Search Results - "Becq, Hélène"

The conversion of glutamate by glutamine synthase in neocortical astrocytes from juvenile rat is important to limit glutamate spillover and peri/extrasynaptic activation of NMDA receptors by Trabelsi, Yosra, Amri, Mohamed, Becq, Hélène, Molinari, Florence, Aniksztejn, Laurent

“…Glutamate transporters (EAATs) are important to maintain spatial and temporal specificity of synaptic transmission. Their efficiency to uptake and transport…”
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A Kv7.2 mutation associated with early onset epileptic encephalopathy with suppression‐burst enhances Kv7/M channel activity by Devaux, Jérôme, Abidi, Affef, Roubertie, Agathe, Molinari, Florence, Becq, Hélène, Lacoste, Caroline, Villard, Laurent, Milh, Mathieu, Aniksztejn, Laurent

“…Summary Mutations in the KCNQ2 gene encoding the voltage‐gated potassium channel subunit Kv7.2 cause early onset epileptic encephalopathy (EOEE). Most…”
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A recurrent KCNQ2 pore mutation causing early onset epileptic encephalopathy has a moderate effect on M current but alters subcellular localization of Kv7 channels by Abidi, Affef, Devaux, Jérôme J, Molinari, Florence, Alcaraz, Gisèle, Michon, François-Xavier, Sutera-Sardo, Julie, Becq, Hélène, Lacoste, Caroline, Altuzarra, Cécilia, Afenjar, Alexandra, Mignot, Cyril, Doummar, Diane, Isidor, Bertrand, Guyen, Sylvie N, Colin, Estelle, De La Vaissière, Sabine, Haye, Damien, Trauffler, Adeline, Badens, Catherine, Prieur, Fabienne, Lesca, Gaetan, Villard, Laurent, Milh, Mathieu, Aniksztejn, Laurent

“…Abstract Mutations in the KCNQ2 gene encoding the voltage-dependent potassium M channel Kv7.2 subunit cause either benign epilepsy or early onset epileptic…”
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Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival by Pellegrino, Christophe, Gubkina, Olena, Schaefer, Michael, Becq, Hélène, Ludwig, Anastasia, Mukhtarov, Marat, Chudotvorova, Ilona, Corby, Severine, Salyha, Yuriy, Salozhin, Sergey, Bregestovski, Piotr, Medina, Igor

“…Non‐technical summary  ‘To be, or not to be’– thousands of neurons are facing this Shakespearean question in the brains of patients suffering from epilepsy or…”
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The Epilepsy of Infancy With Migrating Focal Seizures: Identification of de novo Mutations of the KCNT2 Gene That Exert Inhibitory Effects on the Corresponding Heteromeric KNa1.1/KNa1.2 Potassium Channel by Mao, Xiao, Bruneau, Nadine, Gao, Quwen, Becq, Hélène, Jia, Zhengjun, Xi, Hui, Shu, Li, Wang, Hua, Szepetowski, Pierre, Aniksztejn, Laurent

“…Epilepsy of Infancy with Migrating Focal Seizures (EIMFS) (previously called Malignant migrating partial seizures of infancy) are early-onset epileptic…”
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A possible link between KCNQ2‐ and STXBP1‐related encephalopathies: STXBP1 reduces the inhibitory impact of syntaxin‐1A on M current by Devaux, Jérôme, Dhifallah, Sandra, De Maria, Michela, Stuart‐Lopez, Geoffrey, Becq, Hélène, Milh, Mathieu, Molinari, Florence, Aniksztejn, Laurent

“…Summary Objective Kv7 channels mediate the voltage‐gated M‐type potassium current. Reduction of M current due to KCNQ2 mutations causes early onset epileptic…”
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Inhibition of Glutamate Transporters Results in a “Suppression‐Burst” Pattern and Partial Seizures in the Newborn Rat by Milh, Mathieu, Becq, Hélène, Villeneuve, Nathalie, Ben‐Ari, Yehezkel, Aniksztejn, Laurent

“…Purpose: To determine the electrophysiological pattern and propose a clinical relevance of a deficient glutamate transport in the developing brain. Methods:…”
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Time‐limited alterations in cortical activity of a knock‐in mouse model of KCNQ2‐related developmental and epileptic encephalopathy by Biba‐Maazou, Najoua, Becq, Hélène, Pallesi‐Pocachard, Emilie, Sarno, Stefania, Granjeaud, Samuel, Montheil, Aurélie, Kurz, Marie, Villard, Laurent, Milh, Mathieu, Santini, Pierre‐Pascal Lenck, Aniksztejn, Laurent

“…De novo missense variants in the KCNQ2 gene encoding the Kv7.2 subunit of voltage‐gated potassium Kv7/M channels are the main cause of developmental and…”
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Inhibition of the Mitochondrial Glutamate Carrier SLC25A22 in Astrocytes Leads to Intracellular Glutamate Accumulation by Goubert, Emmanuelle, Mircheva, Yanina, Lasorsa, Francesco M, Melon, Christophe, Profilo, Emanuela, Sutera, Julie, Becq, Hélène, Palmieri, Ferdinando, Palmieri, Luigi, Aniksztejn, Laurent, Molinari, Florence

