Search Results - "Bedoui, Sammy"

Emerging connectivity of programmed cell death pathways and its physiological implications by Bedoui, Sammy, Herold, Marco J., Strasser, Andreas

“…The removal of functionally dispensable, infected or potentially neoplastic cells is driven by programmed cell death (PCD) pathways, highlighting their…”
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STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury by Abdullah, Amar, Zhang, Moses, Frugier, Tony, Bedoui, Sammy, Taylor, Juliet M, Crack, Peter J

“…Traumatic brain injury (TBI) represents a major cause of disability and death worldwide with sustained neuroinflammation and autophagy dysfunction contributing…”
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Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production by White, Michael J., McArthur, Kate, Metcalf, Donald, Lane, Rachael M., Cambier, John C., Herold, Marco J., van Delft, Mark F., Bedoui, Sammy, Lessene, Guillaume, Ritchie, Matthew E., Huang, David C.S., Kile, Benjamin T.

“…Activated caspases are a hallmark of apoptosis induced by the intrinsic pathway, but they are dispensable for cell death and the apoptotic clearance of cells…”
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NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5 by Baker, Paul J., Boucher, Dave, Bierschenk, Damien, Tebartz, Christina, Whitney, Paul G., D'Silva, Damian B., Tanzer, Maria C., Monteleone, Mercedes, Robertson, Avril A. B., Cooper, Matthew A., Alvarez‐Diaz, Silvia, Herold, Marco J., Bedoui, Sammy, Schroder, Kate, Masters, Seth L.

“…Humans encode two inflammatory caspases that detect cytoplasmic LPS, caspase‐4 and caspase‐5. When activated, these trigger pyroptotic cell death and…”
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Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection by Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.

“…Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during…”
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Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation by Collins, Nicholas, Jiang, Xiaodong, Zaid, Ali, Macleod, Bethany L., Li, Jane, Park, Chang Ook, Haque, Ashraful, Bedoui, Sammy, Heath, William R., Mueller, Scott N., Kupper, Thomas S., Gebhardt, Thomas, Carbone, Francis R.

“…Although memory T cells within barrier tissues can persist as permanent residents, at least some exchange with blood. The extent to which this occurs is…”
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IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid by Naujoks, Jan, Tabeling, Christoph, Dill, Brian D, Hoffmann, Christine, Brown, Andrew S, Kunze, Mareike, Kempa, Stefan, Peter, Andrea, Mollenkopf, Hans-Joachim, Dorhoi, Anca, Kershaw, Olivia, Gruber, Achim D, Sander, Leif E, Witzenrath, Martin, Herold, Susanne, Nerlich, Andreas, Hocke, Andreas C, van Driel, Ian, Suttorp, Norbert, Bedoui, Sammy, Hilbi, Hubert, Trost, Matthias, Opitz, Bastian

“…Macrophages can be niches for bacterial pathogens or antibacterial effector cells depending on the pathogen and signals from the immune system. Here we show…”
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Cross-presentation of viral and self antigens by skin-derived CD103 + dendritic cells by Brooks, Andrew G, Caminschi, Irina, Shortman, Ken, Carbone, Francis R, Wojtasiak, Magdalena, Allan, Rhys S, Bedoui, Sammy, Waithman, Jason, Wakim, Linda, Heath, William R, Whitney, Paul G, Eidsmo, Liv

“…The functions of individual dendritic cell subsets in the skin are unclear. Heath and colleagues now show that langerin-positive CD103 + dermal dendritic cells…”
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Caspase-2 does not play a critical role in cell death induction and bacterial clearance during Salmonella infection by Engel, Sven, Doerflinger, Marcel, Lee, Ariane R., Strasser, Andreas, Herold, Marco J., Bedoui, Sammy, Bachem, Annabell

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Cellular requirements for systemic control of Salmonella enterica serovar Typhimurium infections in mice by Kupz, Andreas, Bedoui, Sammy, Strugnell, Richard A

“…The rational design of vaccines requires an understanding of the contributions of individual immune cell subsets to immunity. With this understanding, targeted…”
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Microbial Metabolites in the Maturation and Activation of Dendritic Cells and Their Relevance for Respiratory Immunity by Wilson, Kayla R., Gressier, Elise, McConville, Malcolm J., Bedoui, Sammy

“…The respiratory tract is a gateway for viruses and bacteria from the external environment to invade the human body. Critical to the protection against these…”
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GPR41 and GPR43 regulate CD8 + T cell priming during herpes simplex virus type 1 infection by Lee, Ariane Renita, Wilson, Kayla Roberta, Clarke, Michele, Engel, Sven, Tscharke, David C, Gebhardt, Thomas, Bedoui, Sammy, Bachem, Annabell

