Search Results - "Beckham, Thomas H."

Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse by Cheng, Joseph C, Bai, Aiping, Beckham, Thomas H, Marrison, S Tucker, Yount, Caroline L, Young, Katherine, Lu, Ping, Bartlett, Anne M, Wu, Bill X, Keane, Barry J, Armeson, Kent E, Marshall, David T, Keane, Thomas E, Smith, Michael T, Jones, E Ellen, Drake, Jr, Richard R, Bielawska, Alicja, Norris, James S, Liu, Xiang

“…Escape of prostate cancer (PCa) cells from ionizing radiation-induced (IR-induced) killing leads to disease progression and cancer relapse. The influence of…”
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Intracranial meningiomas: an update of the 2021 World Health Organization classifications and review of management with a focus on radiation therapy by Yarabarla, Varun, Mylarapu, Amrutha, Han, Tatiana J, McGovern, Susan L, Raza, Shaan M, Beckham, Thomas H

“…Meningiomas account for approximately one third of all primary intracranial tumors. Arising from the cells of the arachnoid mater, these neoplasms are found…”
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Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling by Beckham, Thomas H, Cheng, Joseph C, Lu, Ping, Marrison, S Tucker, Norris, James S, Liu, Xiang

“…The tumor suppressor PTEN is now understood to regulate cellular processes at the cytoplasmic membrane, where it classically regulates PI3K signaling, as well…”
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LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria by Beckham, Thomas H, Lu, Ping, Jones, Elizabeth E, Marrison, Tucker, Lewis, Clayton S, Cheng, Joseph C, Ramshesh, Venkat K, Beeson, Gyda, Beeson, Craig C, Drake, Richard R, Bielawska, Alicja, Bielawski, Jacek, Szulc, Zdzislaw M, Ogretmen, Besim, Norris, James S, Liu, Xiang

“…Treatment of pancreatic cancer that cannot be surgically resected currently relies on minimally beneficial cytotoxic chemotherapy with gemcitabine. As the…”
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Acid Ceramidase Upregulation in Prostate Cancer Cells Confers Resistance to Radiation: AC Inhibition, a Potential Radiosensitizer by Mahdy, Ayman EM, Cheng, Joseph C, Li, Jun, Elojeimy, Saeed, Meacham, William D, Turner, Lorianne S, Bai, Aiping, Gault, Christopher R, McPherson, Alex S, Garcia, Nicole, Beckham, Thomas H, Saad, Antonio, Bielawska, Alicja, Bielawski, Jacek, Hannun, Yusuf A, Keane, Thomas E, Taha, Mohhammed I, Hammouda, Hisham M, Norris, James S, Liu, Xiang

“…Radiation resistance in a subset of prostate tumors remains a challenge to prostate cancer radiotherapy. The current study on the effects of radiation on…”
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Safety and efficacy of salvage conventional re-irradiation following stereotactic radiosurgery for spine metastases by Florez, Marcus A, De, Brian, Chapman, Bhavana V, Prayongrat, Anussara, Thomas, Jonathan G, Beckham, Thomas H, Wang, Chenyang, Yeboa, Debra N, Bishop, Andrew J, Briere, Tina, Amini, Behrang, Li, Jing, Tatsui, Claudio E, Rhines, Laurence D, Ghia, Amol J

“…There has been limited work assessing the use of re-irradiation (re-RT) for local failure following stereotactic spinal radiosurgery (SSRS). We reviewed our…”
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Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy by Liu, Xiang, Cheng, Joseph C, Turner, Lorianne S, Elojeimy, Saeed, Beckham, Thomas H, Bielawska, Alicja, Keane, Thomas E, Hannun, Yusuf A, Norris, James S

“…Bioactive sphingolipids, such as ceramide, sphingosine and sphingosine-1-phosphate are known bio-effector molecules which play important roles in various…”
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Metastasis-directed therapy for oligometastasis and beyond by Beckham, Thomas H., Yang, T. Jonathan, Gomez, Daniel, Tsai, C. Jillian

