Search Results - "Becuwe, Michel"

Lipid droplets and liver disease: from basic biology to clinical implications by Gluchowski, Nina L., Becuwe, Michel, Walther, Tobias C., Farese, Robert V.

“…Key Points Depending on the body's needs, the liver utilizes lipids to generate metabolic energy, secretes them as lipoproteins, or packages them for storage…”
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Integrated control of transporter endocytosis and recycling by the arrestin-related protein Rod1 and the ubiquitin ligase Rsp5 by Becuwe, Michel, Léon, Sébastien

“…After endocytosis, membrane proteins can recycle to the cell membrane or be degraded in lysosomes. Cargo ubiquitylation favors their lysosomal targeting and…”
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Seipin is required for converting nascent to mature lipid droplets by Wang, Huajin, Becuwe, Michel, Housden, Benjamin E, Chitraju, Chandramohan, Porras, Ashley J, Graham, Morven M, Liu, Xinran N, Thiam, Abdou Rachid, Savage, David B, Agarwal, Anil K, Garg, Abhimanyu, Olarte, Maria-Jesus, Lin, Qingqing, Fröhlich, Florian, Hannibal-Bach, Hans Kristian, Upadhyayula, Srigokul, Perrimon, Norbert, Kirchhausen, Tomas, Ejsing, Christer S, Walther, Tobias C, Farese, Robert V

“…How proteins control the biogenesis of cellular lipid droplets (LDs) is poorly understood. Using and human cells, we show here that seipin, an ER protein…”
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Chromosomal rearrangements maintain a polymorphic supergene controlling butterfly mimicry by Joron, Mathieu, Frezal, Lise, Jones, Robert T., Chamberlain, Nicola L., Lee, Siu F., Haag, Christoph R., Whibley, Annabel, Becuwe, Michel, Baxter, Simon W., Ferguson, Laura, Wilkinson, Paul A., Salazar, Camilo, Davidson, Claire, Clark, Richard, Quail, Michael A., Beasley, Helen, Glithero, Rebecca, Lloyd, Christine, Sims, Sarah, Jones, Matthew C., Rogers, Jane, Jiggins, Chris D., ffrench-Constant, Richard H.

“…Evolution of supergenes The toxic butterfly Heliconius numata , found in forests across South America, mimics the wing patterns of several species of another…”
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The yeast arrestin-related protein Bul1 is a novel actor of glucose-induced endocytosis by Hovsepian, Junie, Albanèse, Véronique, Becuwe, Michel, Ivashov, Vasyl, Teis, David, Léon, Sébastien

“…Yeast cells have a remarkable ability to adapt to nutritional changes in their environment. During adaptation, nutrient-signaling pathways drive the selective…”
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FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis by Becuwe, Michel, Bond, Laura M, Pinto, Antonio F M, Boland, Sebastian, Mejhert, Niklas, Elliott, Shane D, Cicconet, Marcelo, Graham, Morven M, Liu, Xinran N, Ilkayeva, Olga, Saghatelian, Alan, Walther, Tobias C, Farese, Jr, Robert V

“…The endoplasmic reticulum is a cellular hub of lipid metabolism, coordinating lipid synthesis with continuous changes in metabolic flux. Maintaining ER lipid…”
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A molecular switch on an arrestin-like protein relays glucose signaling to transporter endocytosis by Becuwe, Michel, Vieira, Neide, Lara, David, Gomes-Rezende, Jéssica, Soares-Cunha, Carina, Casal, Margarida, Haguenauer-Tsapis, Rosine, Vincent, Olivier, Paiva, Sandra, Léon, Sébastien

“…Endocytosis regulates the plasma membrane protein landscape in response to environmental cues. In yeast, the endocytosis of transporters depends on their…”
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Ubiquitin-Mediated Regulation of Endocytosis by Proteins of the Arrestin Family by Becuwe, Michel, Herrador, Antonio, Haguenauer-Tsapis, Rosine, Vincent, Olivier, Léon, Sébastien

“…In metazoans, proteins of the arrestin family are key players of G-protein-coupled receptors (GPCRS) signaling and trafficking. Following stimulation,…”
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Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment by Fanning, Saranna, Haque, Aftabul, Imberdis, Thibaut, Baru, Valeriya, Barrasa, M. Inmaculada, Nuber, Silke, Termine, Daniel, Ramalingam, Nagendran, Ho, Gary P.H., Noble, Tallie, Sandoe, Jackson, Lou, Yali, Landgraf, Dirk, Freyzon, Yelena, Newby, Gregory, Soldner, Frank, Terry-Kantor, Elizabeth, Kim, Tae-Eun, Hofbauer, Harald F., Becuwe, Michel, Jaenisch, Rudolf, Pincus, David, Clish, Clary B., Walther, Tobias C., Farese, Robert V., Srinivasan, Supriya, Welte, Michael A., Kohlwein, Sepp D., Dettmer, Ulf, Lindquist, Susan, Selkoe, Dennis

“…In Parkinson’s disease (PD), α-synuclein (αS) pathologically impacts the brain, a highly lipid-rich organ. We investigated how alterations in αS or…”
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Casein kinase 1 controls the activation threshold of an α-arrestin by multisite phosphorylation of the interdomain hinge by Herrador, Antonio, Livas, Daniela, Soletto, Lucía, Becuwe, Michel, Léon, Sébastien, Vincent, Olivier

“…α-Arrestins play a key role as trafficking adaptors in both yeast and mammals. The yeast Rim8/Art9 α-arrestin mediates the recruitment of endosomal sorting…”
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Combined immunodeficiency due to a mutation in the γ1 subunit of the coat protein I complex by Bainter, Wayne, Platt, Craig D, Park, Seung-Yeol, Stafstrom, Kelsey, Wallace, Jacqueline G, Peters, Zachary T, Massaad, Michel J, Becuwe, Michel, Salinas, Sandra Andrea, Jones, Jennifer, Beaussant-Cohen, Sarah, Jaber, Faris, Yang, Jia-Shu, Walther, Tobias C, Orange, Jordan S, Rao, Chitong, Rakoff-Nahoum, Seth, Tsokos, Maria, Naseem, Shafiq Ur Rehman, Al-Tamemi, Salem, Chou, Janet, Hsu, Victor W, Geha, Raif S

“…The coat protein I (COPI) complex mediates retrograde trafficking from the Golgi to the endoplasmic reticulum (ER). Five siblings with persistent bacterial and…”
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Combined immunodeficiency due to a mutation in the [gamma]1 subunit of the coat protein I complex by Bainter, Wayne, Platt, Craig D, Park, Seung-Yeol, Stafstrom, Kelsey, Wallace, Jacqueline G, Peters, Zachary T, Massaad, Michel J, Becuwe, Michel, Salinas, Sandra Andrea, Jones, Jennifer, Beaussant-Cohen, Sarah, Jaber, Faris, Yang, Jia-Shu, Walther, Tobias C, Orange, Jordan S, Rao, Chitong, Rakoff-Nahoum, Seth, Tsokos, Maria, Naseem, Shafiq Ur Rehman, Al-Tamemi, Salem, Chou, Janet, Hsu, Victor W, Geha, Raif S

“…The coat protein I (COPI) complex mediates retrograde trafficking from the Golgi to the endoplasmic reticulum (ER). Five siblings with persistent bacterial and…”
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Studying Protein Ubiquitylation in Yeast by Hovsepian, Junie, Becuwe, Michel, Kleifeld, Oded, Glickman, Michael H, Léon, Sébastien

“…Ubiquitylation is a reversible posttranslational modification that is critical for most, if not all, cellular processes and essential for viability. Ubiquitin…”
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