Search Results - "Bedi, Mel F."

Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking by Audat, Suaad A, Al-Shar'i, Nizar A, Al-Oudat, Buthina A, Bryant-Friedrich, Amanda, Bedi, Mel F, Zayed, Aref L, Al-Balas, Qosay A

“…Leukotriene B4 (LTB4) is a potent, proinflammatory lipid mediator implicated in the pathologies of an array of inflammatory diseases and cancer. The…”
Get full text

Novel Chrysin-De-Allyl PAC-1 Hybrid Analogues as Anticancer Compounds: Design, Synthesis, and Biological Evaluation by Al-Oudat, Buthina A, Ramapuram, Hariteja, Malla, Saloni, Audat, Suaad A, Hussein, Noor, Len, Jenna M, Kumari, Shikha, Bedi, Mel F, Ashby, Jr, Charles R, Tiwari, Amit K

“…New chrysin-De-allyl-Pac-1 hybrid analogues, tethered with variable heterocyclic systems ( - ), were rationally designed and synthesized. The target compounds…”
Get full text

Design, synthesis and biological evaluation of novel glyoxalase I inhibitors possessing diazenylbenzenesulfonamide moiety as potential anticancer agents by Al-Oudat, Buthina A., Jaradat, Hana'a M., Al‑Balas, Qosay A., Al-Shar'i, Nizar A., Bryant-Friedrich, Amanda, Bedi, Mel F.

“…[Display omitted] The enzyme glyoxalase-I (Glo-I) is an essential therapeutic target in cancer treatment. Significant efforts have been made to discover…”
Get full text

Synthesis of damaged DNA containing the oxidative lesion 3′-oxothymidine by Bedi, Mel F., Li, Weiye, Gutwald, Taylor, Bryant-Friedrich, Amanda C.

“…[Display omitted] Oxidative events that take place during regular oxygen metabolism can lead to the formation of organic or inorganic radicals. The interaction…”
Get full text