Search Results - "Beckett, G J"

Myocardial infarction redefined: the new ACC/ESC definition, based on cardiac troponin, increases the apparent incidence of infarction by Ferguson, J L, Beckett, G J, Stoddart, M, Walker, S W, Fox, K A A

“…Objectives: To investigate the impact of the redefinition of the diagnostic criteria for myocardial infarction on its apparent incidence in a non-selected and…”
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First-line thyroid function tests − TSH alone is not enough by Beckett, G. J., Toft, A. D.

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Effects of selenium compounds on induction of DNA damage by broadband ultraviolet radiation in human keratinocytes by Rafferty, T.S., Green, M.H.L., Lowe, J.E., Arlett, C., Hunter, J.A.A., Beckett, G.J., McKenzie, R.C.

“…Summary Background Ultraviolet radiation (UVR), a ubiquitous environmental genotoxin for the skin, produces DNA damage. The trace element selenium induces…”
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Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in rats by Bermano, G, Nicol, F, Dyer, J A, Sunde, R A, Beckett, G J, Arthur, J R, Hesketh, J E

“…Regulation of synthesis of the selenoenzymes cytosolic glutathione peroxidase (GSH-Px), phospholipid hydroperoxide glutathione peroxidase (PHGSH-Px) and type-1…”
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Hepatic iodothyronine 5'-deiodinase. The role of selenium by Arthur, J R, Nicol, F, Beckett, G J

“…Selenium (Se) deficiency decreased by 8-fold the activity of type 1 iodothyronine 5'-deiodinase (ID-I) in hepatic microsomal fractions from rats. Solubilized…”
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New metabolic roles for selenium by ARTHUR, J. R, BECKETT, G. J

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Thyroid function by Arthur, John R, Beckett, Geoffrey J

“…Normal thyroid status is dependent on the presence of many trace elements for both the synthesis and metabolism of thyroid hormones. Iodine is most important…”
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Selenium protects primary human keratinocytes from apoptosis induced by exposure to ultraviolet radiation by Rafferty, T. S., Beckett, G. J., Walker, C., Bisset, Y. C., McKenzie, R. C.

“…Summary The generation of reactive oxygen species has been implicated in ultraviolet radiation (UVR)‐induced skin damage. In mice, increasing dietary selenium…”
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Selenium and iodine deficiencies: effects on brain and brown adipose tissue selenoenzyme activity and expression by Mitchell, JH, Nicol, F, Beckett, GJ, Arthur

“…Adequate dietary iodine supplies and thyroid hormones are needed for the development of the central nervous system (CNS) and brown adipose tissue (BAT)…”
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Inhibition of ultraviolet B radiation-induced interleukin 10 expression in murine keratinocytes by selenium compounds by Rafferty, T.S., Walker, C., Hunter, J.A.A., Beckett, G.J., Mckenzie, R.C.

“…Summary Background Selenium is an essential trace nutrient necessary for the normal function of the immune system. Selenium compounds protect mice against…”
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Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues by Howie, A F, Forrester, L M, Glancey, M J, Schlager, J J, Powis, G, Beckett, G J, Hayes, J D, Wolf, C R

“…Glutathione S-transferases play a central role in drug detoxification and have been implicated in the sensitivity of tumour cells to anticancer drugs. In this…”
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Glutathione S-transferases: biomedical applications by Beckett, G J, Hayes, J D

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Selenoprotein expression and brain development in preweanling selenium- and iodine-deficient rats by Mitchell, JH, Nicol, F, Beckett, GJ, Arthur

“…Selenium deficiency causes further impairment of thyroid hormone metabolism in iodine-deficient rats and therefore could have a role in the aetiology of both…”
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Predictors of treatment failure, incipient hypothyroidism, and weight gain following radioiodine therapy for Graves’ thyrotoxicosis by Gibb, F. W., Zammitt, N. N., Beckett, G. J., Strachan, M. W. J.

“…Background: Following radioiodine ( 131 I) therapy, both late recognition of hypothyroidism and treatment failure may result in adverse outcomes. Aim: We…”
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Glutathione S-transferase mu locus: use of genotyping and phenotyping assays to assess association with lung cancer susceptibility by Zhong, S, Howie, A F, Ketterer, B, Taylor, J, Hayes, J D, Beckett, G J, Wathen, C G, Wolf, C R, Spurr, N K

“…In mammals, the cytosolic glutathione S-transferases (GSTs; EC 2.5.1.18) are a supergene family comprised of four multigene families, named alpha, mu, pi and…”
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Effect of spinal anaesthesia on plasma concentrations of glutathione S-transferase by Ray, D.C., Robbins, A.G., Howie, A.F., Beckett, G.J., Drummond, G.B.

“…Plasma glutathione S-transferase (GST) concentration measurement is a sensitive and specific index of hepatocellular injury. GST concentration increases after…”
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Interlaboratory/intermethod differences in functional sensitivity of immunometric assays of thyrotropin (TSH) and impact on reliability of measurement of subnormal concentrations of TSH by Spencer, C A, Takeuchi, M, Kazarosyan, M, MacKenzie, F, Beckett, G J, Wilkinson, E

“…Clinically relevant interassay precision profiles for thyrotropin (thyroid-stimulating hormone; TSH) were constructed with human serum pools measured over 4-8…”
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The interactions between selenium and iodine deficiencies in man and animals by Arthur, John R, Beckett, Geoffrey J, Mitchell, Julie H

“…Up to one billion people live in areas where they may be at risk from I deficiency. Many of the debilitating effects of the deficiency may be irreversible,…”
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Identification of a 57-kilodalton selenoprotein in human thyrocytes as thioredoxin reductase and evidence that its expression is regulated through the calcium-phosphoinositol signaling pathway by HOWIE, A. F, ARTHUR, J. R, NICOL, F, WALKER, S. W, BEECH, S. G, BECKETT, G. J

“…Human thyrocytes incubated with the phorbol ester, phorbol 12-myristate 13-acetate (PMA; 10(-5)-10(-8) mol/L) and the calcium ionophore A23187 (10(-5)-10(-8)…”
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Selenoprotein expression in endothelial cells from different human vasculature and species by Miller, S, Walker, S.W, Arthur, J.R, Lewin, M.H, Pickard, K, Nicol, F, Howie, A.F, Beckett, G.J

“…Selenium (Se) can protect endothelial cells (EC) from oxidative damage by altering the expression of selenoproteins with antioxidant function such as…”
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