“…The solute carrier family 25 (SLC25) drives the import of a large diversity of metabolites into mitochondria, a key cellular structure involved in many…”
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An epilepsy-related ARX polyalanine expansion modifies glutamatergic neurons excitability and morphology without affecting GABAergic neurons development by Beguin, Shirley, Crépel, Valérie, Aniksztejn, Laurent, Becq, Hélène, Pelosi, Barbara, Pallesi-Pocachard, Emilie, Bouamrane, Lamine, Pasqualetti, Massimo, Kitamura, Kunio, Cardoso, Carlos, Represa, Alfonso

“…Epileptic encephalopathies comprise a heterogeneous group of severe infantile disorders for which the pathophysiological basis of epilepsy is inaccurately…”
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Dynamic changes in interneuron morphophysiological properties mark the maturation of hippocampal network activity by Allene, Camille, Picardo, Michel A, Becq, Hélène, Miyoshi, Goichi, Fishell, Gord, Cossart, Rosa

“…During early postnatal development, neuronal networks successively produce various forms of spontaneous patterned activity that provide key signals for circuit…”
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Abnormal Network Activity in a Targeted Genetic Model of Human Double Cortex by Ackman, James B, Aniksztejn, Laurent, Crepel, Valerie, Becq, Helene, Pellegrino, Christophe, Cardoso, Carlos, Ben-Ari, Yehezkel, Represa, Alfonso

“…In human patients, cortical dysplasia produced by Doublecortin (DCX) mutations lead to mental retardation and intractable infantile epilepsies, but the…”
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Spontaneous Epileptic Manifestations in a DCX Knockdown Model of Human Double Cortex by Lapray, Damien, Popova, Irina Y., Kindler, Jennifer, Jorquera, Isabel, Becq, Hélène, Manent, Jean-Bernard, Luhmann, Heiko J., Represa, Alfonso

“…Previous reports indicate that in utero knockdown of doublecortin (DCX) results in the genesis of a subcortical heterotopia reminiscent of the doublecortex…”
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Paracrine intercellular communication by a Ca2+- and SNARE-independent release of GABA and glutamate prior to synapse formation by Demarque, Michael, Represa, Alfonso, Becq, Hélène, Khalilov, Ilgam, Ben-Ari, Yehezkel, Aniksztejn, Laurent

“…GABA and glutamate receptors are expressed in immature "silent" CA1 pyramidal neurons prior to synapse formation, but their function is unknown. We now report…”
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Glutamate Transporters Prevent the Generation of Seizures in the Developing Rat Neocortex by Demarque, Michael, Villeneuve, Nathalie, Manent, Jean-Bernard, Becq, Helene, Represa, Alfonso, Ben-Ari, Yehezkel, Aniksztejn, Laurent

“…Glutamate transporters are operative at an early developmental stage well before synapse formation, but their functional significance has not been determined…”
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The conversion of glutamate by glutamine synthase in neocortical astrocytes from juvenile rat is important to limit glutamate spillover and peri/extrasynaptic activation of NMDA receptors: GS Inhibition Reduces EAATs Efficiency by Trabelsi, Yosra, Amri, Mohamed, Becq, Hélène, Molinari, Florence, Aniksztejn, Laurent

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A possible link between KCNQ 2 ‐ and STXBP 1 ‐related encephalopathies: STXBP 1 reduces the inhibitory impact of syntaxin‐1A on M current by Devaux, Jérôme, Dhifallah, Sandra, De Maria, Michela, Stuart‐Lopez, Geoffrey, Becq, Hélène, Milh, Mathieu, Molinari, Florence, Aniksztejn, Laurent

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The Epilepsy of Infancy With Migrating Focal Seizures: Identification of de novo Mutations of the KCNT2 Gene That Exert Inhibitory Effects on the Corresponding Heteromeric K Na 1.1/K Na 1.2 Potassium Channel by Mao, Xiao, Bruneau, Nadine, Gao, Quwen, Becq, Hélène, Jia, Zhengjun, Xi, Hui, Shu, Li, Wang, Hua, Szepetowski, Pierre, Aniksztejn, Laurent

“…The epilepsy of infancy with migrating focal seizures (EIMFS; previously called Malignant migrating partial seizures of infancy) are early-onset epileptic…”
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Paracrine Intercellular Communication by a Ca 2+- and SNARE-Independent Release of GABA and Glutamate Prior to Synapse Formation by Demarque, Michael, Represa, Alfonso, Becq, Hélène, Khalilov, Ilgam, Ben-Ari, Yehezkel, Aniksztejn, Laurent

“…GABA and glutamate receptors are expressed in immature “silent” CA1 pyramidal neurons prior to synapse formation, but their function is unknown. We now report…”
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Quantal Release of Glutamate Generates Pure Kainate and Mixed AMPA/Kainate EPSCs in Hippocampal Neurons by Cossart, Rosa, Epsztein, Jérôme, Tyzio, Roman, Becq, Hélène, Hirsch, June, Ben-Ari, Yehezkel, Crépel, Valérie

“…The relative contribution of kainate receptors to ongoing glutamatergic activity is at present unknown. We report the presence of spontaneous, miniature, and…”
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