Search Results - "Beek, Ermond Van"

Effect of PLGA NP size on efficiency to target traumatic brain injury by Cruz, Luis J., Stammes, Marieke A., Que, Ivo, van Beek, Ermond R., Knol-Blankevoort, Vicky T., Snoeks, Thomas J.A., Chan, Alan, Kaijzel, Eric L., Löwik, Clemens W.G.M.

“…Necrotic cell death occurs exclusively under pathological conditions, such as ischemic diseases. Necrosis imaging is of diagnostic value and enables early…”
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Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation by Zhang, Yonghui, Cao, Rong, Yin, Fenglin, Hudock, Michael P, Guo, Rey-Ting, Krysiak, Kilannin, Mukherjee, Sujoy, Gao, Yi-Gui, Robinson, Howard, Song, Yongcheng, No, Joo Hwan, Bergan, Kyle, Leon, Annette, Cass, Lauren, Goddard, Amanda, Chang, Ting-Kai, Lin, Fu-Yang, Beek, Ermond Van, Papapoulos, Socrates, Wang, Andrew H.-J, Kubo, Tadahiko, Ochi, Mitsuo, Mukkamala, Dushyant, Oldfield, Eric

“…Considerable effort has focused on the development of selective protein farnesyl transferase (FTase) and protein geranylgeranyl transferase (GGTase) inhibitors…”
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Dual-wavelength imaging of tumor progression by activatable and targeting near-infrared fluorescent probes in a bioluminescent breast cancer model by Xie, Bang-Wen, Mol, Isabel M, Keereweer, Stijn, van Beek, Ermond R, Que, Ivo, Snoeks, Thomas J A, Chan, Alan, Kaijzel, Eric L, Löwik, Clemens W G M

“…Bioluminescence imaging (BLI) has shown its appeal as a sensitive technique for in vivo whole body optical imaging. However, the development of injectable…”
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Optical Imaging of Treatment-Related Tumor Cell Death Using a Heat Shock Protein-90 Alkylator by Park, Danielle, Xie, Bang-Wen, Van Beek, Ermond R, Blankevoort, Vicky, Que, Ivo, Löwik, Clemens W. G. M, Hogg, Philip J

“…The ability to assess in near-real time the tumor cell killing efficacy of chemotherapy regimens would improve patient treatment and survival. An ineffective…”
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The Necrosis-Avid Small Molecule HQ4-DTPA as a Multimodal Imaging Agent for Monitoring Radiation Therapy-Induced Tumor Cell Death by Stammes, Marieke A, Maeda, Azusa, Bu, Jiachuan, Scollard, Deborah A, Kulbatski, Iris, Medeiros, Philip J, Sinisi, Riccardo, Dubikovskaya, Elena A, Snoeks, Thomas J A, van Beek, Ermond R, Chan, Alan B, Löwik, Clemens W G M, DaCosta, Ralph S

“…Most effective antitumor therapies induce tumor cell death. Non-invasive, rapid and accurate quantitative imaging of cell death is essential for monitoring…”
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Dissociation of Angiogenesis and Osteoclastogenesis During Endochondral Bone Formation in Neonatal Mice by Deckers, Martine M. L., Van Beek, Ermond R., Van Der Pluijm, Gabri, Wetterwald, Antoinette, Van Der Wee‐Pals, Lianne, Cecchini, Marco G., Papapoulos, Socrates E., Löwik, Clemens W. G. M.

“…Invasion of the mineralized matrix by endothelial cells and osteoclasts is a key event in endochondral bone formation. To examine the putative role of…”
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Farnesyl Pyrophosphate Synthase Is the Molecular Target of Nitrogen-Containing Bisphosphonates by van Beek, Ermond, Pieterman, Elsbet, Cohen, Louis, Löwik, Clemens, Papapoulos, Socrates

“…Bisphosphonates (Bps), inhibitors of osteoclastic bone resorption, are used in the treatment of skeletal disorders. Recent evidence indicated that farnesyl…”
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Necrosis avid near infrared fluorescent cyanines for imaging cell death and their use to monitor therapeutic efficacy in mouse tumor models by Xie, Bangwen, Stammes, Marieke A, van Driel, Pieter B A A, Cruz, Luis J, Knol-Blankevoort, Vicky T, Löwik, Martijn A M, Mezzanotte, Laura, Que, Ivo, Chan, Alan, van den Wijngaard, Jeroen P H M, Siebes, Maria, Gottschalk, Sven, Razansky, Daniel, Ntziachristos, Vasilis, Keereweer, Stijn, Horobin, Richard W, Hoehn, Mathias, Kaijzel, Eric L, van Beek, Ermond R, Snoeks, Thomas J A, Löwik, Clemens W G M

“…Quantification of tumor necrosis in cancer patients is of diagnostic value as the amount of necrosis is correlated with disease prognosis and it could also be…”
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Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging by Stammes, Marieke A., Knol-Blankevoort, Vicky T., Cruz, Luis J., Feitsma, Hans R. I. J., Mezzanotte, Laura, Cordfunke, Robert A., Sinisi, Riccardo, Dubikovskaya, Elena A., Maeda, Azusa, DaCosta, Ralph S., Bierau, Katja, Chan, Alan, Kaijzel, Eric L., Snoeks, Thomas J. A., van Beek, Ermond R., Löwik, Clemens W. G. M.

