Search Results - "Bedard, Katie L"

Discovery, SAR, and X‑ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library by Deng, Hongfeng, Zhou, Jingye, Sundersingh, Flora S, Summerfield, Jennifer, Somers, Don, Messer, Jeffrey A, Satz, Alexander L, Ancellin, Nicolas, Arico-Muendel, Christopher C, (Sargent) Bedard, Katie L, Beljean, Arthur, Belyanskaya, Svetlana L, Bingham, Ryan, Smith, Sarah E, Boursier, Eric, Carter, Paul, Centrella, Paolo A, Clark, Matthew A, Chung, Chun-wa, Davie, Christopher P, Delorey, Jennifer L, Ding, Yun, Franklin, G. Joseph, Grady, LaShadric C, Herry, Kenny, Hobbs, Clare, Kollmann, Christopher S, Morgan, Barry A, (Pothier) Kaushansky, Laura J, Zhou, Quan

“…As a potential target for obesity, human BCATm was screened against more than 14 billion DNA encoded compounds of distinct scaffolds followed by off-DNA…”
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Discovery of Highly Potent and Selective Small Molecule ADAMTS‑5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT) by Deng, Hongfeng, O’Keefe, Heather, Davie, Christopher P, Lind, Kenneth E, Acharya, Raksha A, Franklin, G. Joseph, Larkin, Jonathan, Matico, Rosalie, Neeb, Michael, Thompson, Monique M, Lohr, Thomas, Gross, Jeffrey W, Centrella, Paolo A, O’Donovan, Gary K, Bedard, Katie L. (Sargent), van Vloten, Kurt, Mataruse, Sibongile, Skinner, Steven R, Belyanskaya, Svetlana L, Carpenter, Tiffany Y, Shearer, Todd W, Clark, Matthew A, Cuozzo, John W, Arico-Muendel, Christopher C, Morgan, Barry A

“…The metalloprotease ADAMTS-5 is considered a potential target for the treatment of osteoarthritis. To identify selective inhibitors of ADAMTS-5, we employed…”
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Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor by Wu, Zining, Graybill, Todd L, Zeng, Xin, Platchek, Michael, Zhang, Jean, Bodmer, Vera Q, Wisnoski, David D, Deng, Jianghe, Coppo, Frank T, Yao, Gang, Tamburino, Alex, Scavello, Genaro, Franklin, G. Joseph, Mataruse, Sibongile, Bedard, Katie L, Ding, Yun, Chai, Jing, Summerfield, Jennifer, Centrella, Paolo A, Messer, Jeffrey A, Pope, Andrew J, Israel, David I

“…DNA-encoded small-molecule library technology has recently emerged as a new paradigm for identifying ligands against drug targets. To date, this technology has…”
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DNA-Encoded Library Hit Confirmation: Bridging the Gap Between On-DNA and Off-DNA Chemistry by Xia, Bing, Franklin, G. Joseph, Lu, Xiaojie, Bedard, Katie L, Grady, LaShadric C, Summerfield, Jennifer D, Shi, Eric X, King, Bryan W, Lind, Kenneth E, Chiu, Cynthia, Watts, Eleanor, Bodmer, Vera, Bai, Xiaopeng, Marcaurelle, Lisa A

“…DNA-encoded library (DEL) technology is a powerful platform for hit identification in academia and the pharmaceutical industry. When conducting off-DNA…”
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