Search Results - "Bedwell, Amanda A."

Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer's disease by Jullienne, Amandine, Szu, Jenny I, Quan, Ryan, Trinh, Michelle V, Norouzi, Tannoz, Noarbe, Brenda P, Bedwell, Amanda A, Eldridge, Kierra, Persohn, Scott C, Territo, Paul R, Obenaus, Andre

“…The 5xFAD mouse is a popular model of familial Alzheimer's disease (AD) that is characterized by early beta-amyloid (Aβ) deposition and cognitive decrements…”
Get full text

Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice by Oblak, Adrian L., Kotredes, Kevin P., Pandey, Ravi S., Reagan, Alaina M., Ingraham, Cynthia, Perkins, Bridget, Lloyd, Christopher, Baker, Deborah, Lin, Peter B., Soni, Disha M., Tsai, Andy P., Persohn, Scott A., Bedwell, Amanda A., Eldridge, Kierra, Speedy, Rachael, Meyer, Jill A., Peters, Johnathan S., Figueiredo, Lucas L., Sasner, Michael, Territo, Paul R., Sukoff Rizzo, Stacey J., Carter, Gregory W., Lamb, Bruce T., Howell, Gareth R.

“…Obesity is recognized as a significant risk factor for Alzheimer’s disease (AD). Studies have supported the notion that obesity accelerates AD-related…”
Get full text

Prophylactic evaluation of verubecestat on disease‐ and symptom‐modifying effects in 5XFAD mice by Oblak, Adrian L., Cope, Zackary A., Quinney, Sara K., Pandey, Ravi S., Biesdorf, Carla, Masters, Andi R., Onos, Kristen D., Haynes, Leslie, Keezer, Kelly J., Meyer, Jill A., Peters, Jonathan S., Persohn, Scott A., Bedwell, Amanda A., Eldridge, Kierra, Speedy, Rachael, Little, Gabriela, Williams, Sean‐Paul, Noarbe, Brenda, Obenaus, Andre, Sasner, Michael, Howell, Gareth R., Carter, Gregory W., Williams, Harriet, Lamb, Bruce T., Territo, Paul R., Sukoff Rizzo, Stacey J.

“…Introduction Alzheimer's disease (AD) is the most common form of dementia. Beta‐secretase (BACE) inhibitors have been proposed as potential therapeutic…”
Get full text

Pharmacokinetic, pharmacodynamic, and transcriptomic analysis of chronic levetiracetam treatment in 5XFAD mice: A MODEL‐AD preclinical testing core study by Onos, Kristen D., Quinney, Sara K., Jones, David R., Masters, Andrea R., Pandey, Ravi, Keezer, Kelly J., Biesdorf, Carla, Metzger, Ingrid F., Meyers, Jill A., Peters, Johnathon, Persohn, Scott C., McCarthy, Brian P., Bedwell, Amanda A., Figueiredo, Lucas L., Cope, Zackary A., Sasner, Michael, Howell, Gareth R., Williams, Harriet M., Oblak, Adrian L., Lamb, Bruce T., Carter, Gregory W., Rizzo, Stacey J. Sukoff, Territo, Paul R.

“…Introduction Hyperexcitability and epileptiform activity are commonplace in Alzheimer's disease (AD) patients and associated with impaired cognitive function…”
Get full text

The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice by Reagan, Alaina M, Christensen, Karen E, Graham, Leah C, Bedwell, Amanda A, Eldridge, Kierra, Speedy, Rachael, Figueiredo, Lucas L, Persohn, Scott C, Bottiglieri, Teodoro, Nho, Kwangsik, Sasner, Michael, Territo, Paul R, Rozen, Rima, Howell, Gareth R

“…Vascular contributions to cognitive impairment and dementia (VCID) particularly Alzheimer’s disease and related dementias (ADRDs) are increasing; however,…”
Get full text

Evaluation of chronic lead effects in the blood brain barrier system by DCE-CT by Gu, Huiying, Territo, Paul R., Persohn, Scott A., Bedwell, Amanda A., Eldridge, Kierra, Speedy, Rachael, Chen, Zhe, Zheng, Wei, Du, Yansheng

“…Lead (Pb) is an environmental factor has been suspected of contributing to the dementia including Alzheimer’s disease (AD). Our previous studies have shown…”
Get full text

Subcutaneous nerve stimulation for rate control in ambulatory dogs with persistent atrial fibrillation by Yuan, Yuan, Liu, Xiao, Wan, Juyi, Wong, Johnson, Bedwell, Amanda A., Persohn, Scott A., Shen, Changyu, Fishbein, Michael C., Chen, Lan S., Chen, Zhenhui, Everett, Thomas H., Territo, Paul R., Chen, Peng-Sheng