“…Naïve CD8 T cells need to undergo a complex and coordinated differentiation program to gain the capacity to control virus infections. This not only involves…”
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Classical Type 1 Dendritic Cells Dominate Priming of Th1 Responses to Herpes Simplex Virus Type 1 Skin Infection by Harpur, Christopher M, Kato, Yu, Dewi, Shinta T, Stankovic, Sanda, Johnson, Darryl N, Bedoui, Sammy, Whitney, Paul G, Lahoud, Mireille H, Caminschi, Irina, Heath, William R, Brooks, Andrew G, Gebhardt, Thomas

“…CD4 T cell responses are crucial for the control of many intracellular pathogens, yet the requirements for their induction are not fully understood. To better…”
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In vivo IFN-γ secretion by NK cells in response to Salmonella typhimurium requires NLRC4 inflammasomes by Kupz, Andreas, Curtiss, 3rd, Roy, Bedoui, Sammy, Strugnell, Richard A

“…Natural killer (NK) cells are a critical part of the innate immune defense against viral infections and for the control of tumors. Much less is known about how…”
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Sympathetic nerves control bacterial clearance by Lankadeva, Yugeesh R., May, Clive N., McKinley, Michael J., Neeland, Melanie R., Ma, Shuai, Hocking, Dianna M., Robins-Browne, Roy, Bedoui, Sammy, Farmer, David G. S., Bailey, Simon R., Martelli, Davide, McAllen, Robin M.

“…A neural reflex mediated by the splanchnic sympathetic nerves regulates systemic inflammation in negative feedback fashion, but its consequences for host…”
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Contribution of Thy1⁺ NK cells to protective IFN-γ production during Salmonella Typhimurium infections by Kupz, Andreas, Scott, Timothy A., Belz, Gabrielle T., Andrews, Daniel M., Greyer, Marie, Lew, Andrew M., Brooks, Andrew G., Smyth, Mark J., Curtiss, Roy, Bedoui, Sammy, Strugnell, Richard A.

“…IFN-γ is critical for immunity against infections with intracellular pathogens, such as Salmonella enterica . However, which of the many cell types capable of…”
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CD4+ T cell immunity to Salmonella is transient in the circulation by Peres, Newton G, Wang, Nancy, Whitney, Paul, Engel, Sven, Shreenivas, Meghanashree M, Comerford, Ian, Hocking, Dianna M, Erazo, Anna B, Förster, Irmgard, Kupz, Andreas, Gebhardt, Thomas, McColl, Shaun R, McSorley, Stephen J, Bedoui, Sammy, Strugnell, Richard A

“…While Salmonella enterica is seen as an archetypal facultative intracellular bacterial pathogen where protection is mediated by CD4+ T cells, identifying…”
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Cooperation between Monocyte-Derived Cells and Lymphoid Cells in the Acute Response to a Bacterial Lung Pathogen by Brown, Andrew S, Yang, Chao, Fung, Ka Yee, Bachem, Annabell, Bourges, Dorothée, Bedoui, Sammy, Hartland, Elizabeth L, van Driel, Ian R

“…Legionella pneumophila is the causative agent of Legionnaires' disease, a potentially fatal lung infection. Alveolar macrophages support intracellular…”
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Nuclear response to divergent mitochondrial DNA genotypes modulates the interferon immune response by Lopez Sanchez, M. Isabel G, Ziemann, Mark, Bachem, Annabell, Makam, Rahul, Crowston, Jonathan G, Pinkert, Carl A, McKenzie, Matthew, Bedoui, Sammy, Trounce, Ian A, Bai, Yidong, Shukla, Deepak

“…Mitochondrial OXPHOS generates most of the energy required for cellular function. OXPHOS biogenesis requires the coordinated expression of the nuclear and…”
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T Cell Help Amplifies Innate Signals in CD8+ DCs for Optimal CD8+ T Cell Priming by Greyer, Marie, Whitney, Paul G., Stock, Angus T., Davey, Gayle M., Tebartz, Christina, Bachem, Annabell, Mintern, Justine D., Strugnell, Richard A., Turner, Stephen J., Gebhardt, Thomas, O’Keeffe, Meredith, Heath, William R., Bedoui, Sammy

“…DCs often require stimulation from CD4+ T cells to propagate CD8+ T cell responses, but precisely how T cell help optimizes the priming capacity of DCs and why…”
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