Search Results - "Bednárová, Lucie"
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Enzymatic synthesis of hypermodified DNA polymers for sequence-specific display of four different hydrophobic groups
Published in Nucleic acids research (02-12-2020)“…Abstract A set of modified 2′-deoxyribonucleoside triphosphates (dNTPs) bearing a linear or branched alkane, indole or phenyl group linked through ethynyl or…”
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Effect of TFE on the Helical Content of AK17 and HAL‑1 Peptides: Theoretical Insights into the Mechanism of Helix Stabilization
Published in The journal of physical chemistry. B (18-02-2016)“…Fluorinated alcohols such as 2,2,2-trifluoroethanol (TFE) are among the most frequently used cosolvents in experiment studies of peptides. They have…”
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Synthesis, Chiral Resolution, and Optical Properties of 2,18‐Dihydoxy‐5,10,15‐trioxa[9]helicene
Published in European journal of organic chemistry (08-01-2021)“…Herein, we report a simple and efficient approach to synthesize a functionalized 2,18‐dimethoxy‐5,10,15‐trioxa[9]helicene. It was synthesized from simple…”
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4
Multimerization rules for G-quadruplexes
Published in Nucleic acids research (06-09-2017)“…G-quadruplexes can multimerize under certain conditions, but the sequence requirements of such structures are not well understood. In this study, we…”
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Unveiling the DHX15-G-patch interplay in retroviral RNA packaging
Published in Proceedings of the National Academy of Sciences - PNAS (01-10-2024)“…We explored how a simple retrovirus, Mason-Pfizer monkey virus (M-PMV) to facilitate its replication process, utilizes DHX15, a cellular RNA helicase,…”
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Superanionic DNA: enzymatic synthesis of hypermodified DNA bearing four different anionic substituents at all four nucleobases
Published in Nucleic acids research (27-11-2023)“…Abstract We designed and synthesized a set of four 2′-deoxyribonucleoside 5′-O-triphosphates (dNTPs) derived from 5-substituted pyrimidines and 7-substituted…”
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Sequence Requirements of Intrinsically Fluorescent G‑Quadruplexes
Published in Biochemistry (Easton) (17-07-2018)“…G-Quadruplexes are four-stranded nucleic acid structures typically stabilized by GGGG tetrads. These structures are intrinsically fluorescent, which expands…”
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Contact lenses as a potential vehicle of Candida transmission
Published in Contact lens & anterior eye (01-10-2024)“…Contact lenses can be contaminated with various microorganisms, including pathogenic yeasts of the genus Candida, which are known for their ability to adhere…”
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Altered biochemical specificity of G-quadruplexes with mutated tetrads
Published in Nucleic acids research (15-12-2016)“…A fundamental motif in canonical nucleic acid structure is the base pair. Mutations that disrupt base pairs are typically destabilizing, but stability can…”
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IR Spectra of n-Bu4M (M = Si, Ge, Sn, Pb), n-BuAuPPh3-d15, and "n-Bu" on a Gold Surface
Published in The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory (22-06-2017)“…Observed and DFT-calculated IR spectra of n-Bu4M (M = Si, Ge, Sn, Pb), (CH3CH2CH213CD2)4Sn, and n-BuAuPPh3-d15 are reported and assigned. The asymmetric CH…”
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11
Effect of hydrocarbon stapling on the properties of α-helical antimicrobial peptides isolated from the venom of hymenoptera
Published in Amino acids (01-11-2012)“…The impact of inserting hydrocarbon staples into short α-helical antimicrobial peptides lasioglossin III and melectin (antimicrobial peptides of wild bee…”
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Dynamics of lipid layers with/without bounded antimicrobial peptide halictine-1
Published in Vibrational spectroscopy (01-11-2017)“…[Display omitted] •The system was investigated by ATR-FTIR spectroscopy and analyzed by principal component analysis.•PC/PG lipid multilayers periodically…”
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13
Synthesis of nucleosides and dNTPs bearing oligopyridine ligands linked through an octadiyne tether, their incorporation into DNA and complexation with transition metal cations
Published in Organic & biomolecular chemistry (07-01-2013)“…Modified nucleosides (dA(R)s and dC(R)s) bearing bipyridine or terpyridine ligands attached through an octadiyne linker were prepared by single-step…”
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Aging-Induced Structural Transition of Nanoscale Oleanolic Acid Amphiphiles and Selectivity against Gram-Positive Bacteria
Published in ACS applied nano materials (25-03-2022)“…Triterpenoids are among the largest groups of functional plant secondary metabolites but with intrinsically low water solubility. Because of their rigid…”
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Interaction of a novel antimicrobial peptide isolated from the venom of solitary bee Colletes daviesanus with phospholipid vesicles and Escherichia coli cells
Published in Journal of peptide science (01-11-2014)“…The peptide named codesane (COD), consisting of 18 amino acid residues and isolated from the venom of wild bee Colletes daviesanus (Hymenoptera : Colletidae),…”
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Spectroscopic properties of the nonplanar amide group: A computational study
Published in Chirality (New York, N.Y.) (01-11-2007)“…Experimental studies suggest that amide bond may significantly deviate from planar arrangement even in linear peptides and proteins. In order to find out the…”
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Synthesis of 8-bromo-, 8-methyl- and 8-phenyl-dATP and their polymerase incorporation into DNA
Published in Organic & biomolecular chemistry (21-10-2008)“…dATP derivatives bearing Br, Me or Ph groups in position 8 were prepared and tested as substrates for DNA polymerases to show that 8-Br-dATP and 8-Me-dATP were…”
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Vibrational and electronic optical activity of the chiral disulphide group: Implications for disulphide bridge conformation
Published in Chirality (New York, N.Y.) (15-05-2010)“…Using dihydrogendisulphide (H2S2), dimethyl‐ ((CH3)2S2), and diethyldisulphide ((CH3CH2)2S2)as model molecules, theoretical ECD, VCD, and ROA spectra of…”
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An Ultimate Stereocontrol in Asymmetric Synthesis of Optically Pure Fully Aromatic Helicenes
Published in Journal of the American Chemical Society (08-07-2015)“…The role of the helicity of small molecules in enantioselective catalysis, molecular recognition, self-assembly, material science, biology, and nanoscience is…”
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Helical Bilayer Nanographenes: Impact of the Helicene Length on the Structural, Electrochemical, Photophysical, and Chiroptical Properties
Published in Journal of the American Chemical Society (31-05-2023)“…Helical bilayer nanographenes (HBNGs) are chiral π-extended aromatic compounds consisting of two π–π stacked hexabenzocoronenes (HBCs) joined by a helicene,…”
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