Search Results - "Bedada, Fikru B."

Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes by Bedada, Fikru B., Wheelwright, Matthew, Metzger, Joseph M.

“…Human heart failure due to myocardial infarction is a major health concern. The paucity of organs for transplantation limits curative approaches for the…”
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Acquisition of a Quantitative, Stoichiometrically Conserved Ratiometric Marker of Maturation Status in Stem Cell-Derived Cardiac Myocytes by Bedada, Fikru B., Chan, Sunny S-K., Metzger, Stefania K., Zhang, Liying, Zhang, Jianyi, Garry, Daniel J., Kamp, Timothy J., Kyba, Michael, Metzger, Joseph M.

“…There is no consensus in the stem cell field as to what constitutes the mature cardiac myocyte. Thus, helping formalize a molecular signature for cardiac…”
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Inducing positive inotropy in human iPSC-derived cardiac muscle by gene editing-based activation of the cardiac α-myosin heavy chain by Bedada, Fikru B., Thompson, Brian R., Mikkila, Jennifer L., Chan, Sunny S.-K., Choi, Si Ho, Toso, Erik A., Kyba, Michael, Metzger, Joseph M.

“…Human induced pluripotent stem cells and their differentiation into cardiac myocytes (hiPSC-CMs) provides a unique and valuable platform for studies of cardiac…”
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Aerobic Exercise Training-Induced Changes on DNA Methylation in Mild Cognitively Impaired Elderly African Americans: Gene, Exercise, and Memory Study - GEMS-I by Ngwa, Julius S, Nwulia, Evaristus, Ntekim, Oyonumo, Bedada, Fikru B, Kwabi-Addo, Bernard, Nadarajah, Sheeba, Johnson, Steven, Southerland, William M, Kwagyan, John, Obisesan, Thomas O

“…DNA methylation at CpG sites is a vital epigenetic modification of the human genome affecting gene expression, and potentially, health outcomes. However,…”
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Exercise Training-Increased FBXO32 and FOXO1 in a Gender-Dependent Manner in Mild Cognitively Impaired African Americans: GEMS-1 Study by Bedada, Fikru B, Ntekim, Oyonumo E, Nwulia, Evaristus O, Fungwe, Thomas V, Nadarajah, Sheeba Raaj, Obisesan, Thomas O

“…The ubiquitin proteasome system (UPS) and transcription factors play a pivotal role in cellular clearance and minimizing the accumulation of Aβ in…”
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Severe dystrophic cardiomyopathy caused by the enteroviral protease 2A-mediated C-terminal dystrophin cleavage fragment by Barnabei, Matthew S, Sjaastad, Frances V, Townsend, DeWayne, Bedada, Fikru B, Metzger, Joseph M

“…Enterovirus infection can cause severe cardiomyopathy in humans. The virus-encoded 2A protease is known to cleave the cytoskeletal protein dystrophin. It is…”
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Insight into genomic organization of pathogenic coronaviruses, SARS-CoV-2: Implication for emergence of new variants, laboratory diagnosis and treatment options by Bedada, Fikru B, Gorfu, Gezahegn, Teng, Shaolei, Neita, Marguerite E

“…SARS-CoV-2 is a novel zoonotic positive-sense RNA virus (ssRNA+) belonging to the genus beta coronaviruses (CoVs) in the Coronaviridae family. It is the…”
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Advancing physiological maturation in human induced pluripotent stem cell‐derived cardiac muscle by gene editing an inducible adult troponin isoform switch by Wheelwright, Matthew, Mikkila, Jennifer, Bedada, Fikru B., Mandegar, Mohammad A., Thompson, Brian R., Metzger, Joseph M.

“…Advancing maturation of stem cell‐derived cardiac muscle represents a major barrier to progress in cardiac regenerative medicine. Cardiac muscle maturation…”
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Artificial selection for whole animal low intrinsic aerobic capacity co-segregates with hypoxia-induced cardiac pump failure by Palpant, Nathan J, Szatkowski, Michael L, Wang, Wang, Townsend, DeWayne, Bedada, Fikru B, Koch, Lauren G, Britton, Steven L, Metzger, Joseph M

“…Oxygen metabolism is a strong predictor of the general health and fitness of an organism. In this study, we hypothesized that a divergence in intrinsic aerobic…”
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Mesenchymal stem cells attenuate inflammatory processes in the heart and lung via inhibition of TNF signaling by Martire, Alessandra, Bedada, Fikru B., Uchida, Shizuka, Pöling, Jochen, Krüger, Marcus, Warnecke, Henning, Richter, Manfred, Kubin, Thomas, Herold, Susanne, Braun, Thomas

