Search Results - "Bedard, Sabrina"

Protein dynamics viewed by hydrogen exchange by Skinner, John J., Lim, Woon K., Bédard, Sabrina, Black, Ben E., Englander, S. Walter

“…To examine the relationship between protein structural dynamics and measurable hydrogen exchange (HX) data, the detailed exchange behavior of most of the…”
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Extending the Detection Limit in Fragment Screening of Proteins Using Reverse Micelle Encapsulation by Fuglestad, Brian, Kerstetter, Nicole E, Bédard, Sabrina, Wand, A. Joshua

“…Detection of very weak (K d > 10 mM) interactions of proteins with small molecules has been elusive. This is particularly important for fragment-based drug…”
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Protein hydrogen exchange: Testing current models by Skinner, John J., Lim, Woon K., Bédard, Sabrina, Black, Ben E., Englander, S. Walter

“…To investigate the determinants of protein hydrogen exchange (HX), HX rates of most of the backbone amide hydrogens of Staphylococcal nuclease were measured by…”
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Computational method allowing Hydrogen-Deuterium Exchange Mass Spectrometry at single amide Resolution by Gessner, Chris, Steinchen, Wieland, Bédard, Sabrina, J. Skinner, John, Woods, Virgil L., Walsh, Thomas J., Bange, Gert, Pantazatos, Dionysios P.

“…Hydrogen-deuterium exchange (HDX) coupled with mass spectrometry (HDXMS) is a rapid and effective method for localizing and determining protein stability and…”
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epigenetic mark generated by the incorporation of CENP-A into centromeric nucleosomes by Black, Ben E, Brock, Melissa A, Bédard, Sabrina, Woods, Virgil L. Jr, Cleveland, Don W

“…Mammalian centromeres are defined epigenetically. Although the physical nature of the epigenetic mark is unknown, nucleosomes in which CENP-A replaces histone…”
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Dynamic and Thermodynamic Response of the Ras Protein Cdc42Hs upon Association with the Effector Domain of PAK3 by Moorman, Veronica R., Valentine, Kathleen G., Bédard, Sabrina, Kasinath, Vignesh, Dogan, Jakob, Love, Fiona M., Wand, A. Joshua

“…Human cell division cycle protein 42 (Cdc42Hs) is a small, Rho-type guanosine triphosphatase involved in multiple cellular processes through its interactions…”
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Protein folding: Independent unrelated pathways or predetermined pathway with optional errors by Bédard, Sabrina, Krishna, Mallela M.G, Mayne, Leland, Englander, S. Walter

“…The observation of heterogeneous protein folding kinetics has been widely interpreted in terms of multiple independent unrelated pathways (IUP model), both…”
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Cytochrome c Folding Pathway: Kinetic Native-State Hydrogen Exchange by Hoang, Linh, Bédard, Sabrina, Mallela M.G. Krishna, Lin, Yan, Englander, S. Walter

“…Native-state hydrogen exchange experiments under EX1 conditions can distinguish partially unfolded intermediates by their formation rates and identify the…”
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Reverse Micelles As a Platform for Dynamic Nuclear Polarization in Solution NMR of Proteins by Valentine, Kathleen G, Mathies, Guinevere, Bédard, Sabrina, Nucci, Nathaniel V, Dodevski, Igor, Stetz, Matthew A, Can, Thach V, Griffin, Robert G, Wand, A. Joshua

“…Despite tremendous advances in recent years, solution NMR remains fundamentally restricted due to its inherent insensitivity. Dynamic nuclear polarization…”
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The Foldon Substructure of Staphylococcal Nuclease by Bédard, Sabrina, Mayne, Leland C., Peterson, Ronald W., Wand, A. Joshua, Englander, S. Walter

“…To search for submolecular foldon units, the spontaneous reversible unfolding and refolding of staphylococcal nuclease under native conditions was studied by a…”
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Characterization of Apo‐Form Selective Inhibition of Indoleamine 2,3‐Dioxygenase by Ortiz‐Meoz, Rodrigo F., Wang, Liping, Matico, Rosalie, Rutkowska‐Klute, Anna, De la Rosa, Martha, Bedard, Sabrina, Midgett, Robert, Strohmer, Katrin, Thomson, Douglas, Zhang, Cunyu, Mebrahtu, Makda, Guss, Jeffrey, Totoritis, Rachel, Consler, Thomas, Campobasso, Nino, Taylor, David, Lewis, Tia, Weaver, Kurt, Muelbaier, Marcel, Seal, John, Dunham, Richard, Kazmierski, Wieslaw, Favre, David, Bergamini, Giovanna, Shewchuk, Lisa, Rendina, Alan, Zhang, Guofeng

“…Indoleamine‐2,3‐dioxygenase 1 (IDO1) is a heme‐containing enzyme that catalyzes the rate‐limiting step in the kynurenine pathway of tryptophan (TRP)…”
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Optimization of NMR spectroscopy of encapsulated proteins dissolved in low viscosity fluids by Nucci, Nathaniel V., Marques, Bryan S., Bédard, Sabrina, Dogan, Jakob, Gledhill, John M., Moorman, Veronica R., Peterson, Ronald W., Valentine, Kathleen G., Wand, Alison L., Wand, A. Joshua

“…Comprehensive application of solution NMR spectroscopy to studies of macromolecules remains fundamentally limited by the molecular rotational correlation time…”
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Using Reverse Micelles to Extend the Detection Limit of Weak Ligand-Protein Interactions by Fuglestad, Brian, Kerstetter, Nicole E., Bed'ard, Sabrina, Wand, A. Joshua

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Nanoscale Encapsulation for Fragment Based Drug Discovery by Fuglestad, Brian, Kerstetter, Nicole E., Bédard, Sabrina, Wand, A. Joshua

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Hydrogen exchange studies of staphylococcal nuclease folding and unfolding by Bedard, Sabrina

“…We are interested in how proteins fold and why they fold the way they do. My work uses the recently developed kinetic native state hydrogen exchange method in…”
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Le pouvoir relationnel conjugal chez les femmes offrant des services de danse érotique by Bédard, Sabrina

“…Au cours des deux dernières décennies, plusieurs études se sont intéressées à évaluer le pouvoir relationnel conjugal de différents groupes de femmes dites…”
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Diffusion of hydrogen in crystalline silicon by Bedard, Sabrina, Lewis, Laurent J

“…The coefficient of diffusion of hydrogen in crystalline silicon is calculated using tight-binding molecular dynamics. Our results are in good quantitative…”
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The CENP‐A Targeting Domain (CATD) Confers Conformational Rigidity to Centromeric Nucleosomes and Plays an Essential Role at Mitosis by Black, Ben E, Jansen, Lars E T, Maddox, Paul S, Foltz, Daniel R, Brock, Melissa A, Bédard, Sabrina, Woods, Virgil, Desai, Arshad B, Shah, Jagesh V, Cleveland, Don W

“…While the physical nature of the epigenetic mark defining the location of the centromere on the chromosome is not known, nucleosomes in which CENP‐A replaces…”
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