Search Results - "Bednar, Filip"

Arginase 1 is a key driver of immune suppression in pancreatic cancer by Menjivar, Rosa E, Nwosu, Zeribe C, Du, Wenting, Donahue, Katelyn L, Hong, Hanna S, Espinoza, Carlos, Brown, Kristee, Velez-Delgado, Ashley, Yan, Wei, Lima, Fatima, Bischoff, Allison, Kadiyala, Padma, Salas-Escabillas, Daniel, Crawford, Howard C, Bednar, Filip, Carpenter, Eileen, Zhang, Yaqing, Halbrook, Christopher J, Lyssiotis, Costas A, Pasca di Magliano, Marina

“…An extensive fibroinflammatory stroma rich in macrophages is a hallmark of pancreatic cancer. In this disease, it is well appreciated that macrophages are…”
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Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice by Collins, Meredith A, Bednar, Filip, Zhang, Yaqing, Brisset, Jean-Christophe, Galbán, Stefanie, Galbán, Craig J, Rakshit, Sabita, Flannagan, Karen S, Adsay, N Volkan, Pasca di Magliano, Marina

“…Pancreatic cancer is almost invariably associated with mutations in the KRAS gene, most commonly KRASG12D, that result in a dominant-active form of the KRAS…”
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Survival Benefit of Adjuvant Chemotherapy After Pancreatoduodenectomy for Ampullary Adenocarcinoma: a Propensity-Matched National Cancer Database (NCDB) Analysis by Kamarajah, Sivesh K., Bednar, Filip, Cho, Clifford S., Nathan, Hari

“…Background The benefit of adjuvant chemotherapy (AC) after pancreatoduodenectomy (PD) for ampullary adenocarcinoma is uncertain. We aimed to evaluate the…”
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Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance by YAQING ZHANG, WEI YAN, COLLINS, Meredith A, BEDNAR, Filip, RAKSHIT, Sabita, ZETTER, Bruce R, STANGER, Ben Z, IVY CHUNG, RHIM, Andrew D, PASCA DI MAGLIANO, Marina

“…Pancreatic cancer, one of the deadliest human malignancies, is almost invariably associated with the presence of an oncogenic form of Kras. Mice expressing…”
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The Notch pathway is important in maintaining the cancer stem cell population in pancreatic cancer by Abel, Ethan V, Kim, Edward J, Wu, Jingjiang, Hynes, Mark, Bednar, Filip, Proctor, Erica, Wang, Lidong, Dziubinski, Michele L, Simeone, Diane M

“…Pancreatic cancer stem cells (CSCs) represent a small subpopulation of pancreatic cancer cells that have the capacity to initiate and propagate tumor…”
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Early Gastric Signet Ring Cell Adenocarcinoma as a Flat Pale Patch on an Esophagogastroduodenoscopy by Takakura, Will, Eswaran, Shanti, Chey, William D, Ueyama, Hiroya, Kwon, Richard, Todisco, Andrea, Owens, Scott, Stoffel, Elena, Crysler, Oxana V, Bednar, Filip, Hart, Benjamin R

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Metastatic pancreatic cancer is dependent on oncogenic Kras in mice by Collins, Meredith A, Brisset, Jean-Christophe, Zhang, Yaqing, Bednar, Filip, Pierre, Josette, Heist, Kevin A, Galbán, Craig J, Galbán, Stefanie, di Magliano, Marina Pasca

“…Pancreatic cancer is one of the deadliest human malignancies, and its prognosis has not improved over the past 40 years. Mouse models that spontaneously…”
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Immunotherapy for pancreatic ductal adenocarcinoma by Carpenter, Eileen, Nelson, Sarah, Bednar, Filip, Cho, Clifford, Nathan, Hari, Sahai, Vaibhav, Magliano, Marina Pasca, Frankel, Timothy L.

“…Pancreatic ductal adenocarcinoma (PDAC) remains a lethal cancer with an urgent need for better medical therapies. Efforts have been made to investigate the…”
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Bmi1 enhances tumorigenicity and cancer stem cell function in pancreatic adenocarcinoma by Proctor, Erica, Waghray, Meghna, Lee, Cheong Jun, Heidt, David G, Yalamanchili, Malica, Li, Chenwei, Bednar, Filip, Simeone, Diane M

“…Bmi1 is an integral component of the Polycomb Repressive Complex 1 (PRC1) and is involved in the pathogenesis of multiple cancers. It also plays a key role in…”
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Analysis of Predictors of Resection and Survival in Locally Advanced Stage III Pancreatic Cancer: Does the Nature of Chemotherapy Regimen Influence Outcomes? by Bednar, Filip, Zenati, Mazen S., Steve, Jennifer, Winters, Sharon, Ocuin, Lee M., Bahary, Nathan, Hogg, Melissa E., Zeh, Herbert J., Zureikat, Amer H.

