Search Results - "Beeh, KM"

Allergen-Induced Asthmatic Responses Modified by a GATA3-Specific DNAzyme by Krug, Norbert, Hohlfeld, Jens M, Kirsten, Anne-Marie, Kornmann, Oliver, Beeh, Kai M, Kappeler, Dominik, Korn, Stephanie, Ignatenko, Stanislav, Timmer, Wolfgang, Rogon, Cordelia, Zeitvogel, Jana, Zhang, Nan, Bille, Joachim, Homburg, Ursula, Turowska, Agnieszka, Bachert, Claus, Werfel, Thomas, Buhl, Roland, Renz, Jonas, Garn, Holger, Renz, Harald

“…GATA3 is thought to be a critical checkpoint in allergic diathesis. In this study, a synthetic DNAzyme that catalyzes the inactivation of GATA3 when…”
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Benefits of omalizumab as add‐on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE by Humbert, M., Beasley, R., Ayres, J., Slavin, R., Hébert, J., Bousquet, J., Beeh, K.‐M., Ramos, S., Canonica, G. W., Hedgecock, S., Fox, H., Blogg, M., Surrey, K.

“…Background:  Patients with severe persistent asthma who are inadequately controlled despite Global Initiative for Asthma (GINA) 2002 step 4 therapy are a…”
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Real-World Effectiveness of Fluticasone Furoate/Umeclidinium/Vilanterol Once-Daily Single-Inhaler Triple Therapy for Symptomatic COPD: The ELLITHE Non-Interventional Trial by Beeh, Kai-Michael, Scheithe, Karl, Schmutzler, Heike, Krüger, Saskia

“…Real-life effectiveness data on once-daily single-inhaler triple therapy (odSITT) with the inhaled corticosteroid fluticasone furoate (FF), the long-acting…”
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Once-daily NVA237 improves exercise tolerance from the first dose in patients with COPD: the GLOW3 trial by Beeh, Kai M, Singh, Dave, Di Scala, Lilla, Drollmann, Anton

“…Exercise limitation, dynamic hyperinflation, and exertional dyspnea are key features of symptomatic chronic obstructive pulmonary disease (COPD). We assessed…”
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Evaluation of Adherence and Persistence to Triple Therapy in Patients with COPD: A German Claims Data Study by Vogelmeier, Claus F, Beeh, Kai-Michael, Schultze, Michael, Kossack, Nils, Richter, Lena M, Claussen, Jing, Compton, Chris, Noorduyn, Stephen G, Ismaila, Afisi S, Requena, Gema

“…Triple therapy (long-acting muscarinic antagonist/long-acting β -agonist/inhaled corticosteroid) is recommended for patients with chronic obstructive pulmonary…”
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ACTIVATE: the effect of aclidinium/formoterol on hyperinflation, exercise capacity, and physical activity in patients with COPD by Watz, Henrik, Troosters, Thierry, Beeh, Kai M, Garcia-Aymerich, Judith, Paggiaro, Pierluigi, Molins, Eduard, Notari, Massimo, Zapata, Antonio, Jarreta, Diana, Garcia Gil, Esther

“…The Phase IV, 8-week, randomized, double-blind, placebo-controlled ACTIVATE study (NCT02424344) evaluated the effect of aclidinium/formoterol (AB/FF) 400/12 μg…”
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Characteristics of Users and New Initiators of Single- and Multiple-Inhaler Triple Therapy for Chronic Obstructive Pulmonary Disease in Germany by Beeh, Kai-Michael, Rothnie, Kieran J, Claussen, Jing, Hardtstock, Fränce, Knapp, Rachel K, Wilke, Thomas, Czira, Alexandrosz, Compton, Chris, Ismaila, Afisi S

“…To assess patient characteristics of users and new initiators of triple therapy for chronic obstructive pulmonary disease (COPD) in Germany. Retrospective…”
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Comparison of Dry-Powder Inhaler and Pressurized Metered-Dose Inhaler Formulations of Extrafine Beclomethasone Dipropionate/Formoterol Fumarate/Glycopyrronium in Patients with COPD: The TRI-D Randomized Controlled Trial by Beeh, Kai-Michael, Kuna, Piotr, Corradi, Massimo, Viaud, Isabelle, Guasconi, Alessandro, Georges, George

“…Three 52-week studies in COPD have assessed the efficacy and safety of single-inhaler extrafine formulation triple therapy combining beclomethasone…”
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Cost-Effectiveness of Single- versus Multiple-Inhaler Triple Therapy in a UK COPD Population: The INTREPID Trial by Halpin, David MG, Kendall, Robyn, Shukla, Soham, Martin, Alan, Shah, Dhvani, Midwinter, Dawn, Beeh, Kai M, Kocks, Janwillem WH, Jones, Paul W, Compton, Chris, Risebrough, Nancy A, Ismaila, Afisi S

“…Purpose: The 24-week INTREPID trial demonstrated the clinical benefits of once-daily single-inhaler triple therapy (SITT) with fluticasone furoate,…”
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Staging small cell lung cancer: Veterans Administration Lung Study Group versus International Association for the Study of Lung Cancer—what limits limited disease? by Micke, Patrick, Faldum, Andreas, Metz, Tsegay, Beeh, Kai-Michael, Bittinger, Fernando, Hengstler, Jan-Georg, Buhl, Roland

