Search Results - "Bedini, Annalida"

Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways by Lopez-Canul, Martha, Palazzo, Enza, Dominguez-Lopez, Sergio, Luongo, Livio, Lacoste, Baptiste, Comai, Stefano, Angeloni, Debora, Fraschini, Franco, Boccella, Serena, Spadoni, Gilberto, Bedini, Annalida, Tarzia, Giorgio, Maione, Sabatino, Granados-Soto, Vinicio, Gobbi, Gabriella

“…Neuropathic pain is an important public health problem for which only a few treatments are available. Preclinical studies show that melatonin (MLT), a…”
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Synthesis of Tryptamine Derivatives via a Direct, One-Pot Reductive Alkylation of Indoles by Righi, Marika, Topi, Francesca, Bartolucci, Silvia, Bedini, Annalida, Piersanti, Giovanni, Spadoni, Gilberto

“…An efficient, one-pot reductive alkylation of indoles with N-protected aminoethyl acetals in the presence of TES/TFA is reported. It represents the first…”
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Homology models of melatonin receptors: challenges and recent advances by Pala, Daniele, Lodola, Alessio, Bedini, Annalida, Spadoni, Gilberto, Rivara, Silvia

“…Melatonin exerts many of its actions through the activation of two G protein-coupled receptors (GPCRs), named MT1 and MT2. So far, a number of different MT1…”
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Melatonin MT1 and MT2 Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle by López-Canul, Martha, Min, Seung Hyun, Posa, Luca, De Gregorio, Danilo, Bedini, Annalida, Spadoni, Gilberto, Gobbi, Gabriella, Comai, Stefano

“…Melatonin (MLT) is a neurohormone that regulates many physiological functions including sleep, pain, thermoregulation, and circadian rhythms. MLT acts mainly…”
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Chiral Recognition of Flexible Melatonin Receptor Ligands Induced by Conformational Equilibria by Elisi, Gian Marco, Bedini, Annalida, Scalvini, Laura, Carmi, Caterina, Bartolucci, Silvia, Lucini, Valeria, Scaglione, Francesco, Mor, Marco, Rivara, Silvia, Spadoni, Gilberto

“…-anilinoethylamides are a class of melatoninergic agents with the aniline portion mimicking the indole ring of the natural ligand and the ethylamide chain…”
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COMBINED TARGETING OF FATTY ACID AMIDE HYDROLASE AND MELATONIN RECEPTORS PROMOTES NEUROPROTECTION AND STIMULATES INFLAMMATION RESOLUTION IN RATS by Cammarota, Mariarosaria, Ferlenghi, Francesca, Vacondio, Federica, Vincenzi, Fabrizio, Varani, Katia, Bedini, Annalida, Rivara, Silvia, Mor, Marco, Boscia, Francesca

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Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders by Rivara, Silvia, Mor, Marco, Bedini, Annalida, Spadoni, Gilberto, Tarzia, Giorgio

“…Melatonin (N-acetyl-5-methoxytryptamine) is synthesized and released by the pineal gland following a circadian rhythm characterized by high levels during the…”
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Synthesis and characterization of new bivalent agents as melatonin- and histamine H3-ligands by Pala, Daniele, Scalvini, Laura, Lodola, Alessio, Mor, Marco, Flammini, Lisa, Barocelli, Elisabetta, Lucini, Valeria, Scaglione, Francesco, Bartolucci, Silvia, Bedini, Annalida, Rivara, Silvia, Spadoni, Gilberto

“…Melatonin is an endogenous molecule involved in many pathophysiological processes. In addition to the control of circadian rhythms, its antioxidant and…”
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Analysis of Structure−Activity Relationships for MT2 Selective Antagonists by Melatonin MT1 and MT2 Receptor Models by Rivara, Silvia, Lorenzi, Simone, Mor, Marco, Plazzi, Pier Vincenzo, Spadoni, Gilberto, Bedini, Annalida, Tarzia, Giorgio

“…Three-dimensional homology models of human MT1 and MT2 melatonin receptors were built with the aim to investigate the structure−activity relationships (SARs)…”
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Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities by Mor, Marco, Silva, Claudia, Vacondio, Federica, Plazzi, Pier Vincenzo, Bertoni, Simona, Spadoni, Gilberto, Diamantini, Giuseppe, Bedini, Annalida, Tarzia, Giorgio, Zusso, Morena, Franceschini, Davide, Giusti, Pietro