“…Background Locally advanced unresectable pancreatic cancer (LAPC) historically portends a poor prognosis. FOLFIRINOX and gemcitabine/nab-paclitaxel have proven…”
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Pancreatic cancer stem cell biology and its therapeutic implications by Bednar, Filip, Simeone, Diane M.

“…Pancreatic cancer remains one of the most difficult malignancies to treat. Significant developments in our understanding of pancreatic cancer biology have…”
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Metformin and cancer stem cells: old drug, new targets by Bednar, Filip, Simeone, Diane M

“…In this issue of the journal, Bao and colleagues report (beginning on page 355) that the antidiabetic drug metformin targets pancreatic cancer stem cells…”
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Clinical Utility of Epigenetic Changes in Pancreatic Adenocarcinoma by Thompson, Joyce K, Bednar, Filip

“…Pancreatic cancer is a molecularly heterogeneous disease. Epigenetic changes and epigenetic regulatory mechanisms underlie at least some of this heterogeneity…”
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ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis by Wang, Lidong, Yang, Huibin, Abel, Ethan V, Ney, Gina M, Palmbos, Phillip L, Bednar, Filip, Zhang, Yaqing, Leflein, Jacob, Waghray, Meghna, Owens, Scott, Wilkinson, John E, Prasad, Jayendra, Ljungman, Mats, Rhim, Andrew D, Pasca di Magliano, Marina, Simeone, Diane M

“…The initiation of pancreatic ductal adenocarcinoma (PDA) is linked to activating mutations in KRAS. However, in PDA mouse models, expression of oncogenic…”
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Differential Contribution of Pancreatic Fibroblast Subsets to the Pancreatic Cancer Stroma by Garcia, Paloma E., Adoumie, Maeva, Kim, Esther C., Zhang, Yaqing, Scales, Michael K., El-Tawil, Yara S., Shaikh, Amara Z., Wen, Hui-Ju, Bednar, Filip, Allen, Ben L., Wellik, Deneen M., Crawford, Howard C., Pasca di Magliano, Marina

“…Although the healthy pancreas consists mostly of epithelial cells, pancreatic cancer and the precursor lesions known as pancreatic intraepithelial neoplasia,…”
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S82 Longitudinal Immunoprofiling of Pancreatic Cancer Patients to Identify Mediators of Therapy Resistance by Carpenter, Eileen, Kemp, Samantha, Kadiyala, Padma, Steele, Nina, Elhossiny, Ahmed, Sirihorachai, Veerin, Du, Wenting, Espinoza, Carlos, The, Stephanie, Freeman, Julia, Bhalla, Sean, Singhvi, Ajay, Anderson, Michelle, Kwon, Richard, Wamsteker, Erik-Jan, Prabhu, Anoop, Schulman, Allison, Gunchick, Valerie, Sahai, Vaibhav, Frankel, Timothy, Bednar, Filip, Di Magliano, Marina Pasca

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Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism by Bednar, Filip, Schofield, Heather K, Collins, Meredith A, Yan, Wei, Zhang, Yaqing, Shyam, Nikhil, Eberle, Jaime A, Almada, Luciana L, Olive, Kenneth P, Bardeesy, Nabeel, Fernandez-Zapico, Martin E, Nakada, Daisuke, Simeone, Diane M, Morrison, Sean J, Pasca di Magliano, Marina

“…Epigenetic dysregulation is involved in the initiation and progression of many epithelial cancers. BMI1, a component of the polycomb protein family, plays a…”
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Pancreatic cancer stem cells and relevance to cancer treatments by Bednar, Filip, Simeone, Diane M.

“…Pancreatic cancer continues to be a malignancy with few therapeutic options. The majority of patients that present for an evaluation have locally advanced or…”
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Predictors of Acute and Late Toxicity in Patients Receiving Chemoradiation for Unresectable Pancreatic Cancer by Das, Rishi, Hadley, Scott, Sahai, Vaibhav, Bednar, Filip, Evans, Joseph, Lawrence, Theodore, Cuneo, Kyle, Abbott, Madeline R., Schipper, Matt

“…Patients with pancreatic cancer undergoing chemoradiation therapy may experience acute and chronic side effects. We conducted an exploratory analysis of…”
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Clinical Staging Uncertainty and Treatment Sequencing in Pancreatic Cancer by Bednar, Filip

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