Search Results - "Bedard, Karen"

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology by Bedard, Karen, Krause, Karl-Heinz

“…Biology of Ageing Laboratories, University of Geneva, Geneva, Switzerland For a long time, superoxide generation by an NADPH oxidase was considered as an…”
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NOX5: from basic biology to signaling and disease by Bedard, Karen, Jaquet, Vincent, Krause, Karl-Heinz

“…In mammals, the NADPH oxidase family of enzymes comprises seven members: NOXs 1–5, DUOX1, and DUOX2. All of these enzymes function to move an electron across…”
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NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation by Serrander, Lena, Cartier, Laetitia, Bedard, Karen, Banfi, Botond, Lardy, Bernard, Plastre, Olivier, Sienkiewicz, Andrzej, Fórró, Lászlo, Schlegel, Werner, Krause, Karl-Heinz

“…NOX4 is an enigmatic member of the NOX (NADPH oxidase) family of ROS (reactive oxygen species)-generating NADPH oxidases. NOX4 has a wide tissue distribution,…”
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Strategies for Overcoming Resistance in Tumours Harboring BRAF Mutations by Obaid, Nourah Mohammad, Bedard, Karen, Huang, Weei-Yuarn

“…The development of resistance to previously effective treatments has been a challenge for health care providers and a fear for patients undergoing cancer…”
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Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia by Bentley, Victoria L, Veinotte, Chansey J, Corkery, Dale P, Pinder, Jordan B, LeBlanc, Marissa A, Bedard, Karen, Weng, Andrew P, Berman, Jason N, Dellaire, Graham

“…Cancer therapeutics is evolving to precision medicine, with the goal of matching targeted compounds with molecular aberrations underlying a patient's cancer…”
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Germline mutations in MAP3K6 are associated with familial gastric cancer by Gaston, Daniel, Hansford, Samantha, Oliveira, Carla, Nightingale, Mathew, Pinheiro, Hugo, Macgillivray, Christine, Kaurah, Pardeep, Rideout, Andrea L, Steele, Patricia, Soares, Gabriela, Huang, Weei-Yuarn, Whitehouse, Scott, Blowers, Sarah, LeBlanc, Marissa A, Jiang, Haiyan, Greer, Wenda, Samuels, Mark E, Orr, Andrew, Fernandez, Conrad V, Majewski, Jacek, Ludman, Mark, Dyack, Sarah, Penney, Lynette S, McMaster, Christopher R, Huntsman, David, Bedard, Karen

“…Gastric cancer is among the leading causes of cancer-related deaths worldwide. While heritable forms of gastric cancer are relatively rare, identifying the…”
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Mutation in the gene encoding ubiquitin ligase LRSAM1 in patients with Charcot-Marie-Tooth disease by Guernsey, Duane L, Jiang, Haiyan, Bedard, Karen, Evans, Susan C, Ferguson, Meghan, Matsuoka, Makoto, Macgillivray, Christine, Nightingale, Mathew, Perry, Scott, Rideout, Andrea L, Orr, Andrew, Ludman, Mark, Skidmore, David L, Benstead, Timothy, Samuels, Mark E

“…Charcot-Marie-Tooth disease (CMT) represents a family of related sensorimotor neuropathies. We studied a large family from a rural eastern Canadian community,…”
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Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease by Bogdanik, Laurent P, Sleigh, James N, Tian, Cong, Samuels, Mark E, Bedard, Karen, Seburn, Kevin L, Burgess, Robert W

“…Charcot-Marie-Tooth disease (CMT) is a clinically and genetically heterogeneous condition characterized by peripheral axon degeneration with subsequent motor…”
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A novel rearrangement of occludin causes brain calcification and renal dysfunction by LeBlanc, Marissa A., Penney, Lynette S., Gaston, Daniel, Shi, Yuhao, Aberg, Erika, Nightingale, Mathew, Jiang, Haiyan, Gillett, Roxanne M., Fahiminiya, Somayyeh, Macgillivray, Christine, Wood, Ellen P., Acott, Philip D., Khan, M. Naeem, Samuels, Mark E., Majewski, Jacek, Orr, Andrew, McMaster, Christopher R., Bedard, Karen

“…Pediatric intracranial calcification may be caused by inherited or acquired factors. We describe the identification of a novel rearrangement in which a…”
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NOX4 Expression in Human Microglia Leads to Constitutive Generation of Reactive Oxygen Species and to Constitutive IL-6 Expression by Li, Bin, Bedard, Karen, Sorce, Silvia, Hinz, Boris, Dubois-Dauphin, Michel, Krause, Karl-Heinz

“…Reactive oxygen species (ROS) generation by microglia is implicated in neuroinflammation and neurotoxicity, as well as in host defense, cell proliferation and…”
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Novel splice-site mutation in ATP8B1 results in atypical Progressive Familial Intrahepatic Cholestasis Type 1 by Copeland, Emily, Renault, Nisa, Renault, Marc, Dyack, Sarah, Bulman, Dennis E, Bedard, Karen, Otley, Anthony, Magee, Fergall, Acott, Philip, Greer, Wenda L

