Search Results - "Bedell, Victoria M."

Using engineered endonucleases to create knockout and knockin zebrafish models by Bedell, Victoria M, Ekker, Stephen C

“…Over the last few years, the technology to create targeted knockout and knockin zebrafish animals has exploded. We have gained the ability to create targeted…”
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In vivo protein trapping produces a functional expression codex of the vertebrate proteome by Clark, Karl J, Balciunas, Darius, Pogoda, Hans-Martin, Ding, Yonghe, Westcot, Stephanie E, Bedell, Victoria M, Greenwood, Tammy M, Urban, Mark D, Skuster, Kimberly J, Petzold, Andrew M, Ni, Jun, Nielsen, Aubrey L, Patowary, Ashok, Scaria, Vinod, Sivasubbu, Sridhar, Xu, Xiaolei, Hammerschmidt, Matthias, Ekker, Stephen C

“…A protein-trap mutagenesis system efficiently disrupts expression and reports endogenous expression patterns of genes in the zebrafish. The authors used it to…”
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Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia by McKinstry-Wu, Andrew R, Wasilczuk, Andrzej Z, Harrison, Benjamin A, Bedell, Victoria M, Sridharan, Mathangi J, Breig, Jayce J, Pack, Michael, Kelz, Max B, Proekt, Alexander

“…Traditionally, drug dosing is based on a concentration-response relationship estimated in a population. Yet, in specific individuals, decisions based on the…”
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Nicotine response genetics in the zebrafish by Petzold, Andrew M, Balciunas, Darius, Sivasubbu, Sridhar, Clark, Karl J, Bedell, Victoria M, Westcot, Stephanie E, Myers, Shelly R, Moulder, Gary L, Thomas, Mark J, Ekker, Stephen C

“…Tobacco use is predicted to result in over 1 billion deaths worldwide by the end of the 21st century. How genetic variation contributes to the observed…”
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roundabout4 Is Essential for Angiogenesis in vivo by Bedell, Victoria M., Yeo, Sang-Yeob, Park, Kye Won, Chung, Jeffrey, Seth, Pankaj, Shivalingappa, Venkatesha, Zhao, Jinhua, Obara, Tomoko, Sukhatme, Vikas P., Drummond, Iain A., Li, Dean Y., Ramchandran, Ramani, Anderson, Kathryn V.

“…Stereotypical patterns of vascular and neuronal networks suggest that specific genetic programs tightly control path determination and, consequently,…”
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Robo4 Signaling in Endothelial Cells Implies Attraction Guidance Mechanisms by Kaur, Sukhbir, Castellone, Maria Domenica, Bedell, Victoria M., Konar, Martha, Gutkind, J. Silvio, Ramchandran, Ramani

“…Roundabouts (robo) are cell-surface receptors that mediate repulsive signaling mechanisms at the central nervous system midline. However, robos may also…”
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Expression of sclerostin in the developing zebrafish (Danio rerio) brain and skeleton by McNulty, Melissa S., Bedell, Victoria M., Greenwood, Tammy M., Craig, Theodore A., Ekker, Stephen C., Kumar, Rajiv

“…► Sclerostin (sost) RNA is expressed early (15hpf) in Danio rerio. ► Sost expression is seen in the developing brain. ► Sost is expressed in developing…”
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Vascular Endothelial Growth Factor as an Immediate-Early Activator of Ultraviolet-Induced Skin Injury by Hartono, Stella P., Bedell, Victoria M., Alam, Sk. Kayum, O'Gorman, Madelyn, Serres, MaKayla, Hall, Stephanie R., Pal, Krishnendu, Kudgus, Rachel A., Mukherjee, Priyabrata, Seelig, Davis M., Meves, Alexander, Mukhopadhyay, Debabrata, Ekker, Stephen C., Hoeppner, Luke H.

“…The negative health consequences of acute ultraviolet (UV) exposure are evident, with reports of 30,000 emergency room visits annually to treat the effects of…”
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A vertebrate model to reveal neural substrates underlying the transitions between conscious and unconscious states by Bedell, Victoria M., Meng, Qing C., Pack, Michael A., Eckenhoff, Roderic G.

