Search Results - "Beddow, Sara"

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease by Kumashiro, Naoki, Erion, Derek M, Zhang, Dongyan, Kahn, Mario, Beddow, Sara A, Chu, Xin, Still, Christopher D, Gerhard, Glenn S, Han, Xianlin, Dziura, James, Petersen, Kitt Falk, Samuel, Varman T, Shulman, Gerald I

“…Insulin resistance is associated with nonalcoholic fatty liver disease (NAFLD) and is a major factor in the pathogenesis of type 2 diabetes. The development of…”
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FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis by Kir, Serkan, Beddow, Sara A., Samuel, Varman T., Miller, Paul, Previs, Stephen F., Suino-Powell, Kelly, Xu, H. Eric, Shulman, Gerald I., Kliewer, Steven A., Mangelsdorf, David J.

“…Fibroblast growth factor (FGF) 19 is an enterokine synthesized and released when bile acids are taken up into the ileum. We show that FGF19 stimulates hepatic…”
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Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance by KUMASHIRO, Naoki, BEDDOW, Sara A, KAHN, Mario, PERLER, Bryce K, PUCHOWICZ, Michelle A, VARA PRASAD MANCHEM, BHANOT, Sanjay, STILL, Christopher D, GERHARD, Glenn S, PETERSEN, Kitt Falk, CLINE, Gary W, SHULMAN, Gerald I, VATNER, Daniel F, SAMUEL, Varman T, MAJUMDAR, Sachin K, CANTLEY, Jennifer L, GUEBRE-EGZIABHER, Fitsum, FAT, Ioana, GUIGNI, Blas, JURCZAK, Michael J, BIRKENFELD, Andreas L

“…We measured the mRNA and protein expression of the key gluconeogenic enzymes in human liver biopsy specimens and found that only hepatic pyruvate carboxylase…”
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Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes by Samuel, Varman T, Beddow, Sara A, Iwasaki, Takanori, Zhang, Xian-Man, Chu, Xin, Still, Christopher D, Gerhard, Glenn S, Shulman, Gerald I

“…Fasting hyperglycemia in patients with type 2 diabetes mellitus (T2DM) is attributed to increased hepatic gluconeogenesis, which has been ascribed to increased…”
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Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways by Vatner, Daniel F, Weismann, Dirk, Beddow, Sara A, Kumashiro, Naoki, Erion, Derek M, Liao, Xiao-Hui, Grover, Gary J, Webb, Paul, Phillips, Kevin J, Weiss, Roy E, Bogan, Jonathan S, Baxter, John, Shulman, Gerald I, Samuel, Varman T

“…Liver-specific thyroid hormone receptor-β (TRβ)-specific agonists are potent lipid-lowering drugs that also hold promise for treating nonalcoholic fatty liver…”
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Targeting the GM-CSF receptor for the treatment of CNS autoimmunity by Ifergan, Igal, Davidson, Todd S, Kebir, Hania, Xu, Dan, Palacios-Macapagal, Daphne, Cann, Jennifer, Rodgers, Jane M, Hunter, Zoe N, Pittet, Camille L, Beddow, Sara, Jones, Clare A, Prat, Alexandre, Sleeman, Matthew A, Miller, Stephen D

“…Abstract In multiple sclerosis (MS), there is a growing interest in inhibiting the pro-inflammatory effects of granulocyte-macrophage colony-stimulating factor…”
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PEPCK1 Antisense Oligonucleotide Prevents Adiposity and Impairs Hepatic Glycogen Synthesis in High-Fat Male Fed Rats by Beddow, Sara A, Gattu, Arijeet K, Vatner, Daniel F, Paolella, Lauren, Alqarzaee, Abdulelah, Tashkandi, Nedda, Popov, Violeta B, Church, Christopher D, Rodeheffer, Matthew S, Cline, Gary W, Geisler, John G, Bhanot, Sanjay, Samuel, Varman T

“…Abstract The increased hepatic gluconeogenesis in type 2 diabetes mellitus has often been ascribed to increased transcription of phosphoenolpyruvate…”
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Hepatic glucose production pathways after three days of a high-fat diet by Jin, Eunsook S, Beddow, Sara A, Malloy, Craig R, Samuel, Varman T

