Search Results - "Bednarz, S"

N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent by Misra, Raj N, Xiao, Hai-yun, Kim, Kyoung S, Lu, Songfeng, Han, Wen-Ching, Barbosa, Stephanie A, Hunt, John T, Rawlins, David B, Shan, Weifang, Ahmed, Syed Z, Qian, Ligang, Chen, Bang-Chi, Zhao, Rulin, Bednarz, Mark S, Kellar, Kristen A, Mulheron, Janet G, Batorsky, Roberta, Roongta, Urvashi, Kamath, Amrita, Marathe, Punit, Ranadive, Sunanda A, Sack, John S, Tokarski, John S, Pavletich, Nikola P, Lee, Francis Y. F, Webster, Kevin R, Kimball, S. David

“…N-Acyl-2-aminothiazoles with nonaromatic acyl side chains containing a basic amine were found to be potent, selective inhibitors of CDK2/cycE which exhibit…”
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LARGE AREA HYDROLOGIC MODELING AND ASSESSMENT PART II: MODEL APPLICATION by Srinivasan, R., Ramanarayanan, T. S., Arnold, J. G., Bednarz, S. T.

“…This paper describes the application of a river basin scale hydrologic model (described in Part I) to Richland and Chambers Creeks watershed (RC watershed) in…”
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A new facile method for the synthesis of 1-arylimidazole-5-carboxylates by Chen, Bang-Chi, Bednarz, Mark S, Zhao, Rulin, Sundeen, Joseph E, Chen, Ping, Shen, Zhongqi, Skoumbourdis, Amanda P, Barrish, Joel C

“…A new facile method for the preparation of 1-arylimidazole-5-carboxylates was developed. The new method involved reaction of anilines and ethyl glyoxylate in…”
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Experimental and bioinformatic approach to identifying antigenic epitopes in human α- and β-enolases by Pietkiewicz, Jadwiga, Danielewicz, Regina, Bednarz-Misa, Iwona S, Ceremuga, Ireneusz, Wiśniewski, Jerzy, Mierzchala-Pasierb, Magdalena, Bronowicka-Szydełko, Agnieszka, Ziomek, Edmund, Gamian, Andrzej

“…Human α- and β-enolases are highly homologous enzymes, difficult to differentiate immunologically. In this work, we describe production, purification and…”
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Microwave-assisted oxidation of alcohols using Magtrieve by Bogdal, D, Lukasiewicz, M, Pielichowski, J, Miciak, A, Bednarz, Sz

“…Primary and secondary alcohols can be selectively oxidized under microwave irradiation into the corresponding aldehydes and ketones within 5–30 min using…”
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Novel triethylsilane mediated reductive N -alkylation of amines: improved synthesis of 1-(4-imidazolyl)methyl-4-sulfonylbenzodiazepines, new farnesyltransferase inhibitors by Chen, Bang-Chi, Sundeen, Joseph E, Guo, Peng, Bednarz, Mark S, Zhao, Rulin

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Receiver clock-based integrity monitoring for GPS precision approaches by Bednarz, S., Misra, P.

“…The errors in the vertical position and clock bias estimates obtained from GPS pseudo-range measurements are highly correlated. Therefore, the error in a…”
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Microwave-Assisted Epoxidation of Simple Alkenes in the Presence of Hydrogen Peroxide by Bogdal, D., Lukasiewicz, M., Pielichowski, J., Bednarz, S.

“…A novel application of microwave irradiation for the epoxidation of some simple alkenes, in which hydrogen peroxide was used as an oxidant together with sodium…”
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Geography Education: The Glass Is Half Full and It's Getting Fuller by Bednarz, Robert S., Bednarz, Sarah Witham

“…This article examines the recent progress of geography education as an academic subfield of geography and as an area of activity in K-12 education. Challenges…”
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Process Development of Sotagliflozin, a Dual Inhibitor of Sodium–Glucose Cotransporter-1/2 for the Treatment of Diabetes by Zhao, Matthew M, Zhang, Haiming, Iimura, Shinya, Bednarz, Mark S, Song, Qiu-Ling, Lim, Ngiap-Kie, Yan, Jie, Wu, Wenxue, Dai, Kuangchu, Gu, Xiaodong, Wang, Youchu