“…The field of neuropharmacology has not yet achieved a full understanding of how the brain transitions between states of consciousness and drug-induced…”
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Lessons from morpholino-based screening in zebrafish by Bedell, Victoria M., Westcot, Stephanie E., Ekker, Stephen C.

“…Morpholino oligonucleotides (MOs) are an effective, gene-specific antisense knockdown technology used in many model systems. Here we describe the application…”
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RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells by Hoeppner, Luke H, Sinha, Sutapa, Wang, Ying, Bhattacharya, Resham, Dutta, Shamit, Gong, Xun, Bedell, Victoria M, Suresh, Sandip, Chun, Changzoon, Ramchandran, Ramani, Ekker, Stephen C, Mukhopadhyay, Debabrata

“…Vasculogenesis and angiogenesis are controlled by vascular endothelial growth factor A (VEGF-A). Dysregulation of these physiological processes contributes to…”
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The future of research in anesthesiology by Lane-Fall, Meghan B., Bedell, Victoria M., Eckenhoff, Roderic G.

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In vivo genome editing using a high-efficiency TALEN system by Bedell, Victoria M., Wang, Ying, Campbell, Jarryd M., Poshusta, Tanya L., Starker, Colby G., Krug II, Randall G., Tan, Wenfang, Penheiter, Sumedha G., Ma, Alvin C., Leung, Anskar Y. H., Fahrenkrug, Scott C., Carlson, Daniel F., Voytas, Daniel F., Clark, Karl J., Essner, Jeffrey J., Ekker, Stephen C.

“…Although zebrafish is an important animal model for basic vertebrate biology and human disease modelling, rapid targeted genome modification has not been…”
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Synthesis and Characterization of a Diazirine-Based Photolabel of the Nonanesthetic Fropofol by White, E Railey, Leace, David M, Bedell, Victoria M, Bhanu, Natarajan V, Garcia, Benjamin A, Dailey, William P, Eckenhoff, Roderic G

“…The mechanisms of general anesthetics have been debated in the literature for many years and continue to be of great interest. As anesthetic molecules are…”
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Correction: RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells (doi:10.1242/jcs.167601) by Hoeppner, Luke H, Sinha, Sutapa, Wang, Ying, Bhattacharya, Resham, Dutta, Shamit, Gong, Xun, Bedell, Victoria M, Suresh, Sandip, Chun, Changzoon, Ramchandran, Ramani, Ekker, Stephen C, Mukhopadhyay, Debabrata

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Nervy Vasculature by Bedell, Victoria M, Ekker, Stephen C

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The lineage-specific gene ponzr1 is essential for zebrafish pronephric and pharyngeal arch development by Bedell, Victoria M, Person, Anthony D, Larson, Jon D, McLoon, Anna, Balciunas, Darius, Clark, Karl J, Neff, Kevin I, Nelson, Katie E, Bill, Brent R, Schimmenti, Lisa A, Beiraghi, Soraya, Ekker, Stephen C

“…The Homeobox (Hox) and Paired box (Pax) gene families are key determinants of animal body plans and organ structure. In particular, they function within…”
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The ins and outs of VEGF signaling by Ekker, Stephen C., Bedell, Victoria M.

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SCORE imaging: specimen in a corrected optical rotational enclosure by Petzold, Andrew M, Bedell, Victoria M, Boczek, Nicole J, Essner, Jeffrey J, Balciunas, Darius, Clark, Karl J, Ekker, Stephen C

“…Visual data collection is paramount for the majority of scientific research. The added transparency of the zebrafish (Danio rerio) allows for a greater detail…”
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Photodetachment of Zwitterions:  Probing Intramolecular Coulomb Repulsion and Attraction in the Gas Phase Using Mono-decarboxylated Pyridinium Dicarboxylates. Implications on the Mechanism of Orotidine 5‘-Monophosphate Decarboxylase by Wang, Xue-Bin, Dacres, Jelena E, Yang, Xin, Lis, Lev, Bedell, Victoria M, Wang, Lai-Sheng, Kass, Steven R

“…Negative ion photoelectron spectra resulting from the decarboxylation of nine zwitterionic pyridinium dicarboxylates (D(x,y)) are reported. Structural…”
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