Search Results - "Beech, N"

Reconstitution of an N-AChR from Brugia malayi, an evolved change in acetylcholine receptor accessory protein requirements in filarial parasites by Noonan, Jennifer D, Beech, Robin N

“…Neurotransmission is an important target for anthelmintic drugs, where receptor characteristics and response can be examined through reconstitution ex vivo in…”
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Deciphering the molecular determinants of cholinergic anthelmintic sensitivity in nematodes: When novel functional validation approaches highlight major differences between the model Caenorhabditis elegans and parasitic species by Blanchard, Alexandra, Guégnard, Fabrice, Charvet, Claude L, Crisford, Anna, Courtot, Elise, Sauvé, Christine, Harmache, Abdallah, Duguet, Thomas, O'Connor, Vincent, Castagnone-Sereno, Philippe, Reaves, Barbara, Wolstenholme, Adrian J, Beech, Robin N, Holden-Dye, Lindy, Neveu, Cedric

“…Cholinergic agonists such as levamisole and pyrantel are widely used as anthelmintics to treat parasitic nematode infestations. These drugs elicit spastic…”
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Dental management of patients irradiated for head and neck cancer by Beech, N, Robinson, S, Porceddu, S, Batstone, M

“…Patients undergoing radiation therapy as either primary, adjuvant, combination therapy or palliative management of head and neck malignancies are prone to a…”
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Traumatic maxillofacial and brain injuries: a systematic review by Goh, E.Z., Beech, N., Johnson, N.R.

“…Concomitant traumatic brain injury (TBI) and maxillofacial fractures carry the risk of significant morbidity and mortality. The aim of this review was to…”
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Response to the Letter to the Editor: Re: “Outcomes of osseointegrated implants in patients with benign and malignant pathologies of the head and neck: a 10-year single-centre study” by Khadembaschi, D., Borgna, S.C., Beech, N., Batstone, M.D.

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Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions by Kotze, Andrew C., Hunt, Peter W., Skuce, Philip, von Samson-Himmelstjerna, Georg, Martin, Richard J., Sager, Heinz, Krücken, Jürgen, Hodgkinson, Jane, Lespine, Anne, Jex, Aaron R., Gilleard, John S., Beech, Robin N., Wolstenholme, Adrian J., Demeler, Janina, Robertson, Alan P., Charvet, Claude L., Neveu, Cedric, Kaminsky, Ronald, Rufener, Lucien, Alberich, Melanie, Menez, Cecile, Prichard, Roger K.

“…•We report on the Consortium for Anthelmintic Resistance and Susceptibility 2013 meeting.•Recent advances in the identification of markers for anthelmintic…”
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Intraoperative computed tomography for orbital reconstruction: a systematic review by Goh, Elizabeth Z., Bullis, Sam, Beech, Nicholas, Johnson, Nigel R.

“…Orbital reconstruction is a common procedure with inherent challenges and important consequences. Intraoperative use of computed tomography (CT) is an emerging…”
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E‐scooters and maxillofacial fractures: a seven‐year multi‐centre retrospective review by Goh, EZ, Beech, N, Johnson, NR

“…ABSTRACT Background Standing electric scooters (e‐scooters) are a cost‐effective and environmentally‐friendly transport alternative, but also elicit…”
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Outcomes of osseointegrated implants in patients with benign and malignant pathologies of the head and neck: a 10-year single-centre study by Khadembaschi, D., Borgna, S.C., Beech, N., Batstone, M.D.

“…The surgical management of head and neck pathologies involving the maxilla and mandible results in significant functional and aesthetic deficits, and…”
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Structural mechanism underlying the differential effects of ivermectin and moxidectin on the C. elegans glutamate-gated chloride channel GLC-2 by Kaji, Mark D., Noonan, Jennifer D., Geary, Timothy G., Beech, Robin N.

