Search Results - "Becraft, Jacob"

In Vivo Validation of a Reversible Small Molecule-Based Switch for Synthetic Self-Amplifying mRNA Regulation by Mc Cafferty, Sean, De Temmerman, Joyca, Kitada, Tasuku, Becraft, Jacob R., Weiss, Ron, Irvine, Darrell J., Devreese, Mathias, De Baere, Siegrid, Combes, Francis, Sanders, Niek N.

“…Synthetic mRNA therapeutics have the potential to revolutionize healthcare, as they enable patients to produce therapeutic proteins inside their own bodies…”
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Small-molecule-based regulation of RNA-delivered circuits in mammalian cells by Wagner, Tyler E., Becraft, Jacob R., Bodner, Katie, Teague, Brian, Zhang, Xin, Woo, Amanda, Porter, Ely, Alburquerque, Bremy, Dobosh, Brian, Andries, Oliwia, Sanders, Niek N., Beal, Jacob, Densmore, Douglas, Kitada, Tasuku, Weiss, Ron

“…Synthetic mRNA is an attractive vehicle for gene therapies because of its transient nature and improved safety profile over DNA. However, unlike DNA, broadly…”
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Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis by Kim, YongTae, Lobatto, Mark E., Kawahara, Tomohiro, Chung, Bomy Lee, Mieszawska, Aneta J., Sanchez-Gaytan, Brenda L., Fay, Francois, Senders, Max L., Calcagno, Claudia, Becraft, Jacob, Saung, May Tun, Gordon, Ronald E., Stroes, Erik S. G., Ma, Mingming, Farokhzad, Omid C., Fayad, Zahi A., Mulder, Willem J. M., Langer, Robert

“…Therapeutic and diagnostic nanomaterials are being intensely studied for several diseases, including cancer and atherosclerosis. However, the exact mechanism…”
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The effect of glycosaminoglycan content on polyethylenimine-based gene delivery within three-dimensional collagen-GAG scaffolds by Hortensius, Rebecca A, Becraft, Jacob R, Pack, Daniel W, Harley, Brendan A C

“…The design of biomaterials for increasingly complex tissue engineering applications often requires exogenous presentation of biomolecular signals. Integration…”
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Litter Breakdown and Benthic Invertebrate Detritivores from a Hydrologically Restored Stream by Becraft, Jacob

“…The breakdown of coarse forms of detritus into finer forms is an ecosystem function of forested headwater streams. Many factors influence the rate of litter…”
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Nanomedicines for endothelial disorders by Lee Chung, Bomy, Toth, Michael J., Kamaly, Nazila, Sei, Yoshitaka J., Becraft, Jacob, Mulder, Willem J.M., Fayad, Zahi A., Farokhzad, Omid C., Kim, YongTae, Langer, Robert

“…•We review the key features of a functioning and a malfunctioning endothelium.•We highlight endothelial pathologies in asthma, burns, heart failure, and…”
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Supporting US public health experts by Cohen, Ron, Francois, Cedric, Crowley, John, Hastings, Paul, King, Rachel, Love, Ted W., Maraganore, John, McMurry-Heath, Michelle, Levin, Jeremy

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Author Correction: Supporting US public health experts by Cohen, Ron, Francois, Cedric, Crowley, John, Hastings, Paul, King, Rachel, Love, Ted W., Maraganore, John, McMurry-Heath, Michelle, Levin, Jeremy

“…A Correction to this paper has been published: https://doi.org/10.1038/s41587-020-00792-5…”
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Abstract 2731: STX-001, a locally administered LNP-formulated self-replicating mRNA that encodes the therapeutic payload IL-12, induces deep systemic immune responses to solid tumors by Sowell, Ryan T., Khurana, Jaspreet S., Su, Zhijun, Zhao, Weiyu, Shenoy, Gautam N., Dey, Madhuri, Lemaire, Alexander C., Simon, Anna J., Njiru, Ashley G., Patenaude, Ryan A., DiMarzio, Britt A., Dzurko, Daniel T., Gately, Daniel W., Coia, Aidan B., Abraham, Wuhbet D., Quiñones, Julian, Shah, Aalok, Barberio, Joseph L., Nambiar, Prashant R., Becraft, Jacob R., Kitada, Tasuku

“…Abstract Critical advances in immunotherapies have expanded treatment options and improved patient outcomes across many solid tumor indications. However,…”
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