“…Metastasis-directed therapy (MDT)—local therapy that is intended to eradicate specific metastatic lesions—has hitherto been used with varying degrees of…”
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Long-term survival in patients with metastatic head and neck squamous cell carcinoma treated with metastasis-directed therapy by Beckham, Thomas H., Leeman, Jonathan E., Xie, Peng, Li, Xiaolin, Goldman, Debra A., Zhang, Zhigang, Sherman, Eric, McBride, Sean, Riaz, Nadeem, Lee, Nancy, Tsai, C. Jillian

“…Background Our objective was to evaluate the outcomes of metastatic head and neck squamous cell carcinoma (HNSCC) by disease burden with an emphasis on…”
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Targeting sphingolipid metabolism in head and neck cancer: rational therapeutic potentials by Beckham, Thomas H, Elojeimy, Saeed, Cheng, Joseph C, Turner, Lorianne S, Hoffman, Stanley R, Norris, James S, Liu, Xiang

“…Ceramide accumulation has been shown to be a conserved mechanism of apoptosis initiation in normal physiological processes as well as in response to cancer…”
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Validation of the prognostic index for spine metastasis (PRISM) for stratifying survival in patients treated with spinal stereotactic body radiation by Florez, Marcus A., De, Brian, Kowalchuk, Roman, Tang, Chad, Bishop, Andrew J., Kouzy, Ramez, Amini, Behrang, Briere, Tina, Beckham, Thomas H., Wang, Chenyang, Li, Jing, Tatsui, Claudio E., Rhines, Laurence D., Brown, Paul D., Merrell, Kenneth, Ghia, Amol J.

“…•The PRISM criteria uses patient characteristics to stratify patient prognosis following SSRS treatment.•PRISM can stratify OS in patients with diverse…”
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Treatment modalities and outcomes of Fanconi anemia patients with head and neck squamous cell carcinoma: Series of 9 cases and review of the literature by Beckham, Thomas H., Leeman, Jonathan, Jillian Tsai, Chiaojung, Riaz, Nadeem, Sherman, Eric, Singh, Bhuvanesh, Lee, Nancy, McBride, Sean, Higginson, Daniel S.

“…Background Fanconi anemia (FA) is associated with an increased risk of developing head and neck squamous cell cancer (HNSCC) and presents a treatment dilemma…”
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Salvage Stereotactic Radiosurgery for Recurrent WHO Grade 2 and 3 Meningiomas: A Multicenter Study (STORM) by Gallitto, Matthew, Sedor, Geoffrey, Lee, Albert, Pasetsky, Jared, Kinslow, Connor J., Santos, Genesis De Los, Obiri-Yeboah, Derrick, Kshettry, Varun R., Helis, Corbin A., Chan, Michael D., Beckham, Thomas H., McGovern, Susan L., Matsui, Jennifer, Palmer, Joshua D., Bell, Jonathan B., Mellon, Eric A., Lakomy, David, Huang, Jiayi, Boor, Ian, Rusthoven, Chad G., Sisti, Michael B., Wang, Tony J.C.

“…The role of stereotactic radiosurgery (SRS) in the management of grade 2 and 3 meningiomas is not well elucidated. Unfortunately, local recurrence rates are…”
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Definitive single fraction spine stereotactic radiosurgery for metastatic sarcoma: Simultaneous integrated boost is associated with high tumor control and low vertebral fracture risk by Shanker, Mihir D., Cavazos, Adriana P., Li, Jing, Beckham, Thomas H., Yeboa, Debra N., Wang, Chenyang, McAleer, Mary Frances, Briere, Tina Marie, Amini, Behrang, Tatsui, Claudio E., North, Robert Y., Alvarez-Breckenridge, Christopher A., Cezayirli, Phillip Cem, Rhines, Laurence D., Ghia, Amol J., Bishop, Andrew J.