“…Abstract Objective A three-day high-fat diet induces hepatic steatosis and hepatic insulin resistance in rats without altering fasting plasma glucose…”
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Tolerance Induced by Antigen-Loaded PLG Nanoparticles Affects the Phenotype and Trafficking of Transgenic CD4 + and CD8 + T Cells by Neef, Tobias, Ifergan, Igal, Beddow, Sara, Penaloza-MacMaster, Pablo, Haskins, Kathryn, Shea, Lonnie D, Podojil, Joseph R, Miller, Stephen D

“…We have shown that PLG nanoparticles loaded with peptide antigen can reduce disease in animal models of autoimmunity and in a phase 1/2a clinical trial in…”
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Fasting hyperglycemia in the Goto-Kakizaki rat is dependent on corticosterone: a confounding variable in rodent models of type 2 diabetes by Beddow, Sara A, Samuel, Varman T

“…The Goto-Kakizaki (GK) rat is an inbred model of type 2 diabetes (T2D); GK rats are lean but have hyperglycemia and increased gluconeogenesis. However, fasting…”
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Immune-Modifying Microparticles for Treatment of Acute Graft-Versus-Host-Disease by Beddow, Sara A, Lust, Hannah, Galvin, John, Miller, Stephen D

“…Abstract Background: Acute Graft versus host disease (aGVHD) is one of the most common complication of allogeneic hematopoietic stem cell transplant. We have…”
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The Therapeutic Effect of Immune-Modifying Microparticles in Acute Graft-Versus-Host Disease by Galvin, John P, Beddow, Sara A, Miller, Stephen

“…Introduction Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important therapy for hematologic malignancies. The success of allo-HSCT is…”
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Treatment with Multiple-linked Myelin Peptides Encapsulated within Nanoparticles Induces Antigen-specific Tolerance in SJL/J Relapsing-remitting Experimental Autoimmune Encephalomyelitis by Beddow, Sara A, Neef, Tobias, Ifergan, Igal, Podojil, Joseph R, Getts, Daniel, Miller, Stephen D

“…Abstract Experimental autoimmune encephalomyelitis (EAE) in SJL/J mice is a demyelinating disease of the central nervous system (CNS), and serves as a…”
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Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease by Samuel, Varman T., Liu, Zhen-Xiang, Wang, Amy, Beddow, Sara A., Geisler, John G., Kahn, Mario, Zhang, Xian-man, Monia, Brett P., Bhanot, Sanjay, Shulman, Gerald I.

“…Nonalcoholic fatty liver disease is strongly associated with hepatic insulin resistance and type 2 diabetes mellitus, but the molecular signals linking hepatic…”
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351 - Immune-Modifying Microparticles for Treatment of Acute Graft-Versus-Host-Disease by Lust, Hannah, Beddow, Sara A, Galvin, John, Miller, Stephen D

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Immune-Modifying Microparticles for Treatment of Acute Graft-Versus-Host-Disease by Lust, Hannah, Beddow, Sara A, Galvin, John, Miller, Stephen D

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The Therapeutic Effect of Immune-Modifying Microparticles in an Acute Graft-Versus-Host Disease Model by Galvin, John P., Beddow, Sara A., Miller, Stephen

“…Inflammatory monocytes are recruited to target organs during acute Graft versus Host Disease (aGVHD). As seen in other autoimmune disorders, inflammatory…”
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Inhibition of protein kinase C[epsilon] prevents hepatic insulin resistance in nonalcoholic fatty liver disease by Samuel, Varman T, Zhen-Xiang, Liu, Wang, Amy, Beddow, Sara A

“…Nonalcoholic fatty liver disease is strongly associated with hepatic insulin resistance and type 2 diabetes mellitus, but the molecular signals linking hepatic…”
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Assessment of Axonal Growth into Collagen Nerve Guides Containing VEGF‐Transfected Stem Cells in Matrigel by Kempton, Laurence B., Gonzalez, Mark H., Leven, Robert M., Hughes, W. Frank, Beddow, Sara, Santhiraj, Yaveen, Archibald, Simon J., El Hassan, Bassem, Shott, Susan, Kerns, James M.

“…The early events associated with axonal growth into 10‐mm nerve gaps were studied histologically in the rat sciatic nerve model to determine if the outgrowth…”
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Inhibition of protein kinase Cζ prevents hepatic insulin resistance in nonalcoholic fatty liver disease by Samuel, Varman T, Liu, Zhen-Xiang, Wang, Amy, Beddow, Sara A, Geisler, John G, Kahn, Mario, Zhang, Xian-man, Monia, Brett P, Bhanot, Sanjay, Shulman, Gerald I

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