Search Results - "Beckmann, MP"

Cloning of the human homologue of the murine flt3 ligand : a growth factor for early hematopoietic progenitor cells by LYMAN, S. D, JAMES, L, JOHNSON, L, BRASEL, K, DE VRIES, P, ESCOBAR, S. S, DOWNEY, H, SPLETT, R. R, BECKMANN, M. P, MCKENNA, H. J

“…Using a fragment of the murine flt3 ligand as a probe, we have succeeded in cloning a human flt3 ligand from a human T-cell lambda gt10 cDNA library. The human…”
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Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells by Lyman, S D, James, L, Vanden Bos, T, de Vries, P, Brasel, K, Gliniak, B, Hollingsworth, L T, Picha, K S, McKenna, H J, Splett, R R

“…Cloning of a ligand for the murine flt3/flk-2 tyrosine kinase receptor was undertaken using a soluble form of the receptor to identify a source of ligand. A…”
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Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation by Hintzen, RQ, Lens, SM, Lammers, K, Kuiper, H, Beckmann, MP, van Lier, RA

“…Molecules of the TNF-R family have been shown to be essential in the regulation of lymphocyte growth and differentiation. The TNF-R family member CD27 binds to…”
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A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins by Smith, Craig A., Davis, Terri, Anderson, Dirk, Solam, Lisabeth, Beckmann, M. Patricia, Jerzy, Rita, Dower, Steven K., Cosman, David, Goodwin, Raymond G.

“…Tumor necrosis factor α and β (TNF-α and TNF-β bind surface receptors on a variety of cell types to mediate a wide range of immunological responses,…”
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Leukemia inhibitory factor receptor is structurally related to the IL‐6 signal transducer, gp130 by Gearing, D.P., Thut, C.J., VandeBos, T., Gimpel, S.D., Delaney, P.B., King, J., Price, V., Cosman, D., Beckmann, M.P.

“…Leukemia inhibitory factor (LIF) is a cytokine with a broad range of activities that in many cases parallel those of interleukin‐6 (IL‐6) although LIF and IL‐6…”
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A new cytokine receptor superfamily by Cosman, D, Lyman, S D, Idzerda, R L, Beckmann, M P, Park, L S, Goodwin, R G, March, C J

“…The amino acid sequences of several, recently cloned cytokine receptors show significant homologies, primarily in their extracellular, ligand-binding domains…”
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Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. Interacting effects involving suppression, synergistic suppression, and blocking of suppression by Broxmeyer, HE, Sherry, B, Cooper, S, Lu, L, Maze, R, Beckmann, MP, Cerami, A, Ralph, P

“…Macrophage inflammatory protein (MIP)-1 alpha, part of a family termed chemokines, has been implicated in suppression of hemopoietic stem and progenitor cell…”
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Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis by Sempowski, GD, Beckmann, MP, Derdak, S, Phipps, RP

“…The purpose of this study was to determine whether or not membrane-bound and soluble forms of IL-4 receptors are expressed by isolated subsets of murine lung…”
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The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms by Mosley, B, Beckmann, M P, March, C J, Idzerda, R L, Gimpel, S D, VandenBos, T, Friend, D, Alpert, A, Anderson, D, Jackson, J

“…Receptors for interleukin-4 (IL-4) are expressed at low levels on a wide variety of primary cells and cultured cell lines. Fluorescence-activated sorting of…”
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Characterization of the human CD27 ligand, a novel member of the TNF gene family by Hintzen, RQ, Lens, SM, Beckmann, MP, Goodwin, RG, Lynch, D, van Lier, RA

“…CD27 is a lymphocyte-specific member of the TNF/NGF-R family that is highly induced on T cells after TCR stimulation, primarily on lymphocytes belonging to the…”
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Molecular characterization of a family of ligands for eph‐related tyrosine kinase receptors by Beckmann, M.P., Cerretti, D.P., Baum, P., Vanden Bos, T., James, L., Farrah, T., Kozlosky, C., Hollingsworth, T., Shilling, H., Maraskovsky, E.

