Search Results - "Bedding, Alun W"

Adaptive designs in clinical trials: why use them, and how to run and report them by Pallmann, Philip, Bedding, Alun W, Choodari-Oskooei, Babak, Dimairo, Munyaradzi, Flight, Laura, Hampson, Lisa V, Holmes, Jane, Mander, Adrian P, Odondi, Lang'o, Sydes, Matthew R, Villar, Sofía S, Wason, James M S, Weir, Christopher J, Wheeler, Graham M, Yap, Christina, Jaki, Thomas

“…Adaptive designs can make clinical trials more flexible by utilising results accumulating in the trial to modify the trial's course in accordance with…”
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Tadalafil pharmacokinetics in healthy subjects by Forgue, S. Thomas, Patterson, Beverley E., Bedding, Alun W., Payne, Christopher D., Phillips, Diane L., Wrishko, Rebecca E., Mitchell, Malcolm I.

“…Aims To characterize tadalafil plasma pharmacokinetics in healthy subjects following single and multiple doses. Methods Noncompartmental parameters were…”
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Effects of gender, age, diabetes mellitus and renal and hepatic impairment on tadalafil pharmacokinetics by Forgue, S. Thomas, Phillips, Diane L., Bedding, Alun W., Payne, Christopher D., Jewell, Hayley, Patterson, Beverley E., Wrishko, Rebecca E., Mitchell, Malcolm I.

“…Aims To evaluate the effects of gender, age, diabetes mellitus, renal and hepatic impairment on tadalafil pharmacokinetics and tolerability. Methods Six…”
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Effect of Tadalafil on Cytochrome P450 3A4-mediated Clearance: Studies in Vitro and in Vivo by Ring, Barbara J., Patterson, Beverley E., Mitchell, Malcolm I., Vandenbranden, Mark, Gillespie, Jennifer, Bedding, Alun W., Jewell, Hayley, Payne, Christopher D., Forgue, S. Thomas, Eckstein, James, Wrighton, Steven A., Phillips, Diane L.

“…Objectives Tadalafil was examined in vitro and in vivo for its ability to affect human cytochrome P450 (CYP) 3A‐mediated metabolism. Methods Reversible and…”
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The Combined Use of Ibutilide as an Active Control With Intensive Electrocardiographic Sampling and Signal Averaging as a Sensitive Method to Assess the Effects of Tadalafil on the Human QT Interval by Beasley, Charles M., Mitchell, Malcolm I., Dmitrienko, Alex A., Emmick, Jeffrey T., Shen, Wei, Costigan, Timothy M., Bedding, Alun W., Turik, Michael A., Bakhtyari, Arash, Warner, Margaret R., Ruskin, Jeremy N., Cantilena, Louis R., Kloner, Robert A.

“…This study was designed to evaluate effects of tadalafil, a phosphodiesterase-5 inhibitor used for the treatment of erectile dysfunction (ED), on the QT…”
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A Phase II Study of the Safety and Efficacy of a Novel Oral fXa Inhibitor (LY517717) for the Prevention of Venous Thromboembolism Following TKR or THR by Agnelli, Giancarlo, Haas, Sylvia K., Krueger, Kathryn A., Bedding, Alun W., Brandt, John T.

“…Background: There is a continuing need for safe, effective and convenient therapies for prophylaxis of venous thromboembolism (VTE) after major orthopedic…”
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The bayesian analysis of dose titration to effect in phase 2 clinical trials in order to design phase 3 by Bedding, Alun W

“…This thesis deals with the design and analysis of dose titration studies in Phase II clinical trials in order to predict the dosing in Phase III to give the…”
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The combined use of ibutilide as an active control with intensive electrocardiographic sampling and signal averaging as a sensitive method to assess the effects of tadalafil on the human QT interval. Commentary by BEASLEY, Charles M, MITCHELL, Malcolm I, RUSKIN, Jeremy N, CANTILENA, Louis R, KLONER, Robert A, KOWEY, Peter R, YAN, Gan-Xin, DMITRIENKO, Alex A, EMMICK, Jeffrey T, WEI SHEN, COSTIGAN, Timothy M, BEDDING, Alun W, TURIK, Michael A, BAKHTYARI, Arash, WARNER, Margaret R

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