“…Background and Aim Our objective was to identify the molecular genetic basis of an Alagille‐like condition not linked to JAG1 or NOTCH2 in two related…”
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Extensive natural variation for cellular hydrogen peroxide release is genetically controlled by Attar, Homa, Bedard, Karen, Migliavacca, Eugenia, Gagnebin, Maryline, Dupré, Yann, Descombes, Patrick, Borel, Christelle, Deutsch, Samuel, Prokisch, Holger, Meitinger, Thomas, Mehta, Divya, Wichmann, Erich, Delabar, Jean Maurice, Dermitzakis, Emmanouil T, Krause, Karl-Heinz, Antonarakis, Stylianos E

“…Natural variation in DNA sequence contributes to individual differences in quantitative traits. While multiple studies have shown genetic control over gene…”
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Challenges, Progresses, and Promises for Developing Future NADPH Oxidase Therapeutics by Bedard, Karen, Whitehouse, Scott, Jaquet, Vincent

“…NADPH oxidase (NOX) enzymes show great potential as therapeutic pharmacological targets. This Forum revolves around the roles of specific NOX isoforms in…”
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NOX family NADPH oxidases: Not just in mammals by Bedard, Karen, Lardy, Bernard, Krause, Karl-Heinz

“…NOX family NADPH oxidases are enzymes whose biological function is electron transport and the generation of reactive oxygen species (ROS). NOX enzymes in…”
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Phenotypic overlap between familial exudative vitreoretinopathy and microcephaly, lymphedema, and chorioretinal dysplasia caused by KIF11 mutations by Robitaille, Johane M, Gillett, Roxanne M, LeBlanc, Marissa A, Gaston, Daniel, Nightingale, Mathew, Mackley, Michael P, Parkash, Sandhya, Hathaway, Julie, Thomas, Aidan, Ells, Anna, Traboulsi, Elias I, Héon, Elise, Roy, Mélanie, Shalev, Stavit, Fernandez, Conrad V, MacGillivray, Christine, Wallace, Karin, Fahiminiya, Somayyeh, Majewski, Jacek, McMaster, Christopher R, Bedard, Karen

“…Retinal detachment with avascularity of the peripheral retina, typically associated with familial exudative vitreoretinopathy (FEVR), can result from mutations…”
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Editorial: Genetic mapping—the path of discovery for novel functions of the NOX NADPH oxidases by Jaquet, Vincent, Bedard, Karen

“…Discussion of the genetic basis of eosinophilia found in the Matsumoto Eosinophilia Shinshu (MES) leading to a role for p22phox, a necessary subunit of several…”
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Resveratrol, piperine and apigenin differ in their NADPH-oxidase inhibitory and reactive oxygen species-scavenging properties by Whitehouse, Scott, Chen, Pei-Lin, Greenshields, Anna L., Nightingale, Mat, Hoskin, David W., Bedard, Karen

“…Many plant-derived chemicals have been studied for their potential benefits in ailments including inflammation, cancer, neurodegeneration, and cardiovascular…”
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Autosomal dominant ApoA4 mutations present as tubulointerstitial kidney disease with medullary amyloidosis by Kmochová, Tereza, Kidd, Kendrah O, Orr, Andrew, Hnízda, Aleš, Hartmannová, Hana, Hodaňová, Kateřina, Vyleťal, Petr, Naušová, Karolína, Brinsa, Vítězslav, Trešlová, Helena, Sovová, Jana, Barešová, Veronika, Svojšová, Klára, Vrbacká, Alena, Stránecký, Viktor, Robins, Victoria C, Taylor, Abbigail, Martin, Lauren, Rivas-Chavez, Ana, Payne, Riley, Bleyer, Heidi A, Williams, Adrienne, Rennke, Helmut G, Weins, Astrid, Short, Patrick J, Agrawal, Varun, Storsley, Leroy J, Waikar, Sushrut S, McPhail, Ellen D, Dasari, Surendra, Leung, Nelson, Hewlett, Tom, Yorke, Jake, Gaston, Daniel, Geldenhuys, Laurette, Samuels, Mark, Levine, Adam P, West, Michael, Hůlková, Helena, Pompach, Petr, Novák, Petr, Weinberg, Richard B, Bedard, Karen, Živná, Martina, Sikora, Jakub, Bleyer, Sr, Anthony J, Kmoch, Stanislav

“…Sporadic cases of apolipoprotein A-IV medullary amyloidosis have been reported. Here we describe five families found to have autosomal dominant medullary…”
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NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action by Jaquet, Vincent, Marcoux, Julien, Forest, Eric, Leidal, Kevin G, McCormick, Sally, Westermaier, Yvonne, Perozzo, Remo, Plastre, Olivier, Fioraso‐Cartier, Laetitia, Diebold, Becky, Scapozza, Leonardo, Nauseef, William M, Fieschi, Franck, Krause, Karl‐Heinz, Bedard, Karen

“…BACKGROUND Celastrol is one of several bioactive compounds extracted from the medicinal plant Tripterygium wilfordii. Celastrol is used to treat inflammatory…”
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Cellular Functions of Endoplasmic Reticulum Chaperones Calreticulin, Calnexin, and ERp57 by Bedard, Karen, Szabo, Eva, Michalak, Marek, Opas, Michal

“…Glycosylated proteins destined for the cell surface or to be secreted from the cell are trafficked through the endoplasmic reticulum during synthesis and…”
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