“…Small cell lung cancer (SCLC) is usually classified into a two-stage system, limited (LD) and extensive disease (ED). However, the criteria for these two…”
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The lung function profile of once-daily tiotropium and olodaterol via Respimat® is superior to that of twice-daily salmeterol and fluticasone propionate viaAccuhaler® (ENERGITO® study) by Beeh KM, Derom E, Echave-Sustaeta J, Grönke L, Hamilton A, Zhai D, Bjermer L

“…Kai-Michael Beeh,1 Eric Derom,2 José Echave-Sustaeta,3 Lars Grönke,4 Alan Hamilton,5 Dongmei Zhai,6 Leif Bjermer71Insaf GmbH Institut für Atemwegsforschung,…”
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Randomised controlled trial of montelukast plus inhaled budesonide versus double dose inhaled budesonide in adult patients with asthma by Price, D B, Hernandez, D, Magyar, P, Fiterman, J, Beeh, K M, James, I G, Konstantopoulos, S, Rojas, R, van Noord, J A, Pons, M, Gilles, L, Leff, J A

“…Background: Inhaled corticosteroids (ICS) affect many inflammatory pathways in asthma but have little impact on cysteinyl leukotrienes. This may partly explain…”
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Sputum matrix metalloproteinase-9, tissue inhibitor of metalloprotinease-1, and their molar ratio in patients with chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and healthy subjects by BEEH, K.M., BEIER, J., KORNMANN, O., BUHL, R.

“…Background: Matrix-metalloproteinases (MMPs) and their inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), are involved in the turnover of…”
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Indacaterol acetate/mometasone furoate provides sustained improvements in lung function compared with salmeterol xinafoate/fluticasone propionate in patients with moderate-to-very-severe COPD: results from a Phase II randomized, double-blind 12-week study by Beeh, Kai Michael, Kirsten, Anne-Marie, Tanase, Ana-Maria, Richard, Alexia, Cao, Weihua, Hederer, Bettina, Beier, Jutta, Kornmann, Oliver, van Zyl-Smit, Richard N

“…Fixed-dose combinations of a long-acting beta agonist and an inhaled corticosteroid are more effective than the individual components in COPD. The primary…”
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Effect of ELOM-080 on exacerbations and symptoms in COPD patients with a chronic bronchitis phenotype - a post-hoc analysis of a randomized, double-blind, placebo-controlled clinical trial by Beeh, Kai-Michael, Beier, Jutta, Candler, Henning, Wittig, Thomas

“…Treating symptoms and preventing exacerbations are key components of chronic obstructive pulmonary disease (COPD) long-term management. Recently, a more…”
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Early bronchodilator action of glycopyrronium versus tiotropium in moderate-to-severe COPD patients: a cross-over blinded randomized study (Symptoms and Pulmonary function in the moRnING) by Marin JM, Beeh KM, Clemens A, Castellani W, Schaper L, Saralaya D, Gunstone A, Casamor R, Kostikas K, Aalamian-Mattheis M

“…Jose M Marin,1 Kai M Beeh,2 Andreas Clemens,3 Walter Castellani,4 Lennart Schaper,5 Dinesh Saralaya,6 Anthony Gunstone,7 Ricard Casamor,8 Konstantinos…”
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Dose-response of an extrafine dry powder inhaler formulation of glycopyrronium bromide: randomized, double-blind, placebo-controlled, dose-ranging study (GlycoNEXT) by Beeh, Kai M, Emirova, Aida, Prunier, Hélène, Santoro, Debora, Nandeuil, Marie Anna

“…An extrafine formulation of the long-acting muscarinic antagonist, glycopyrronium bromide (GB), has been developed for delivery via the NEXThaler dry powder…”
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Antiinflammatory properties of ambroxol by Beeh, K M, Beier, J, Esperester, A, Paul, L D

“…Ambroxol is frequently used as mucolytic agent in respiratory diseases associated with increased mucus production like acute or chronic bronchitis. Further,…”
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Elevation of total serum immunoglobulin E is associated with asthma in nonallergic individuals by Beeh, KM, Ksoll, M, Buhl, R

“…Elevated serum immunoglobulin (Ig)E is the hallmark of atopy, and contributes to asthma and bronchial hyperresponsiveness in atopic individuals. In contrast,…”
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Characterization of c-kit Expression in Small Cell Lung Cancer: Prognostic and Therapeutic Implications by MICKE, Patrick, BASRAI, Maryam, HENGSTLER, Jan Georg, FALDUM, Andreas, BITTINGER, Fernando, RÖNNSTRAND, Lars, BLAUKAT, Andree, BEEH, Kai Michael, OESCH, Franz, FISCHER, Berthold, BUHL, Roland

“…Purpose: The tyrosine-kinase receptor c-kit and its ligand stem cell factor are coexpressed in many small cell lung cancer (SCLC) cell lines, leading to the…”
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