“…A family of tyrosine kinase receptors related to the product of the eph gene has been described recently. One of these receptors, elk, has been shown to be…”
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Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily by Idzerda, R L, March, C J, Mosley, B, Lyman, S D, Vanden Bos, T, Gimpel, S D, Din, W S, Grabstein, K H, Widmer, M B, Park, L S

“…IL-4, a pleiotropic cytokine produced by T lymphocytes, plays an important role in immune responsiveness by regulating proliferation and differentiation of a…”
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Importance of the amino terminus of the interleukin-8 receptor in ligand interactions by R B Gayle, 3rd, P R Sleath, S Srinivason, C W Birks, K S Weerawarna, D P Cerretti, C J Kozlosky, N Nelson, T Vanden Bos, M P Beckmann

“…Interleukin-8 (IL-8) and growth regulatory gene/melanoma growth stimulatory activity (GRO/MGSA) are small polypeptide molecules involved in the chemotactic…”
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Characterization of the protein encoded by the flt3 (flk2) receptor-like tyrosine kinase gene by Lyman, S D, James, L, Zappone, J, Sleath, P R, Beckmann, M P, Bird, T

“…We have developed rabbit polyclonal antibodies to the C-terminus of the flt3-encoded protein, which is a member of the receptor tyrosine kinase family…”
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Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins by Kozlosky, C J, Maraskovsky, E, McGrew, J T, VandenBos, T, Teepe, M, Lyman, S D, Srinivasan, S, Fletcher, F A, Gayle, 3rd, R B, Cerretti, D P

“…Hek is a member of the eph subfamily of receptor tyrosine kinases whose members include elk, hek2, sek, eph and eck among others. Using a soluble form of hek…”
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Role of CD27 in T cell immune response. Analysis by recombinant soluble CD27 by Agematsu, K, Kobata, T, Sugita, K, Freeman, GJ, Beckmann, MP, Schlossman, SF, Morimoto, C

“…CD27 is a disulfide-linked 120-kDa transmembrane glycoprotein expressed on the majority of T cells, B cells, and NK cells; it has homology to a family of…”
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Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2 by Cerretti, D P, Kozlosky, C J, Vanden Bos, T, Nelson, N, Gearing, D P, Beckmann, M P

“…Interleukin-8 (IL-8), neutrophil activating peptide-2 (NAP-2), and growth regulated gene (GRO, also known as melanoma growth stimulatory activity) are members…”
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Comparison of Biological Properties and Transforming Potential of Human PDGF-A and PDGF-B Chains by Beckmann, M. Patricia, Betsholtz, Christer, Heldin, Carl-Henrik, Westermark, Bengt, Di Marco, Eddi, Di Fiore, Pier Paolo, Robbins, Keith C., Aaronson, Stuart A.

“…Human platelet-derived growth factor (PDGF) consists of two distinct but related polypeptide chains designated PDGF-A and PDGF-B. The gene encoding PDGF-B has…”
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Regulation of alloreactivity in vivo by IL-4 and the soluble IL-4 receptor by Fanslow, WC, Clifford, KN, Park, LS, Rubin, AS, Voice, RF, Beckmann, MP, Widmer, MB

“…Although numerous in vitro studies have demonstrated that cytokines are involved in the generation of alloreactive effector cells, the role of these regulatory…”
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Cytokine receptors and B cell functions. I. Recombinant soluble receptors specifically inhibit IL-1- and IL-4-induced B cell activities in vitro by Maliszewski, CR, Sato, TA, Vanden Bos, T, Waugh, S, Dower, SK, Slack, J, Beckmann, MP, Grabstein, KH

“…IL-1 and IL-4 are important mediators of B cell growth and differentiation. The cell-surface receptors for these cytokines have recently been cloned and…”
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