Search Results - "Beddell, Christopher R"

Mass Spectrometry of the Humanized Monoclonal Antibody Campath 1H by Ashton, David S, Beddell, Christopher R, Cooper, David J, Craig, Sarah J, Lines, Anne C, Oliver, Ronald W. A, Smith, Marjorie A

“…Two mass spectrometric techniques, electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) have been used to study the intact…”
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Pyrrolo[2,3- d]pyrimidines and pyrido[2,3- d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim by Kuyper, Lee F, Garvey, Janice M, Baccanari, David P, Champness, John N, Stammers, David K, Beddell, Christopher R

“…Conformationally restricted analogues of the antibacterial agent trimethoprim (TMP) were designed to mimic the conformation of drug observed in its complex…”
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NMR spectroscopy of human post mortem cerebrospinal fluid: distinction of Alzheimer's disease from control using pattern recognition and statistics by Ghauri, F Y, Nicholson, J K, Sweatman, B C, Wood, J, Beddell, C R, Lindon, J C, Cairns, N J

“…1H NMR spectra have been measured at 500 and 600 MHz on 23 human cerebrospinal fluid samples obtained at autopsy from Alzheimer's disease patients and…”
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Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs by Kuyper, Lee F, Roth, Barbara, Baccanari, David P, Ferone, Robert, Beddell, Christopher R, Champness, John N, Stammers, David K, Dann, John G, Norrington, Frank E. A

“…By the use of molecular models of Escherichia coli dihydrofolate reductase (DHFR), analogues of trimethoprim (TMP) were designed which incorporated various…”
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Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs by Kuyper, Lee F, Roth, Barbara, Baccanari, David P, Ferone, Robert, Beddell, Christopher R, Champness, John N, Stammers, David K, Dann, John G, Norrington, Frank E. A

“…The author report here the design, synthesis, DHFR affinity, and X-ray crystallographic binding analysis of a series of 3'-carboxyalkoxy analogues of TMP. At…”
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Pseudosymmetry in the structure of luteinizing hormone-releasing hormone. Series of novel analogs by Beddell, Christopher R, Fraser, Peter J, Gilbert, David, Goodford, Peter J, Lowe, Lawrence A, Wilkinson, Samuel

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Studies of the biochemical toxicology of uranyl nitrate in the rat by ANTHONY, M. L, GARTLAND, K. P. R, BEDDELL, C. R, LINDON, J. C, NICHOLSON, J. K

“…High resolution 1H NMR spectroscopy of urine and plasma, conventional clinical chemical methods and histopathology have been applied to investigate the effects…”
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Determination of carbohydrate heterogeneity in the humanised antibody CAMPATH 1H by liquid chromatography and matrix-assisted laser desorption ionisation mass spectrometry by Ashton, David S., Beddell, Christopher R., Cooper, David J., Lines, Anne C.

“…The carbohydrate heterogeneity in a humanised immunoglobulin CAMPATH 1H has been evaluated by liquid chromatography (LC) and matrix-assisted laser desorption…”
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Quantitative structure-metabolism relationships for substituted benzoic acids in the rat. Computational chemistry, NMR spectroscopy and pattern recognition studies by Ghauri, F Y, Blackledge, C A, Glen, R C, Sweatman, B C, Lindon, J C, Beddell, C R, Wilson, I D, Nicholson, J K

“…An extensive set of computed molecular properties, both steric and electronic, have been calculated using molecular orbital and empirical methods for benzoic…”
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Studies on the comparative toxicity of S-(1,2-dichlorovinyl)-L-cysteine, S-(1,2-dichlorovinyl)-L-homocysteine and 1,1,2-trichloro-3,3,3-trifluoro-1-propene in the fischer 344 rat by ANTHONY, M. L, BEDDELL, C. R, LINDON, J. C, NICHOLSON, J. K

“…The renal tubular toxicity of various halogenated xenobiotics has been attributed to their enzymatic bioactivation to reactive intermediates by S-conjugation…”
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Cephaloridine-induced nephrotoxicity in the Fischer 344 rat: proton NMR spectroscopic studies of urine and plasma in relation to conventional clinical chemical and histopathological assessments of nephronal damage by Anthony, M L, Gartland, K P, Beddell, C R, Lindon, J C, Nicholson, J K

“…The acute toxicological effects of the nephrotoxic antibiotic cephaloridine (CPH, 0-1500 mg/kg) in male Fischer 344 (F344) rats, have been investigated over 48…”
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Studies of the biochemical toxicology of uranyl nitratein the rat by Anthony, Maria L., Gartland, Kevin P. R., Beddell, Christopher R., Lindon, John C., Nicholson, Jeremy K.

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Studies on the effects ofl(αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125) on 4-aminophenol-induced nephrotoxicity in the Fischer 344 rat by Anthony, Maria L., Beddell, Christopher R., Lindon, John C., Nicholson, Jeremy K.

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Some electrospray mass spectrometric evidence for the existence of covalent O-acyl enzyme intermediates by Ashton, David S., Beddell, Christopher R., Cooper, David J., Green, Brian N., Oliver, Ronald W.A., Welham, Kevin J.

“…Electrospray mass spectrometry has been used to measure the masses of the species present in solutions of three serine proteases (α-chymotrypsin, subtilisin…”
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Studies on the effects of L(αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125) on 4-aminophenol-induced nephrotoxicity in the Fischer 344 rat by ANTHONY, M. L, BEDDELL, C. R, LINDON, J. C, NICHOLSON, J. K

“…4-Aminophenol (para-aminophenol; PAP) causes selective necrosis to the S3 segment of the proximal tubule in experimental animals. The mechanism of PAP…”
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Pseudosymmetry in the structure of luteinizing hormone-releasing hormone. Studies on a series of novel analogs by Beddell, C R, Fraser, P J, Gilbert, D, Goodford, P J, Lowe, L A, Wilkinson, S

“…Pseudosymmetry in the LH-RH structure is described. Eleven analogs of LH-RH (SMALLER THAN Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) have been synthesized by…”
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