Search Results - "Bednarova, Klara"

Clustered abasic lesions profoundly change the structure and stability of human telomeric G-quadruplexes by Kejnovská, Iva, Bednárová, Klára, Renciuk, Daniel, Dvoráková, Zuzana, Školáková, Petra, Trantírek, Lukáš, Fiala, Radovan, Vorlícková, Michaela, Sagi, Janos

“…Ionizing radiation produces clustered damage to DNA which is difficult to repair and thus more harmful than single lesions. Clustered lesions have only been…”
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Guanine quadruplexes in the RNA genome of the tick-borne encephalitis virus: their role as a new antiviral target and in virus biology by Holoubek, Jiří, Bednářová, Klára, Haviernik, Jan, Huvarová, Ivana, Dvořáková, Zuzana, Černý, Jiří, Outlá, Martina, Salát, Jiří, Konkol'ová, Eva, Boura, Evzen, Růžek, Daniel, Vorlíčková, Michaela, Eyer, Luděk, Renčiuk, Daniel

“…We have identified seven putative guanine quadruplexes (G4) in the RNA genome of tick-borne encephalitis virus (TBEV), a flavivirus causing thousands of human…”
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Antiviral activity of porphyrins and porphyrin-like compounds against tick-borne encephalitis virus: Blockage of the viral entry/fusion machinery by photosensitization-mediated destruction of the viral envelope by Holoubek, Jiří, Salát, Jiří, Kotouček, Jan, Kastl, Tomáš, Vancová, Marie, Huvarová, Ivana, Bednář, Petr, Bednářová, Klára, Růžek, Daniel, Renčiuk, Daniel, Eyer, Luděk

“…Tick-borne encephalitis virus (TBEV), the causative agent of tick-borne encephalitis (TBE), is a medically important flavivirus endemic to the European-Asian…”
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8‐Oxoguanine in a quadruplex of the human telomere DNA sequence by Vorlícková, Michaela, Tomasko, Martin, Sagi, Andras J., Bednarova, Klara, Sagi, Janos

“…8‐Oxoguanine is a ubiquitous oxidative base lesion. We report here on the effect of this lesion on the structure and stability of quadruplexes formed by the…”
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Unique C. elegans telomeric overhang structures reveal the evolutionarily conserved properties of telomeric DNA by Školáková, Petra, Foldynová-Trantírková, Silvie, Bednářová, Klára, Fiala, Radovan, Vorlíčková, Michaela, Trantírek, Lukáš

“…There are two basic mechanisms that are associated with the maintenance of the telomere length, which endows cancer cells with unlimited proliferative…”
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Quadruplexes of human telomere dG(3)(TTAG(3))(3) sequences containing guanine abasic sites by Skoláková, Petra, Bednárová, Klára, Vorlícková, Michaela, Sagi, Janos

“…This study was performed to evaluate how the loss of a guanine base affects the structure and stability of the three-tetrad G-quadruplex of…”
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Assessing the Anthelmintic Candidates BLK127 and HBK4 for Their Efficacy on Haemonchus contortus Adults and Eggs, and Their Hepatotoxicity and Biotransformation by Zajíčková, Markéta, Prchal, Lukáš, Vokřál, Ivan, Nguyen, Linh Thuy, Kurz, Thomas, Gasser, Robin, Bednářová, Klára, Mičundová, Magdalena, Lungerich, Beate, Michel, Oliver, Skálová, Lenka

“…As a widely distributed parasitic nematode of ruminants, Haemonchus contortus has become resistant to most anthelmintic classes, there has been a major demand…”
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Hexahelicene DNA-binding: Minor groove selectivity, semi-intercalation and chiral recognition by Vacek, Jan, Zatloukalova, Martina, Bartheldyova, Eliska, Reha, David, Minofar, Babak, Bednarova, Klara, Renciuk, Daniel, Coufal, Jan, Fojta, Miroslav, Zadny, Jaroslav, Gessini, Alessandro, Rossi, Barbara, Storch, Jan, Kabelac, Martin

“…In this contribution, we focused on a fundamental study targeting the interaction of water-soluble [6]helicene derivative 1…”
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Circular Dichroism Spectroscopy of DNA: From Duplexes to Quadruplexes by Vorlíčková, Michaela, Kejnovská, Iva, Bednářová, Klára, Renčiuk, Daniel, Kypr, Jaroslav