“…Sarcoma spinal metastases (SSM) are particularly difficult to manage given their poor response rates to chemotherapy and inherent radioresistance. We evaluated…”
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Stereotactic radiosurgery for prostate cancer spine metastases: local control and fracture risk using a simultaneous integrated boost approach by Beckham, Thomas H, Rooney, Michael K, Cifter, Gizem, Bernard, Vincent, McAleer, Mary Frances, De, Brian S, Tom, Martin C, Perni, Subha, Wang, Chenyang, Swanson, Todd, Tatsui, Claudio E, Alvarez-Breckenridge, Christopher, North, Robert, Rhines, Laurence D, Tang, Chad, Logothetis, Christopher, Amini, Behrang, Li, Jing, Yeboa, Debra N, Ghia, Amol J

“…Variation exists in approaches to delivery of spine stereotactic radiosurgery (SSRS). Here, the authors describe outcomes following single-fraction SSRS…”
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Spinal laser interstitial thermal therapy and radiotherapy for thoracic metastatic epidural spinal cord compression by Tom, Martin C., Komatineni, Suraj, Wang, Chenyang, de Almeida, Romulo A. Andrade, Ghia, Amol J., Beckham, Thomas H., Perni, Subha, McAleer, Mary F., Swanson, Todd, Yeboa, Debra N., De, Brian S., Rooney, Michael K., Bishop, Andrew J., Reddy, Jay P., Yang, Yumeng, Ludmir, Ethan B., Zhang, Shizhen, Amini, Behrang, Alvarez-Breckenridge, Christopher, North, Robert Y., Rhines, Laurence D., Li, Jing, Tatsui, Claudio E.

“…Purpose Spinal laser interstitial thermal therapy (sLITT) is a less invasive alternative to surgery for metastatic epidural spinal cord compression. Here, we…”
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Brain Metastases from Biliary Tract Cancer: Case Series and Clinicogenomic Analysis by Dodoo, Grace N, De, Brian, Lee, Sunyoung S, Abi Jaoude, Joseph, Vauthey, Jean-Nicolas, Tzeng, Ching-Wei D, Tran Cao, Hop S, Katlowitz, Kalman A, Mandel, Jacob J, Beckham, Thomas H, Minsky, Bruce D, Smith, Grace L, Holliday, Emma B, Koong, Albert C, Das, Prajnan, Taniguchi, Cullen M, Javle, Milind, Koay, Eugene J, Ludmir, Ethan B

“…Abstract Background Limited data from small series have suggested that brain metastases from biliary tract cancers (BrM-BTC) affect ≤2% of patients with BTC…”
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Excellent Outcomes with Surgery or Radiotherapy in the Management of Castleman Disease Including a Case of Oligocentric Disease by Beckham, Thomas H., Yang, Joanna C., Chau, Karen W., Noy, Ariela, Yahalom, Joachim

“…Castleman disease (CD) is a rare polyclonal lymphoproliferative disorder of unclear etiology. Standard therapy for unicentric CD is surgical resection…”
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Platinum‐based regimens versus cetuximab in definitive chemoradiation for human papillomavirus‐unrelated head and neck cancer by Beckham, Thomas H., Barney, Christian, Healy, Erin, Wolfe, Adam R., Branstetter, Andrew, Yaney, Alexander, Riaz, Nadeem, McBride, Sean M., Tsai, C. Jillian, Kang, Julie, Yu, Yao, Chen, Linda, Sherman, Eric, Dunn, Lara, Pfister, David G., Tan, Jeremy, Rupert, Robert, Bonomi, Marcelo, Zhang, Zhigang, Lobaugh, Stephanie M., Grecula, John C., Mitchell, Darrion L., Wobb, Jessica L., Miller, Eric D., Blakaj, Dukagjin M., Diavolitsis, Virginia M., Lee, Nancy, Bhatt, Aashish D.

“…For patients ineligible for cisplatin with definitive radiotherapy (CP‐CRT) for locally advanced head and neck squamous cell carcinoma (LA‐HNSCC), concurrent…”
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Renal Function Outcomes of High-risk Neuroblastoma Patients Undergoing Radiation Therapy by Beckham, Thomas H., Casey, Dana L., LaQuaglia, Michael P., Kushner, Brian H., Modak, Shakeel, Wolden, Suzanne L.

“…To analyze the renal function outcomes in patients undergoing radiation therapy for neuroblastoma. The clinical metrics of renal function were analyzed in…”
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