“…Subcutaneous nerve stimulation (ScNS) damages the stellate ganglion and improves rhythm control of atrial fibrillation (AF) in ambulatory dogs. The purpose of…”
Get full text

Pharmacodynamics Assessment of Aducanumab in 5XFAD mice: A MODEL‐AD PTC Study by Territo, Paul R, Quinney, Sara K, Masters, Andrea R, Haynes, Katy A, Cope, Zackery A, Little, Gabriela, Williams, Sean‐Paul, Meyer, Jill A, Peters, Jonathan, Figueiredo, Lucas, Persohn, Scott C, Bedwell, Amanda A, Eldridge, Kierra, Speedy, Rachael, Seyfried, Nicholas T., Onos, Kristen D, Sasner, Michael, Howell, Gareth R, Carter, Gregory W, Oblak, Adrian L, Lamb, Bruce T, Rizzo, Stacey J Sukoff

“…Background The Preclinical Testing Core (PTC) of the Model Organism Development for Evaluation of Late Onset Alzheimer’s Disease (MODEL‐AD) consortium…”
Get full text

Application of neurovascular uncoupling and whole brain network connectomics to assess the role of genetic and dietary risk factors in the LOAD2 mouse model by Silvola, Rebecca, Persohn, Scott C, Oblak, Adrian L, Lamb, Bruce T, Bedwell, Amanda A, Eldridge, Kierra, Speedy, Rachael, Howell, Gareth R, Sasner, Michael, Territo, Paul R

“…Background As research efforts to discover and develop promising future therapeutics continues, the necessity to develop clinically significant Alzheimer’s…”
Get full text

Lifespan diffusion MRI reveals structural abnormalities in the 5xFAD model of Alzheimer’s Disease by Noarbe, Brenda P, Jullienne, Amandine, Silvola, Rebecca, Bedwell, Amanda A, Eldridge, Kierra, Speedy, Rachael, Persohn, Scott C, Territo, Paul R, Obenaus, Andre, AD, MODEL

“…Background The Model Organism Development and Evaluation for Late‐Onset Alzheimer’s Disease (MODEL‐AD) Consortium has been established to develop the next…”
Get full text

Metabolic and Cerebrovascular Perturbations in the 5xFAD Mouse Model of Alzheimer’s Disease by Jullienne, Amandine, Szu, Jenny, Quan, Ryan, Silvola, Rebecca, Bedwell, Amanda A, Eldridge, Kierra, Speedy, Rachael, Persohn, Scott C, Obenaus, Andre, Territo, Paul R

“…Background The Model Organism Development and Evaluation for Late‐Onset Alzheimer’s Disease (MODEL‐AD) Consortium seeks to develop the next generation of AD…”
Get full text

Characterization of brain metabolism, volume, and vasculature of the 5xFAD mouse model of Alzheimer’s Disease across lifespan by Jullienne, Amandine, Szu, Jenny, Quan, Ryan, Trinh, Michelle V, Norouzi, Tannoz, Noarbe, Brenda P, Silvola, Rebecca, Bedwell, Amanda A, Eldridge, Kierra, Speedy, Rachael, Persohn, Scott C, Territo, Paul R, Obenaus, Andre

“…Background The MODEL‐AD Consortium seeks to develop the next generation of Alzheimer’s Disease models based on human data. A popular model of familial AD is…”
Get full text

Characterization of brain metabolism, volume, and vasculature of the 5xFAD mouse model of Alzheimer’s Disease across lifespan by Jullienne, Amandine, Szu, Jenny, Quan, Ryan, Trinh, Michelle V, Norouzi, Tannoz, Noarbe, Brenda P, Silvola, Rebecca, Bedwell, Amanda A, Eldridge, Kierra, Speedy, Rachael, Persohn, Scott C, Territo, Paul R, Obenaus, Andre

“…Background The MODEL‐AD Consortium seeks to develop the next generation of Alzheimer’s Disease models based on human data. A popular model of familial AD is…”
Get full text

Assessing the Role of PLCG2M28L Risk In A Novel Mouse Model Late‐Onset Alzheimer’s Disease by Territo, Paul R, Oblak, Adrian L, Persohn, Scott C, Bedwell, Amanda A, Eldridge, Kierra, Kotredes, Kevin P, Pandey, Ravi S, Rizzo, Stacey J Sukoff, Carter, Gregory W, Sasner, Michael, Howell, Gareth R, Lamb, Bruce T

“…Background MODEL‐AD has developed and characterized novel mouse models that aim to better phenocopy human LOAD for preclinical testing. More than 40 different…”
Get full text

