Search Results - "Bednarz, M S"

Dual Metalloprotease Inhibitors:  Mercaptoacetyl-Based Fused Heterocyclic Dipeptide Mimetics as Inhibitors of Angiotensin-Converting Enzyme and Neutral Endopeptidase by Robl, Jeffrey A, Sun, Chong-Qing, Stevenson, Jay, Ryono, Denis E, Simpkins, Ligaya M, Cimarusti, Maria P, Dejneka, Tamara, Slusarchyk, William A, Chao, Sam, Stratton, Leslie, Misra, Raj N, Bednarz, Mark S, Asaad, Magdi M, Cheung, Hong Son, Abboa-Offei, Benoni E, Smith, Patricia L, Mathers, Parker D, Fox, Maxine, Schaeffer, Thomas R, Seymour, Andrea A, Trippodo, Nick C

“…A series of 7,6- and 7,5-fused bicyclic thiazepinones and oxazepinones were generated and incorporated as conformationally restricted dipeptide surrogates in…”
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BMS-196085 : A potent and selective full agonist of the human β3 adrenergic receptor by GAVAI, A. V, SHER, P. M, WANG, T. C, SUN, C. Q, SLUSARCHYK, D. A, SKWISH, S, ALLEN, G. T, HILLYER, D. E, FROHLICH, B. H, ABBOA-OFFEI, B. E, CAP, M, WALDRON, T. L, MIKKILINENI, A. B, GEORGE, R. J, TESFAMARIAM, B, HARPER, T. W, CIOSEK, C. P, YOUNG, D. A, DICKINSON, K. E, SEYMOUR, A. A, ARBEENY, C. M, WASHBURN, W. N, POSS, K. M, MCCANN, P. J, GIROTRA, R. N, FISHER, L. G, WU, G, BEDNARZ, M. S, MATHUR, A

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BMS-196085: a potent and selective full agonist of the human beta(3) adrenergic receptor by Gavai, A V, Sher, P M, Mikkilineni, A B, Poss, K M, McCann, P J, Girotra, R N, Fisher, L G, Wu, G, Bednarz, M S, Mathur, A, Wang, T C, Sun, C Q, Slusarchyk, D A, Skwish, S, Allen, G T, Hillyer, D E, Frohlich, B H, Abboa-Offei, B E, Cap, M, Waldron, T L, George, R J, Tesfamariam, B, Harper, T W, Ciosek, Jr, C P, Young, D A, Dickinson, K E, Seymour, A A, Arbeeny, C M, Washburn, W N

“…A series of 4-hydroxy-3-methylsulfonanilido-1,2-diarylethylamines were prepared and evaluated for their human beta(3) adrenergic receptor agonist activity. SAR…”
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Synthesis of deuterium-labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation of the drug and its metabolites in human serum by Chen, Bang-Chi, Sundeen, Joseph E., Guo, Peng, Bednarz, Mark S., Hangeland, Jon J., Ahmed, Syed Z., Jemal, Mohammed

“…D5‐labeled isotopomers of atorvastatin, atorvastatin lactone and its hydroxy metabolites were synthesized as internal standards for use in a LC/MS/MS method…”
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A new facile method for the synthesis of 1-arylimidazole-5-carboxylates by Chen, Bang-Chi, Bednarz, Mark S, Zhao, Rulin, Sundeen, Joseph E, Chen, Ping, Shen, Zhongqi, Skoumbourdis, Amanda P, Barrish, Joel C

“…A new facile method for the preparation of 1-arylimidazole-5-carboxylates was developed. The new method involved reaction of anilines and ethyl glyoxylate in…”
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Novel triethylsilane mediated reductive N -alkylation of amines: improved synthesis of 1-(4-imidazolyl)methyl-4-sulfonylbenzodiazepines, new farnesyltransferase inhibitors by Chen, Bang-Chi, Sundeen, Joseph E, Guo, Peng, Bednarz, Mark S, Zhao, Rulin

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A New Strategy for the Construction of the Imidazo[1,5-a]quinoxalin-4-one Ring System and Its Application to the Efficient Synthesis of BMS-238497, a Novel and Potent Lck Inhibitor by Chen, Bang-Chi, Zhao, Rulin, Bednarz, Mark S, Wang, Bei, Sundeen, Joseph E, Barrish, Joel C

“…A new efficient strategy was developed for the construction of the imidazo[1,5-a]quinoxalin-4-one ring system. The new method involves condensation of…”
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Reaction of quinoxalin-2-ones with TosMIC reagent: synthesis of imidazo[1,5- a]quinoxalin-4-ones by Chen, Ping, Barrish, Joel C., Iwanowicz, Edwin, Lin, James, Bednarz, Mark S., Chen, Bang-Chi

“…Imidazo[1,5- a]quinoxalin-4-ones were prepared in four steps starting from 1,2-phenylenediamines using a new strategy for the construction of the ring system…”
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A Modified Approach to 2-(N-Aryl)-1,3-oxazoles:  Application to the Synthesis of the IMPDH Inhibitor BMS-337197 and Analogues by Dhar, T. G. Murali, Guo, Junqing, Shen, Zhongqi, Pitts, William J, Gu, Henry H, Chen, Bang-Chi, Zhao, Rulin, Bednarz, Mark S, Iwanowicz, Edwin J

