Search Results - "Bedell, M A"

Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18 by HUDSON, J. B, BEDELL, M. A, MCCANCE, D. J, LAIMINS, L. A

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Steel-Dickie Mutation Encodes a c-Kit Ligand Lacking Transmembrane and Cytoplasmic Domains by Brannan, Camilynn I., Lyman, Stewart D., Williams, Douglas E., Eisenman, June, Anderson, Dirk M., Cosman, David, Bedell, Mary A., Jenkins, Nancy A., Copeland, Neal G.

“…Mice homozygous for the viable Sl allele steel-Dickie (Sld) are sterile, severely anemic, and black-eyed white. The nature of the Sldmutation was investigated…”
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Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation by BEDELL, M. A, HUDSON, J. B, GOLUB, T. R, TURYK, M. E, HOSKEN, M, WILBANKS, G. D, LAIMINS, L. A

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Identification of human papillomavirus type 18 transforming genes in immortalized and primary cells by BEDELL, M. A, JONES, K. H, GROSSMAN, S. R, LAIMINS, L. A

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The E6-E7 region of human papillomavirus type 18 is sufficient for transformation of NIH 3T3 and rat-1 cells by BEDELL, M. A, JONES, K. H, LAIMINS, L. A

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An allelic series of mutations in the Kit ligand gene of mice. II. Effects of ethylnitrosourea-induced Kitl point mutations on survival and peripheral blood cells of Kitl(Steel) mice by Rajaraman, S, Davis, W S, Mahakali-Zama, A, Evans, H K, Russell, L B, Bedell, M A

“…The ligand for the Kit receptor tyrosine kinase is Kit ligand (Kitl; also known as mast cell growth factor, stem cell factor, and Steel factor), which is…”
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An allelic series of mutations in the kit ligand gene of mice. I. Identification of point mutations in seven ethylnitrosourea-induced Kitl(Steel) alleles by Rajaraman, S, Davis, W S, Mahakali-Zama, A, Evans, H K, Russell, L B, Bedell, M A

“…An allelic series of mutations is an extremely valuable genetic resource for understanding gene function. Here we describe eight mutant alleles at the Steel…”
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Inducible and constitutive enhancer domains in the noncoding region of human papillomavirus type 18 by GIUS, D, GROSSMAN, S, BEDELL, M. A, LAIMINS, L. A

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Deletion and Interallelic Complementation Analysis of Steel Mutant Mice by Bedell, M. A, Cleveland, L. S, O'Sullivan, T. N, Copeland, N. G, Jenkins, N. A

“…Mutations at the Steel (Sl) locus produce pleiotropic effects on viability as well as hematopoiesis, pigmentation and fertility. Several homozygous viable Sl…”
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The Murine Interleukin-3 Receptor α Subunit Gene: Chromosomal Localization, Genomic Structure, and Promoter Function by Miyajima, Ikuko, Levitt, Lee, Hara, Takahiko, Bedell, Mary A., Copeland, Neal G., Jenkins, Nancy A., Miyajima, Atsushi

“…The interleukin-3 receptor (IL-3R) is composed of α and β subunits, members of the class I cytokine receptor family. Here we describe isolation and…”
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Molecular cloning and biological characterization of a novel murine lymphoid growth factor by Sims, J E, Williams, D E, Morrissey, P J, Garka, K, Foxworthe, D, Price, V, Friend, S L, Farr, A, Bedell, M A, Jenkins, N A, Copeland, N G, Grabstein, K, Paxton, R J

“…Using a bioassay consisting of the proliferation of a murine B cell line, a cDNA of a gene whose product supports the growth of that cell line was isolated…”
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Multiple pathways for Steel regulation suggested by genomic and sequence analysis of the murine Steel gene by Bedell, M A, Copeland, N G, Jenkins, N A

“…The Steel (Sl) locus encodes mast cell growth factor (Mgf) that is required for the development of germ cells, hematopoietic cells and melanocytes. Although…”
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Mouse models of human disease. Part II: recent progress and future directions by Bedell, M A, Largaespada, D A, Jenkins, N A, Copeland, N G

“…The development of new methods for manipulating the mouse genome, including transgenic and embryonic stem (ES) cell knockout technology, combined with greatly…”
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CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome by Allen, R. Cutler, Armitage, Richard J., Conley, Mary Ellen, Rosenblatt, Howard, Jenkins, Nancy A., Copeland, Neal G., Bedell, Mary A., Edelhoff, Susanne, Disteche, Christine M., Simoneaux, Denise K., Fanslow, William C., Belmont, John, Spriggs, Melanie K.

“…The ligand for CD40 (CD40L) is a membrane glycoprotein on activated T cells that induces B cell proliferation and immunoglobulin secretion. Abnormalities in…”
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Mouse models of human disease. Part I: techniques and resources for genetic analysis in mice by Bedell, M A, Jenkins, N A, Copeland, N G

“…The mouse is an ideal model organism for human disease. Not only are mice physiologically similar to humans, but a large genetic reservoir of potential models…”
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DNA rearrangements located over 100 kb 5' of the Steel (Sl)-coding region in Steel-panda and Steel-contrasted mice deregulate Sl expression and cause female sterility by disrupting ovarian follicle development by Bedell, M A, Brannan, C I, Evans, E P, Copeland, N G, Jenkins, N A, Donovan, P J

“…The Steel (Sl) locus is essential for the development of germ cells, hematopoietic cells, and melanocytes and encodes a growth factor (Mgf) that is the ligand…”
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Gene structure and chromosomal localization of the mouse NMDA receptor channel subunits by Nagasawa, Michiaki, Sakimura, Kenji, Mori, Kazuhiro J., Bedell, Mary A., Copeland, Neal G., Jenkins, Nancy A., Mishina, Masayoshi

“…Multiple ϵ subunits are major determinants of the diversity of the N-methyl- d-aspartate (NMDA) receptor channel. The four ϵ subunit mRNAs exhibit distinct…”
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Cell-Specific Differences in O6-alkylguanine DNA Repair Activity during Continuous Exposure to Carcinogen by Swenberg, James A., Bedell, Mary A., Billings, Kathryn C., Umbenhauer, Diane R., Pegg, Anthony E.

“…The activity of the alkyl acceptor protein (AAP) responsible for repair of DNA containing the promutagenic lesion O6-alkylguanine was determined in hepatocytes…”
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An Allelic Series of Mutations in the Kit ligand Gene of Mice. II. Effects of Ethylnitrosourea-Induced Kitl Point Mutations on Survival and Peripheral Blood Cells of KitlSteel Mice by Rajaraman, S, Davis, W. S, Mahakali-Zama, A, Evans, H. K, Russell, L. B, Bedell, M. A

“…The ligand for the Kit receptor tyrosine kinase is Kit ligand (Kitl; also known as mast cell growth factor, stem cell factor, and Steel factor), which is…”
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Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail by BRANNAN, C. I, BEDELL, M. A, RESNICK, J. L, EPPIG, J. J, HANDEL, M. A, WILLIAMS, D. E, LYMAN, S. D, DONOVAN, P. J, JENKINS, N. A, COPELAND, N. G

“…The murine dominant White spotting (W) and Steel (Sl) loci encode the c-kit tyrosine kinase receptor and its cognate ligand steel factor (SLF), respectively…”
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