Search Results - "Beedle, Amy E. M."

The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening by Andreu, Ion, Falcones, Bryan, Hurst, Sebastian, Chahare, Nimesh, Quiroga, Xarxa, Le Roux, Anabel-Lise, Kechagia, Zanetta, Beedle, Amy E. M., Elosegui-Artola, Alberto, Trepat, Xavier, Farré, Ramon, Betz, Timo, Almendros, Isaac, Roca-Cusachs, Pere

“…Cell response to force regulates essential processes in health and disease. However, the fundamental mechanical variables that cells sense and respond to…”
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In search of a softer environment by Beedle, Amy E. M., Roca-Cusachs, Pere

“…By maximizing cell–substrate force transmission, cancer cells can migrate towards either stiffer or softer substrate regions…”
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Mechanical force application to the nucleus regulates nucleocytoplasmic transport by Andreu, Ion, Granero-Moya, Ignasi, Chahare, Nimesh R., Clein, Kessem, Molina-Jordán, Marc, Beedle, Amy E. M., Elosegui-Artola, Alberto, Abenza, Juan F., Rossetti, Leone, Trepat, Xavier, Raveh, Barak, Roca-Cusachs, Pere

“…Mechanical force controls fundamental cellular processes in health and disease, and increasing evidence shows that the nucleus both experiences and senses…”
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The laminin–keratin link shields the nucleus from mechanical deformation and signalling by Kechagia, Zanetta, Sáez, Pablo, Gómez-González, Manuel, Canales, Brenda, Viswanadha, Srivatsava, Zamarbide, Martín, Andreu, Ion, Koorman, Thijs, Beedle, Amy E. M., Elosegui-Artola, Alberto, Derksen, Patrick W. B., Trepat, Xavier, Arroyo, Marino, Roca-Cusachs, Pere

“…The mechanical properties of the extracellular matrix dictate tissue behaviour. In epithelial tissues, laminin is a very abundant extracellular matrix…”
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Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding by Beedle, Amy E. M., Lynham, Steven, Garcia-Manyes, Sergi

“…The post-translational modification S-sulfenylation functions as a key sensor of oxidative stress. Yet the dynamics of sulfenic acid in proteins remains…”
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Molecular Fluctuations as a Ruler of Force-Induced Protein Conformations by Stannard, Andrew, Mora, Marc, Beedle, Amy E. M, Castro-López, Marta, Board, Stephanie, Garcia-Manyes, Sergi

“…Molecular fluctuations directly reflect the underlying energy landscape. Variance analysis examines protein dynamics in several biochemistry-driven approaches,…”
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Forcing the reversibility of a mechanochemical reaction by Beedle, Amy E. M., Mora, Marc, Davis, Colin T., Snijders, Ambrosius P., Stirnemann, Guillaume, Garcia-Manyes, Sergi

“…Mechanical force modifies the free-energy surface of chemical reactions, often enabling thermodynamically unfavoured reaction pathways. Most of our molecular…”
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The mechanochemistry of copper reports on the directionality of unfolding in model cupredoxin proteins by Beedle, Amy E. M., Lezamiz, Ainhoa, Stirnemann, Guillaume, Garcia-Manyes, Sergi

“…Understanding the directionality and sequence of protein unfolding is crucial to elucidate the underlying folding free energy landscape. An extra layer of…”
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Tailoring protein nanomechanics with chemical reactivity by Beedle, Amy E. M., Mora, Marc, Lynham, Steven, Stirnemann, Guillaume, Garcia-Manyes, Sergi

“…The nanomechanical properties of elastomeric proteins determine the elasticity of a variety of tissues. A widespread natural tactic to regulate protein…”
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The Nanomechanics of Lipid Multibilayer Stacks Exhibits Complex Dynamics by Relat‐Goberna, Josep, Beedle, Amy E. M., Garcia‐Manyes, Sergi

“…The nanomechanics of lipid membranes regulates a large number of cellular functions. However, the molecular mechanisms underlying the plastic rupture of…”
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Mechanobiology—chemical origin of membrane mechanical resistance and force-dependent signaling by Beedle, Amy EM, Williams, Aisling, Relat-Goberna, Josep, Garcia-Manyes, Sergi

“…•We discuss the role of membranes in mechanotransduction.•The chemical composition of lipid membranes directly affects its nanomechanical properties.•We…”
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Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores by Elosegui-Artola, Alberto, Andreu, Ion, Beedle, Amy E.M., Lezamiz, Ainhoa, Uroz, Marina, Kosmalska, Anita J., Oria, Roger, Kechagia, Jenny Z., Rico-Lastres, Palma, Le Roux, Anabel-Lise, Shanahan, Catherine M., Trepat, Xavier, Navajas, Daniel, Garcia-Manyes, Sergi, Roca-Cusachs, Pere

“…YAP is a mechanosensitive transcriptional activator with a critical role in cancer, regeneration, and organ size control. Here, we show that force applied to…”
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Steering chemical reactions with force by Garcia-Manyes, Sergi, Beedle, Amy E. M.

“…Chemical reactivity underlies our fundamental understanding of many physical and biological phenomena. Chemical reactions are typically initiated by heat,…”
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The mechanical stability of proteins regulates their translocation rate into the cell nucleus by Infante, Elvira, Stannard, Andrew, Board, Stephanie J., Rico-Lastres, Palma, Rostkova, Elena, Beedle, Amy E. M., Lezamiz, Ainhoa, Wang, Yong Jian, Gulaidi Breen, Samuel, Panagaki, Fani, Sundar Rajan, Vinoth, Shanahan, Catherine, Roca-Cusachs, Pere, Garcia-Manyes, Sergi

“…A cell’s ability to react to mechanical stimuli is known to be affected by the transport of transcription factors, the proteins responsible for regulating…”
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The role of single-protein elasticity in mechanobiology by Beedle, Amy E. M., Garcia-Manyes, Sergi

“…In addition to biochemical signals and genetic considerations, mechanical forces are rapidly emerging as a master regulator of human physiology. However, the…”
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Single-molecule Force Spectroscopy Predicts a Misfolded, Domain-swapped Conformation in human γD-Crystallin Protein by Garcia-Manyes, Sergi, Giganti, David, Badilla, Carmen L., Lezamiz, Ainhoa, Perales-Calvo, Judit, Beedle, Amy E.M., Fernández, Julio M.

“…Cataract is a protein misfolding disease where the size of the aggregate is directly related to the severity of the disorder. However, the molecular mechanisms…”
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Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection by Pernigo, Stefano, Fukuzawa, Atsushi, Beedle, Amy E.M., Holt, Mark, Round, Adam, Pandini, Alessandro, Garcia-Manyes, Sergi, Gautel, Mathias, Steiner, Roberto A.

“…The sarcomeric cytoskeleton is a network of modular proteins that integrate mechanical and signaling roles. Obscurin, or its homolog obscurin-like-1, bridges…”
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The reversibility of cellular mechano-activation by Beedle, Amy EM, Roca-Cusachs, Pere

“…The cellular microenvironment is highly heterogeneous and dynamic. Therefore, cells must be equipped with molecular tools to adapt and respond to constantly…”
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