“…ABSTRACT Nucleic acids bear the genetic information and participate in its expression and evolution during replication, repair, recombination, transcription,…”
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Circular dichroism and guanine quadruplexes by Vorlíčková, Michaela, Kejnovská, Iva, Sagi, Janos, Renčiuk, Daniel, Bednářová, Klára, Motlová, Jitka, Kypr, Jaroslav

“…Circular dichroism (CD) is remarkably sensitive to the conformational states of nucleic acids; therefore, CD spectroscopy has been used to study most features…”
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Systematic investigation of sequence requirements for DNA i-motif formation by Školáková, Petra, Renčiuk, Daniel, Palacký, Jan, Krafčík, Daniel, Dvořáková, Zuzana, Kejnovská, Iva, Bednářová, Klára, Vorlíčková, Michaela

“…Abstract The formation of intercalated motifs (iMs) - secondary DNA structures based on hemiprotonated C.C+ pairs in suitable cytosine-rich DNA sequences, is…”
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i-Motif of cytosine-rich human telomere DNA fragments containing natural base lesions by Dvořáková, Zuzana, Renčiuk, Daniel, Kejnovská, Iva, Školáková, Petra, Bednářová, Klára, Sagi, Janos, Vorlíčková, Michaela

“…Abstract i-Motif (iM) is a four stranded DNA structure formed by cytosine-rich sequences, which are often present in functionally important parts of the genome…”
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Diversity of Parallel Guanine Quadruplexes Induced by Guanine Substitutions by Bednářová, Klára, Vorlíčková, Michaela, Renčiuk, Daniel

“…Recently, we reported an inhibitory effect of guanine substitutions on the conformational switch from antiparallel to parallel quadruplexes (G4) induced by…”
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Guanine Substitutions Prevent Conformational Switch from Antiparallel to Parallel G‐Quadruplex by Bednářová, Klára, Kejnovská, Iva, Vorlíčková, Michaela, Renčiuk, Daniel

“…Guanine quadruplexes, recently reported to form in vivo, represent a broad spectrum of non‐canonical conformations of nucleic acids. The actual conformation…”
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G‐Quadruplex Formation by DNA Sequences Deficient in Guanines: Two Tetrad Parallel Quadruplexes Do Not Fold Intramolecularly by Kejnovská, Iva, Stadlbauer, Petr, Trantírek, Lukáš, Renčiuk, Daniel, Gajarský, Martin, Krafčík, Daniel, Palacký, Jan, Bednářová, Klára, Šponer, Jiří, Mergny, Jean‐Louis, Vorlíčková, Michaela

“…Guanine quadruplexes (G4s) are noncanonical forms of nucleic acids that are frequently found in genomes. The stability of G4s depends, among other factors, on…”
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Loss of loop adenines alters human telomere d[AG3(TTAG3)3] quadruplex folding by Babinský, Martin, Fiala, Radovan, Kejnovská, Iva, Bednářová, Klára, Marek, Radek, Sagi, Janos, Sklenář, Vladimír, Vorlíčková, Michaela

“…Abasic (AP) lesions are the most frequent type of damages occurring in cellular DNA. Here we describe the conformational effects of AP sites substituted for…”
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Ethanol is a better inducer of DNA guanine tetraplexes than potassium cations by Vorlíčková, Michaela, Bednářová, Klára, Kypr, Jaroslav

“…Guanine tetraplexes are a biologically relevant alternative of the Watson and Crick duplex of DNA. It is thought that potassium or other cations present in the…”
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Intramolecular and intermolecular guanine quadruplexes of DNA in aqueous salt and ethanol solutions by Vorlíčková, Michaela, Bednářová, Klára, Kejnovská, Iva, Kypr, Jaroslav

“…DNA guanine quadruplexes are all based on stacks of guanine tetrads, but they can be of many types differing by mutual strand orientation, topology, position…”
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Diverse effects of naturally occurring base lesions on the structure and stability of the human telomere DNA quadruplex by Konvalinová, Helena, Dvořáková, Zuzana, Renčiuk, Daniel, Bednářová, Klára, Kejnovská, Iva, Trantírek, Lukáš, Vorlíčková, Michaela, Sagi, Janos

“…Various base lesions continuously form in cellular nucleic acids and the unrepaired lesions are promutagenic and procarcinogenic. Though natural base lesions…”
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Quadruplexes of human telomere dG3(TTAG3)3 sequences containing guanine abasic sites by Školáková, Petra, Bednářová, Klára, Vorlíčková, Michaela, Sagi, Janos

“…► Loss of a guanine base does not hinder the formation of G-quadruplex of human telomere sequence. ► Each depurination strongly destabilizes the quadruplex of…”
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