“…Mesenchymal stem cells (MSC) have been used to treat different clinical conditions although the mechanisms by which pathogenetic processes are affected are…”
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Systolic Blood Pressure Is Associated with Increased Brain Amyloid Load in Mild Cognitively Impaired Participants: Alzheimer's Disease Neuroimaging Initiatives Study by Fungwe, Thomas V, Ngwa, Julius S, Johnson, Steven P, Turner, Jilian V, Ramirez Ruiz, Mara I, Ogunlana, Oludolapo O, Bedada, Fikru B, Nadarajah, Sheeba, Ntekim, Oyonumo E, Obisesan, Thomas O

“…Cardiovascular disease (CVD), including elevated blood pressure (BP), is known to promote Alzheimer's disease (AD) risk. Although brain amyloid load is a…”
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Molecular inotropy mediated by cardiac miR-based PDE4D/PRKAR1α/phosphoprotein signaling by Bedada, Fikru B., Martindale, Joshua J., Arden, Erik, Metzger, Joseph M.

“…Molecular inotropy refers to cardiac contractility that can be modified to affect overall heart pump performance. Here we show evidence of a new molecular…”
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Cardiac disease in mucopolysaccharidosis type I attributed to catecholaminergic and hemodynamic deficiencies by Palpant, Nathan J, Bedada, Fikru B, Peacock, Brandon, Blazar, Bruce R, Metzger, Joseph M, Tolar, Jakub

“…Cardiac dysfunction is a common cause of death among pediatric patients with mutations in the lysosomal hydrolase α-l-iduronidase (IDUA) gene, which causes…”
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Advancing physiological maturation in human iPSC-derived cardiac muscle by gene editing an inducible adult troponin isoform switch by Wheelwright, Matthew, Mikkila, Jennifer, Bedada, Fikru B., Mandegar, Mohammad A., Thompson, Brian R., Metzger, Joseph M.

“…Advancing maturation of stem cell-derived cardiac muscle represents a major barrier to progress in cardiac regenerative medicine. Cardiac muscle maturation…”
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P3‐190: FBXO32 AND FOXO1 ARE COORDINATELY EXPRESSED IN A ONE‐TO‐ONE STOICHIOMETRIC PATTERN AT BASELINE, DURING EXERCISE AND IN BOTH GENDERS IN ELDERLY AFRICAN AMERICANS WITH MCI by Bedada, Fikru B., Ntekim, Oyonumo, Fungwe, Thomas V., Ngwa, Julius S., Obisesan, Thomas O.

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Exercise intervention differentially induces the expression of cystathionine beta synthase (CBS) in African American with MCI: Implication for endogenous H2S generation and component of aging pathway by Bedada, Fikru B., Ntekim, Oyonumo, Johnson, Steven P., Turner, Jillian, Nadarajah, Sheeba R., Ngwa, Julius S., Bond, Vernon, Kwagyan, John, Obisesan, Thomas O.

“…Background Decline in metabolic fitness, accumulation of undesirable metabolic changes and cellular senescence are the hallmarks of aging [1,2]. The…”
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Exercise intervention differentially induces the expression of cystathionine beta synthase (CBS) in African American with MCI: Implication for endogenous H 2 S generation and component of aging pathway: Human neuropathology/amyloid by Bedada, Fikru B., Ntekim, Oyonumo, Johnson, Steven P., Turner, Jillian, Nadarajah, Sheeba R., Ngwa, Julius S., Bond, Vernon, Kwagyan, John, Obisesan, Thomas O.

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miR-208A Targeted Suppression of PDE4D Directly Enhances Myocyte Contractile Function via PKA-Mediated Phosphorylation of cTnI and PLN by Bedada, Fikru B., Metzger, Joseph M.

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FBXO32 AND FOXO1 ARE COORDINATELY EXPRESSED IN A ONE-TO-ONE STOICHIOMETRIC PATTERN AT BASELINE, DURING EXERCISE AND IN BOTH GENDERS IN ELDERLY AFRICAN AMERICANS WITH MCI by Bedada, Fikru B., Ntekim, Oyonumo, Fungwe, Thomas V., Ngwa, Julius S., Obisesan, Thomas O.

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P3‐190: FBXO32 AND FOXO1 ARE COORDINATELY EXPRESSED IN A ONE‐TO‐ONE STOICHIOMETRIC PATTERN AT BASELINE, DURING EXERCISE AND IN BOTH GENDERS IN ELDERLY AFRICAN AMERICANS WITH MCI by Bedada, Fikru B., Ntekim, Oyonumo, Fungwe, Thomas V., Ngwa, Julius S., Obisesan, Thomas O.

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