Search Results - "Beekman, M"

When earlier and fatter is better by Beekman, M.

Get full text

To mine or not to mine—asked the Drosophila larva by Beekman, M.

Get full text

Correction: To mine or not to mine—asked the Drosophila larva by Beekman, M.

Get full text

The social life of silk wasps by Beekman, M.

Get full text

A new (irregular) section and the IUSSI accounts by Beekman, M.

Get full text

What if you can control whom your queen mates with? by Beekman, M.

Get full text

Workers require more cognitive skills than soldiers, queens and kings by Beekman, M.

Get full text

Logical-qubit operations in an error-detecting surface code by Marques, J. F., Varbanov, B. M., Moreira, M. S., Ali, H., Muthusubramanian, N., Zachariadis, C., Battistel, F., Beekman, M., Haider, N., Vlothuizen, W., Bruno, A., Terhal, B. M., DiCarlo, L.

“…Future fault-tolerant quantum computers will require storing and processing quantum data in logical qubits. Here we realize a suite of logical operations on a…”
Get full text

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients by Schwank, Gerald, Koo, Bon-Kyoung, Sasselli, Valentina, Dekkers, Johanna F., Heo, Inha, Demircan, Turan, Sasaki, Nobuo, Boymans, Sander, Cuppen, Edwin, van der Ent, Cornelis K., Nieuwenhuis, Edward E.S., Beekman, Jeffrey M., Clevers, Hans

“…Single murine and human intestinal stem cells can be expanded in culture over long time periods as genetically and phenotypically stable epithelial organoids…”
Get full text

High-resolution 3D imaging of fixed and cleared organoids by Dekkers, Johanna F., Alieva, Maria, Wellens, Lianne M., Ariese, Hendrikus C. R., Jamieson, Paul R., Vonk, Annelotte M., Amatngalim, Gimano D., Hu, Huili, Oost, Koen C., Snippert, Hugo J. G., Beekman, Jeffrey M., Wehrens, Ellen J., Visvader, Jane E., Clevers, Hans, Rios, Anne C.

“…In vitro 3D organoid systems have revolutionized the modeling of organ development and diseases in a dish. Fluorescence microscopy has contributed to the…”
Get full text

High-Fidelity Controlled- Z Gate with Maximal Intermediate Leakage Operating at the Speed Limit in a Superconducting Quantum Processor by Negîrneac, V., Ali, H., Muthusubramanian, N., Battistel, F., Sagastizabal, R., Moreira, M. S., Marques, J. F., Vlothuizen, W. J., Beekman, M., Zachariadis, C., Haider, N., Bruno, A., DiCarlo, L.

“…Simple tuneup of fast two-qubit gates is essential for the scaling of quantum processors. We introduce the sudden variant (SNZ) of the net zero scheme…”
Get full text

CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank by Geurts, Maarten H., de Poel, Eyleen, Amatngalim, Gimano D., Oka, Rurika, Meijers, Fleur M., Kruisselbrink, Evelien, van Mourik, Peter, Berkers, Gitte, de Winter-de Groot, Karin M., Michel, Sabine, Muilwijk, Danya, Aalbers, Bente L., Mullenders, Jasper, Boj, Sylvia F., Suen, Sylvia W.F., Brunsveld, Jesse E., Janssens, Hettie M., Mall, Marcus A., Graeber, Simon Y., van Boxtel, Ruben, van der Ent, Cornelis K., Beekman, Jeffrey M., Clevers, Hans

“…Adenine base editing (ABE) enables enzymatic conversion from A-T into G-C base pairs. ABE holds promise for clinical application, as it does not depend on the…”
Get full text

Readthrough compounds for nonsense mutations: bridging the translational gap by Spelier, Sacha, van Doorn, Eveline P.M., van der Ent, Cornelis K., Beekman, Jeffrey M., Koppens, Martijn A.J.

“…Approximately 10% of all pathological mutations are nonsense mutations which are responsible for the most severe cases of genetic diseases but for which no…”
Get full text

A functional CFTR assay using primary cystic fibrosis intestinal organoids by Dekkers, Johanna F, Wiegerinck, Caroline L, de Jonge, Hugo R, Bronsveld, Inez, Janssens, Hettie M, de Winter-de Groot, Karin M, Brandsma, Arianne M, de Jong, Nienke W M, Bijvelds, Marcel J C, Scholte, Bob J, Nieuwenhuis, Edward E S, van den Brink, Stieneke, Clevers, Hans, van der Ent, Cornelis K, Middendorp, Sabine, Beekman, Jeffrey M

“…Building on earlier work, Dekkers et al . describe the first application of their intestinal organoid culture technology to the study of human disease, in this…”
Get full text

Olfactory associative learning in the Australian stingless bee Tetragonula carbonaria by Ludowici, M., Beekman, M., Gloag, R.

“…Flower-visiting social insects use a variety of cues to help them learn and recall which flowers are high-quality resources, including the flower odour. In…”
Get full text

Pharmacological analysis of CFTR variants of cystic fibrosis using stem cell-derived organoids by Chen, Kevin G., Zhong, Pingyu, Zheng, Wei, Beekman, Jeffrey M.

“…[Display omitted] •Analyzing CFTR mutations in patients with cystic fibrosis (CF).•Predicting drug response for CF patients via organoid assays.•Modulating…”
Get full text

Secondary integrated analysis of multi-tissue transcriptomic responses to a combined lifestyle intervention in older adults from the GOTO nonrandomized trial by Bogaards, F. A., Gehrmann, T., Beekman, M., Lakenberg, N., Suchiman, H. E. D., de Groot, C. P. G. M., Reinders, M. J. T., Slagboom, P. E.

“…Molecular effects of lifestyle interventions are typically studied in a single tissue. Here, we perform a secondary analysis on the sex-specific effects of the…”
Get full text

MiMIR: R-shiny application to infer risk factors and endpoints from Nightingale Health’s 1H-NMR metabolomics data by Bizzarri, D, Reinders, M J T, Beekman, M, Slagboom, P E, van den Akker, E B

“…Abstract Motivation 1H-NMR metabolomics is rapidly becoming a standard resource in large epidemiological studies to acquire metabolic profiles in large numbers…”
Get full text

Genetic differentiation at extreme latitudes in the socially plastic sweat bee Halictus rubicundus by Michels, Bas A, Beekman, Mariska M, Field, Jeremy, Gruber, Jodie, Pannebakker, Bart A, Savill, Charlotte, Boulton, Rebecca A

“…The sweat bee Halictus rubicundus is an important pollinator with a large latitudinal range and many potential barriers to gene flow. Alongside typical…”
Get full text

Neuropsychiatric systemic lupus erythematosus: Lessons learned from magnetic resonance imaging by Luyendijk, J., Steens, S. C. A., Ouwendijk, W. J. N., Steup‐Beekman, G. M., Bollen, E. L. E. M., van der Grond, J., Huizinga, T. W. J., Emmer, B. J., van Buchem, M. A.

“…Objective The clinical manifestations of nervous system involvement in systemic lupus erythematosus (neuropsychiatric SLE [NPSLE]) are highly diverse, and…”
Get full text