“…Nematode glutamate-gated chloride channels (GluCls) are targets of ivermectin (IVM) and moxidectin (MOX), structurally dissimilar macrocyclic lactone (ML)…”
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Functional Characterization of a Novel Class of Morantel-Sensitive Acetylcholine Receptors in Nematodes by Courtot, Elise, Charvet, Claude L, Beech, Robin N, Harmache, Abdallah, Wolstenholme, Adrian J, Holden-Dye, Lindy, O'Connor, Vincent, Peineau, Nicolas, Woods, Debra J, Neveu, Cedric

“…Acetylcholine receptors are pentameric ligand-gated channels involved in excitatory neuro-transmission in both vertebrates and invertebrates. In nematodes,…”
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Population genetics of anthelmintic resistance in parasitic nematodes by Gilleard, J S, Beech, R N

“…A key aim of anthelmintic resistance research is to identify molecular markers that could form the basis of sensitive and accurate diagnostic tests. These…”
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A Functional Comparison of Homopentameric Nicotinic Acetylcholine Receptors (ACR-16) Receptors From Necator americanus and Ancylostoma ceylanicum by Kaji, Mark D, Geary, Timothy G, Beech, Robin N

“…Effective control of hookworm infections in humans and animals relies on using a small group of anthelmintics. Many of these drugs target cholinergic…”
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Molecular cloning and characterization of novel glutamate-gated chloride channel subunits from Schistosoma mansoni by Dufour, Vanessa, Beech, Robin N, Wever, Claudia, Dent, Joseph A, Geary, Timothy G

“…Cys-loop ligand-gated ion channels (LGICs) mediate fast ionotropic neurotransmission. They are proven drug targets in nematodes and arthropods, but are poorly…”
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genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery by Laing, Roz, Kikuchi, Taisei, Martinelli, Axel, Tsai, Isheng J, Beech, Robin N, Redman, Elizabeth, Holroyd, Nancy, Bartley, David J, Beasley, Helen, Britton, Collette, Curran, David, Devaney, Eileen, Gilabert, Aude, Hunt, Martin, Jackson, Frank, Johnston, Stephanie L, Kryukov, Ivan, Li, Keyu, Morrison, Alison A, Reid, Adam J, Sargison, Neil, Saunders, Gary I, Wasmuth, James D, Wolstenholme, Adrian, Berriman, Matthew, Gilleard, John S, Cotton, James A

“…BACKGROUND: The small ruminant parasite Haemonchus contortus is the most widely used parasitic nematode in drug discovery, vaccine development and anthelmintic…”
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Characterization of a vacuolar importer of secologanin in Catharanthus roseus by Li, Fanfan, Shahsavarani, Mohammadamin, Handy-Hart, Cody-Jordan, Côté, Audrey, Brasseur-Trottier, Xavier, Montgomery, Victoria, Beech, Robin N., Liu, Lan, Bayen, Stéphane, Qu, Yang, De Luca, Vincenzo, Dastmalchi, Mehran

“…Monoterpenoid indole alkaloid (MIA) biosynthesis in Catharanthus roseus is a paragon of the spatiotemporal complexity achievable by plant specialized…”
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Anthelmintic resistance: markers for resistance, or susceptibility? by Beech, R N, Skuce, P, Bartley, D J, Martin, R J, Prichard, R K, Gilleard, J S

“…The Consortium for Anthelmintic Resistance and Susceptibility (CARS) brings together researchers worldwide, with a focus of advancing knowledge of resistance…”
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Haemonchus contortus P-glycoproteins interact with host eosinophil granules: a novel insight into the role of ABC transporters in host-parasite interaction by Issouf, Mohamed, Guégnard, Fabrice, Koch, Christine, Le Vern, Yves, Blanchard-Letort, Alexandra, Che, Hua, Beech, Robin N, Kerboeuf, Dominique, Neveu, Cedric

“…Eosinophils are one of the major mammalian effector cells encountered by helminths during infection. In the present study, we investigated the effects of…”
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Recent Duplication and Functional Divergence in Parasitic Nematode Levamisole-Sensitive Acetylcholine Receptors by Duguet, Thomas B, Charvet, Claude L, Forrester, Sean G, Wever, Claudia M, Dent, Joseph A, Neveu, Cedric, Beech, Robin N

“…Helminth parasites rely on fast-synaptic transmission in their neuromusculature to experience the outside world and respond to it. Acetylcholine plays a…”
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Pre-radiotherapy dental extractions and osteoradionecrosis by Beech, N, Porceddu, S, Batstone, M

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