“…Purpose Recently we showed that a number of carboxylated near-infrared fluorescent (NIRF) cyanine dyes possess strong necrosis avid properties in vitro as well…”
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The Role of Geranylgeranylation in Bone Resorption and Its Suppression by Bisphosphonates in Fetal Bone Explants In Vitro: A Clue to the Mechanism of Action of Nitrogen‐Containing Bisphosphonates by Van Beek, Ermond, Löwik, Clemens, Van Der Pluijm, Gabri, Papapoulos, Socrates

“…Bisphosphonates, synthetic compounds used in the treatment of skeletal disorders, suppress osteoclast‐mediated bone resorption by a yet unidentified mechanism…”
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Multicolor Fluorescence Imaging of Traumatic Brain Injury in a Cryolesion Mouse Model by Smith, Bryan A, Xie, Bang-Wen, van Beek, Ermond R, Que, Ivo, Blankevoort, Vicky, Xiao, Shuzhang, Cole, Erin L, Hoehn, Mathias, Kaijzel, Eric L, Löwik, Clemens W. G. M, Smith, Bradley D

“…Traumatic brain injury is characterized by initial tissue damage, which then can lead to secondary processes such as cell death and blood-brain-barrier…”
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Pyridinium-1-yl Bisphosphonates Are Potent Inhibitors of Farnesyl Diphosphate Synthase and Bone Resorption by Sanders, John M, Song, Yongcheng, Chan, Julian M. W, Zhang, Yonghui, Jennings, Samuel, Kosztowski, Thomas, Odeh, Sarah, Flessner, Ryan, Schwerdtfeger, Christine, Kotsikorou, Evangelia, Meints, Gary A, Gómez, Aurora Ortiz, González-Pacanowska, Dolores, Raker, Amy M, Wang, Hong, van Beek, Ermond R, Papapoulos, Socrates E, Morita, Craig T, Oldfield, Eric

“…We report the design, synthesis and testing of a series of novel bisphosphonates, pyridinium-1-yl-hydroxy-bisphosphonates, based on the results of comparative…”
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Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: The role of the retinoic acid receptor by van Beek, Ermond, Löwik, Clemens, Karperien, Marcel, Papapoulos, Socrates

“…Geranylgeranyl pyrophosphate (GGPP) and geranylgeraniol (GGOH) are used for the prenylation of GTP binding proteins and can reverse the antiresorptive action…”
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Structural requirements for bisphosphonate actions in vitro by van Beek, Ermond, Hoekstra, Monique, van De Ruit, Marjan, Löwik, Clemens, Papapoulos, Socrates

“…We investigated the structural requirements for the binding of bisphosphonates to bone mineral and the relation between their affinity for bone and their…”
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Identification of differentially expressed genes in a renal cell carcinoma tumor model after endostatin-treatment by van Wijngaarden, Jens, Rooij, Karien de, van Beek, Ermond, Bernsen, Hans, Que, Ivo, van Hinsbergh, Victor W M, Löwik, Clemens

“…Endostatin is a cleavage product of collagen XVIII that has shown to inhibit tumor-angiogenesis in experimental tumor models. At present, the exact molecular…”
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Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation by Zhang, Yonghui, Cao, Rong, Yin, Fenglin, Hudock, Michael P., Guo, Rey-Ting, Krysiak, Kilannin, Mukherjee, Sujoy, Gao, Yi-Gui, Robinson, Howard, Song, Yongcheng, No, Joo Hwan, Bergan, Kyle, Leon, Annette, Cass, Lauren, Goddard, Amanda, Chang, Ting-Kai, Lin, Fu-Yang, Van Beek, Ermond, Papapoulos, Socrates, Wang, Andrew H.-J., Kubo, Tadahiko, Ochi, Mitsuo, Mukkamala, Dushyant, Oldfield, Eric

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Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo by van Beek, E, Pieterman, E, Cohen, L, Löwik, C, Papapoulos, S

“…Bisphosphonates, synthetic compounds which suppress bone resorption, are used in the treatment of skeletal disorders. Their mode of action and intracellular…”
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Celecoxib enhances doxorubicin-induced cytotoxicity in MDA-MB231 cells by NF-κB-mediated increase of intracellular doxorubicin accumulation by van Wijngaarden, Jens, van Beek, Ermond, van Rossum, Gerda, van der Bent, Chris, Hoekman, Klaas, van der Pluijm, Gabri, van der Pol, Marjolein A, Broxterman, Henk J, van Hinsbergh, Victor W.M, Löwik, Clemens W.G.M

“…Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) and cyclo-oxygenase (COX) inhibitors are anti-inflammatory agents that have also shown to be useful in…”
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Bisphosphonates inhibit the adhesion of breast cancer cells to bone matrices in vitro by van der Pluijm, G, Vloedgraven, H, van Beek, E, van der Wee-Pals, L, Löwik, C, Papapoulos, S

“…Bisphosphonates are used with increasing frequency in the management of skeletal complications in patients with breast cancer. In this paper, we have…”
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An in vitro model that can distinguish between effects on angiogenesis and on established vasculature: Actions of TNP-470, marimastat and the tubulin-binding agent Ang-510 by van Wijngaarden, Jens, Snoeks, Thomas J.A., van Beek, Ermond, Bloys, Henny, Kaijzel, Eric L., van Hinsbergh, Victor W.M., Löwik, Clemens W.G.M.

“…In anti-cancer therapy, current investigations explore the possibility of two different strategies to target tumor vasculature; one aims at interfering with…”
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