“…The development of an efficient manufacturing process for sotagliflozin (LX4211), a dual inhibitor of sodium–glucose cotransporter-1/2 (SGLT-1/2) for the…”
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Dual Metalloprotease Inhibitors:  Mercaptoacetyl-Based Fused Heterocyclic Dipeptide Mimetics as Inhibitors of Angiotensin-Converting Enzyme and Neutral Endopeptidase by Robl, Jeffrey A, Sun, Chong-Qing, Stevenson, Jay, Ryono, Denis E, Simpkins, Ligaya M, Cimarusti, Maria P, Dejneka, Tamara, Slusarchyk, William A, Chao, Sam, Stratton, Leslie, Misra, Raj N, Bednarz, Mark S, Asaad, Magdi M, Cheung, Hong Son, Abboa-Offei, Benoni E, Smith, Patricia L, Mathers, Parker D, Fox, Maxine, Schaeffer, Thomas R, Seymour, Andrea A, Trippodo, Nick C

“…A series of 7,6- and 7,5-fused bicyclic thiazepinones and oxazepinones were generated and incorporated as conformationally restricted dipeptide surrogates in…”
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Environmental Research and Education in US Geography by Bednarz, Robert S.

“…This article evaluates geography as an appropriate home for environmental education. First, it argues that many geographers have defined geography as a…”
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Process Development of Tryptophan Hydroxylase Inhibitor LX1031, a Drug Candidate for the Treatment of Irritable Bowel Syndrome by Zhao, Matthew M, Zhang, Haiming, Iimura, Shinya, Bednarz, Mark S, Kanamarlapudi, Ramanaiah C, Yan, Jie, Lim, Ngiap-Kie, Wu, Wenxue

“…Two process routes for LX1031, a tryptophan hydroxylase inhibitor for the treatment of irritable bowel syndrome, were developed. They shared the same left-hand…”
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One-Pot Synthesis of 4‑Substituted 3‑Amino-2-cyanothiophenes Involving O‑Ethyl Thioformate by Zhang, Haiming, Bednarz, Mark S., Lim, Ngiap-Kie, Hernandez, Gonzalo, Wu, Wenxue

“…An efficient one-pot synthesis of 4-substituted 3-amino-2-cyanothiophenes is described. Treatment of 2-alkyl or aryl substituted acetonitrile sequentially with…”
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Brave New World: Citizenship in Geospatially Enriched Environments by Bednarz, Sarah Witham, Bednarz, Robert S.

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A New Strategy for the Construction of the Imidazo[1,5-a]quinoxalin-4-one Ring System and Its Application to the Efficient Synthesis of BMS-238497, a Novel and Potent Lck Inhibitor by Chen, Bang-Chi, Zhao, Rulin, Bednarz, Mark S, Wang, Bei, Sundeen, Joseph E, Barrish, Joel C

“…A new efficient strategy was developed for the construction of the imidazo[1,5-a]quinoxalin-4-one ring system. The new method involves condensation of…”
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A New Efficient Synthesis of 5-Aryloxazoles from Arylidene Diacetates and Application to the Preparation of BMS-337197, a Novel IMPDH Inhibitor by Chen, Bang-Chi, S. Bednarz, Mark, Zhang, Huiping, Zhao, Rulin, G. Murali Dhar, T., Balasubramanian, Balu, C. Barrish, Joel

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A Modified Approach to 2-(N-Aryl)-1,3-oxazoles:  Application to the Synthesis of the IMPDH Inhibitor BMS-337197 and Analogues by Dhar, T. G. Murali, Guo, Junqing, Shen, Zhongqi, Pitts, William J, Gu, Henry H, Chen, Bang-Chi, Zhao, Rulin, Bednarz, Mark S, Iwanowicz, Edwin J

“…A modified approach to the synthesis of 2-(N-aryl)-1,3-oxazoles, employing an optimized iminophosphorane/heterocumulene-mediated methodology, and its…”
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Discovery of N-[2-[2-[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a Novel and Potent Inhibitor of Inosine Monophosphate Dehydrogenase with Excellent in Vivo Activity by Dhar, T. G. Murali, Shen, Zhongqi, Guo, Junqing, Liu, Chunjian, Watterson, Scott H, Gu, Henry H, Pitts, William J, Fleener, Catherine A, Rouleau, Katherine A, Sherbina, N. Z, McIntyre, Kim W, Witmer, Mark R, Tredup, Jeffrey A, Chen, Bang-Chi, Zhao, Rulin, Bednarz, Mark S, Cheney, Daniel L, MacMaster, John F, Miller, Laura M, Berry, Karen K, Harper, Timothy W, Barrish, Joel C, Hollenbaugh, Diane L, Iwanowicz, Edwin J

“…Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme that is involved in the de novo synthesis of purine nucleotides. Novel 2-aminooxazoles were…”
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Gender Differences in Mobility Adaptations of Senior Citizens: A Case Study of Yao City, Japan by Yoshikawa, Aya, Bednarz, Robert S.

“…This study investigates the factors influencing seniors' travel behaviors. One-hundred-ninety-three community-dwelling seniors in a Japanese city participated…”
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