“…:  The known neuroprotective actions of melatonin could be due to its antioxidant or radical scavenging activity, or they could be due to specific interactions…”
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Iridium-Catalyzed Direct Synthesis of Tryptamine Derivatives from Indoles: Exploiting N‑Protected β‑Amino Alcohols as Alkylating Agents by Bartolucci, Silvia, Mari, Michele, Bedini, Annalida, Piersanti, Giovanni, Spadoni, Gilberto

“…The selective C3-alkylation of indoles with N-protected ethanolamines involving the “borrowing hydrogen” strategy is described. This method provides convenient…”
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Combined targeting of fatty acid amide hydrolase and melatonin receptors promotes neuroprotection and stimulates inflammation resolution in rats by Cammarota, Mariarosaria, Ferlenghi, Francesca, Vacondio, Federica, Vincenzi, Fabrizio, Varani, Katia, Bedini, Annalida, Rivara, Silvia, Mor, Marco, Boscia, Francesca

“…Background and Purpose Devising novel strategies to therapeutically favour inflammation resolution and provide neuroprotection is an unmet clinical need…”
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MT2 selective melatonin receptor antagonists: design and structure-activity relationships by Rivara, Silvia, Mor, Marco, Lorenzi, Simone, Lodola, Alessio, Spadoni, Pier Vincenzo Plazzi Gilberto, Bedini, Annalida, Tarzia, Giorgio

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Dysfunction of serotonergic activity and emotional responses across the light‐dark cycle in mice lacking melatonin  MT2 receptors by Comai, Stefano, De Gregorio, Danilo, Posa, Luca, Ochoa‐Sanchez, Rafael, Bedini, Annalida, Gobbi, Gabriella

“…Melatonin (MLT) levels fluctuate according to the external light/dark cycle in both diurnal and nocturnal mammals. We previously demonstrated that…”
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Industrial and academic approaches to the search for alternative melatonin receptor ligands: An historical survey by Bedini, Annalida, Boutin, Jean A., Legros, Céline, Zlotos, Darius P., Spadoni, Gilberto

“…The search for melatonin receptor agonists formed the main part of melatonin medicinal chemistry programs for the last three decades. In this short review, we…”
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Design, Synthesis, and Biological Activity of Hydrogen Peroxide Responsive Arylboronate Melatonin Hybrids by Bedini, Annalida, Fraternale, Alessandra, Crinelli, Rita, Mari, Michele, Bartolucci, Silvia, Chiarantini, Laura, Spadoni, Gilberto

“…Stimulus-responsive cleavage reactions have found broad use to direct drug release at a particular target disease area. Increased levels of reactive oxygen…”
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Therapeutic uses of melatonin and melatonin derivatives: a patent review (2012 - 2014) by Rivara, Silvia, Pala, Daniele, Bedini, Annalida, Spadoni, Gilberto

“…Melatonin is a neurohormone involved in the regulation of circadian rhythms, with potent antioxidant activity. It has a wide functional repertoire, with…”
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Binding and unbinding of potent melatonin receptor ligands: Mechanistic simulations and experimental evidence by Bedini, Annalida, Elisi, Gian Marco, Fanini, Fabiola, Retini, Michele, Scalvini, Laura, Pasquini, Silvia, Contri, Chiara, Varani, Katia, Spadoni, Gilberto, Mor, Marco, Vincenzi, Fabrizio, Rivara, Silvia

“…The labeled ligand commonly employed in competition binding studies for melatonin receptor ligands, 2‐[125I]iodomelatonin, showed slow dissociation with…”
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In silico drug discovery of melatonin receptor ligands with therapeutic potential by Elisi, Gian Marco, Scalvini, Laura, Lodola, Alessio, Bedini, Annalida, Spadoni, Gilberto, Rivara, Silvia

“…The neurohormone melatonin ( -acetyl-5-methoxytryptamine) regulates circadian rhythms exerting a variety of effects in the central nervous system and in…”
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2-Arylmelatonin analogues: Probing the 2-phenyl binding pocket of melatonin MT1 and MT2 receptors by Mari, Michele, Elisi, Gian Marco, Bedini, Annalida, Lucarini, Simone, Retini, Michele, Lucini, Valeria, Scaglione, Francesco, Vincenzi, Fabrizio, Varani, Katia, Castelli, Riccardo, Mor, Marco, Rivara, Silvia, Spadoni, Gilberto

“…In crystal structures of melatonin MT1 and MT2 receptors, a lipophilic subpocket has been characterized which accommodates the phenyl ring of the potent…”
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