiz S., Selgas, Rafael, Mendoza, Lorea, Ortiz, Alberto, Ruíz-Ortega, Marta, van den Born, Jacob, Beelen, Robert H.J., López-Cabrera, Manuel

“…Background. During peritoneal dialysis (PD), mesothelial cells (MC) undergo an epithelial-to-mesenchymal transition (EMT), and this process is associated with…”
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Going into surgery: Risk factors for hypertrophic scarring by Butzelaar, Lisolette, Soykan, Ezgi A., Galindo Garre, Francisca, Beelen, Robert H.J., Ulrich, Magda M., Niessen, Frank B., Mink van der Molen, Aebele B.

“…ABSTRACT The aim of this study was to examine the association between possible risk factors for excessive scarring and the formation of hypertrophic scars…”
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FACTORS CONTRIBUTING TO PERITONEAL TISSUE REMODELING IN PERITONEAL DIALYSIS by SCHILTE, Margot N, CELIE, Johanna W. A. M, TER WEE, Piet M, BEELEN, Robert H. J, VAN DEN BORN, Jacob

“…Peritoneal dialysis (PD) is associated with functional and structural changes of the peritoneal membrane. In this review we describe factors contributing to…”
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Tubular epithelial syndecan-1 maintains renal function in murine ischemia/reperfusion and human transplantation by Celie, Johanna W A M, Katta, Kiran K, Adepu, Saritha, Melenhorst, Wynand B W H, Reijmers, Rogier M, Slot, Edith M, Beelen, Robert H J, Spaargaren, Marcel, Ploeg, Rutger J, Navis, Gerjan, van der Heide, Jaap J Homan, van Dijk, Marcory C R F, van Goor, Harry, van den Born, Jacob

“…Syndecan-1, a heparan sulfate proteoglycan, has an important role in wound healing by binding several growth factors and cytokines. As these processes are also…”
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