Cerebral perfusion and glucose metabolism profiling reveal special phenotypes in the hAPOE3, hAPOE4, Trem2 risk, and doubled risks mice by Lin, Peter Bor‐Chian, Persohn, Scott C, Bedwell, Amanda A, Jiang, Lei, Eldridge, Kierra, Speedy, Rachael, Kotredes, Kevin P, Pandey, Ravi S, Williams, Harriet M, Oblak, Adrian L, Sasner, Michael, Howell, Gareth R, Carter, Gregory W, Lamb, Bruce T, Territo, Paul R

“…Background Alzheimer’s disease (AD) is the most common cause of dementia in the United States. Approximately 95% of patients have sporadic Late‐Onset AD (LOAD)…”
Get full text

Neurovascular uncoupling of cerebral blood flow and glucose metabolism in APOE4, TREM2, and APOE4.TREM2 mice by Territo, Paul R., Lin, Peter B., Persohn, Scott C., Bedwell, Amanda A., Eldridge, Kierra, Speedy, Rachael, Kotredes, Kevin P., Pandey, Ravi S., Oblak, Adrian L., Sasner, Michael, Carter, Gregory W., Lamb, Bruce T., Howell, Gareth

“…Background Alzheimer’s disease (AD) is the most common cause of dementia in the United States, with approximately 95% of patients exhibiting sporadic…”
Get full text

Neurovascular uncoupling of cerebral blood flow and glucose metabolism in APOE4, TREM2, and APOE4.TREM2 mice: Development of new models and analysis methods/novel assays and technologies by Territo, Paul R., Lin, Peter B., Persohn, Scott C., Bedwell, Amanda A., Eldridge, Kierra, Speedy, Rachael, Kotredes, Kevin P., Pandey, Ravi S., Oblak, Adrian L., Sasner, Michael, Carter, Gregory W., Lamb, Bruce T., Howell, Gareth

“…Abstract Background Alzheimer’s disease (AD) is the most common cause of dementia in the United States, with approximately 95% of patients exhibiting sporadic…”
Get full text

Pharmacokinetic, pharmacodynamic and transcriptomic analyses of verubecestat treatment in 5XFAD mice: Development of new models and analysis methods/novel assays and technologies by Territo, Paul R., Quinney, Sara K., Biesdorf, Carla, Masters, Andrea R., Onos, Kristen, Haynes, Leslie, Keezer, Kelly, Cope, Zackery A., Meyer, Jill A., Peters, Jonathan, Persohn, Scott C., Figueiredo, Lucas, Bedwell, Amanda A., Eldridge, Kierra, Speedy, Rachael, Sasner, Michael, Howell, Gareth, Carter, Gregory W., Oblak, Adrian L., Lamb, Bruce T., Rizzo, Stacey J. Sukoff

“…Abstract Background The Preclinical Testing Core (PTC) of the Model Organism Development for Late Onset Alzheimer’s Disease (MODEL‐AD) consortium established a…”
Get full text

Pharmacokinetic, pharmacodynamic and transcriptomic analyses of verubecestat treatment in 5XFAD mice by Territo, Paul R., Quinney, Sara K., Biesdorf, Carla, Masters, Andrea R., Onos, Kristen, Haynes, Leslie, Keezer, Kelly, Cope, Zackery A., Meyer, Jill A., Peters, Jonathan, Persohn, Scott C., Figueiredo, Lucas, Bedwell, Amanda A., Eldridge, Kierra, Speedy, Rachael, Sasner, Michael, Howell, Gareth, Carter, Gregory W., Oblak, Adrian L., Lamb, Bruce T., Rizzo, Stacey J. Sukoff

“…Background The Preclinical Testing Core (PTC) of the Model Organism Development for Late Onset Alzheimer’s Disease (MODEL‐AD) consortium established a…”
Get full text

Plcg2 M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer's Disease-Relevant Phenotypes in Mice by Oblak, Adrian L, Kotredes, Kevin P, Pandey, Ravi S, Reagan, Alaina M, Ingraham, Cynthia, Perkins, Bridget, Lloyd, Christopher, Baker, Deborah, Lin, Peter B, Soni, Disha M, Tsai, Andy P, Persohn, Scott A, Bedwell, Amanda A, Eldridge, Kierra, Speedy, Rachael, Meyer, Jill A, Peters, Johnathan S, Figueiredo, Lucas L, Sasner, Michael, Territo, Paul R, Sukoff Rizzo, Stacey J, Carter, Gregory W, Lamb, Bruce T, Howell, Gareth R

“…Obesity is recognized as a significant risk factor for Alzheimer's disease (AD). Studies have supported the notion that obesity accelerates AD-related…”
Get full text