“…A modified approach to the synthesis of 2-(N-aryl)-1,3-oxazoles, employing an optimized iminophosphorane/heterocumulene-mediated methodology, and its…”
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Discovery of N-[2-[2-[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a Novel and Potent Inhibitor of Inosine Monophosphate Dehydrogenase with Excellent in Vivo Activity by Dhar, T. G. Murali, Shen, Zhongqi, Guo, Junqing, Liu, Chunjian, Watterson, Scott H, Gu, Henry H, Pitts, William J, Fleener, Catherine A, Rouleau, Katherine A, Sherbina, N. Z, McIntyre, Kim W, Witmer, Mark R, Tredup, Jeffrey A, Chen, Bang-Chi, Zhao, Rulin, Bednarz, Mark S, Cheney, Daniel L, MacMaster, John F, Miller, Laura M, Berry, Karen K, Harper, Timothy W, Barrish, Joel C, Hollenbaugh, Diane L, Iwanowicz, Edwin J

“…Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme that is involved in the de novo synthesis of purine nucleotides. Novel 2-aminooxazoles were…”
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Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase by Pitts, William J., Guo, Junqing, Dhar, T.G.Murali, Shen, Zhongqi, Gu, Henry H., Watterson, Scott H., Bednarz, Mark S., Chen, Bang-Chi, Barrish, Joel C., Bassolino, Donna, Cheney, Daniel, Fleener, Catherine A., Rouleau, Katherine A., Hollenbaugh, Diane L., Iwanowicz, Edwin J.

“…A series of novel triazine-based small molecule inhibitors (IV) of inosine monophosphate dehydrogenase was prepared. The synthesis and the structure–activity…”
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AN IMPROVED LARGE SCALE SYNTHESIS OF 2,3-DIHYDROXYTEREPHTHALIC ACID AND DIMETHYL 2,3-DIHYDROXYTEREPHTHLATE by Chen, B.-C., Bednarz, M. S., Sundeen, J. E., Zhang, Z. J., Caulfield, T. J., Bisacchi, G. S.

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Dual metalloprotease inhibitors: Mercaptoacetyl-based fused heterocyclic dipeptide kinetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase by ROBL, J. A, SUN, C.-Q, MISRA, R. N, BEDNARZ, M. S, ASAAD, M. M, CHEUNG, H. S, ABBOA-OFFEI, B. E, SMITH, P. L, MATHERS, P. D, FOX, M, SCHAEFFER, T. R, SEYMOUR, A. A, STEVENSON, J, TRIPPODO, N. C, RYONO, D. E, SIMPKINS, L. M, CIMARUSTI, M. P, DEJNEKA, T, SLUSARCHYK, W. A, CHAO, S, STRATTON, L

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A Facile Method for the Transformation of N-(tert-Butoxycarbonyl) α-Amino Acids to N-Unprotected α-Amino Methyl Esters by Chen, Bang-Chi, Skoumbourdis, Amanda P, Guo, Peng, Bednarz, Mark S, Kocy, Octavian R, Sundeen, Joseph E, Vite, Gregory D

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A New Efficient Synthesis of 5-Aryloxazoles from Arylidene Diacetates and Application to the Preparation of BMS-337197, a Novel IMPDH Inhibitor by Chen, Bang-Chi, S. Bednarz, Mark, Zhang, Huiping, Zhao, Rulin, G. Murali Dhar, T., Balasubramanian, Balu, C. Barrish, Joel

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Discovery of N-[2-[2-[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4-morpholineacetamide as a Novel and Potent Inhibitor of Inosine Monophosphate Dehydrogenase (IMPDH) with Excellent in Vivo Activity by Murali Dhar, T. G, Shen, Zhongqi, Guo, Junqing, Liu, Chunjian, Watterson, Scott H, Gu, Henry H, Pitts, William J, Fleener, Catherine A, Rouleau, Katherine A, Sherbina, N. Z, McIntyre, Kim W, Shuster, David J, Witmer, Mark R, Tredup, Jeffrey A, Chen, Bang-Chi, Zhao, Rulin, Bednarz, Mark S, Cheney, Daniel L, MacMaster, John F, Miller, Laura M, Berry, Karen K, Harper, Timothy W, Barrish, Joel C, Hollenbaugh, Diane L, Iwanowicz, Edwin J

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A new highly enantioselective synthesis of both ( R)- and ( S)-2-mercaptosuccinic acids by Chen, Bang-Chi, Bednarz, Mark S, Kocy, Octavian R, Sundeen, Joseph E

“…( R)- and ( S)-2-Mercaptosuccinic acids 4 were prepared in five steps in >96% ee and 49–52% overall yield via a new efficient synthesis starting from…”
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Addition of Benzylic and Allylic Organozinc and Grignard Reagents to Resin-Bound Imines To Provide α-Branched Secondary Amines Bearing a Wide Variety of Functional Groups. Utility in the Synthesis of β-3 Adrenergic Receptor Agonists by Wu, Gang, Cai, Zhen-Wei, Bednarz, Mark S, Kocy, Octavian R, Gavai, Ashvinikumar V, Godfrey, Jollie D, Washburn, William N, Poss, Michael A, Sher, Philip M

“…Benzylic and allylic organozinc and Grignard reagents have been added to resin-bound imines to provide α-branched secondary amines. Many functional groups,…”
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