Search Results - "Beckett, Alex N"

Combinatorial CRISPR–Cas9 screens for de novo mapping of genetic interactions by Shen, John Paul, Zhao, Dongxin, Sasik, Roman, Luebeck, Jens, Birmingham, Amanda, Bojorquez-Gomez, Ana, Licon, Katherine, Klepper, Kristin, Pekin, Daniel, Beckett, Alex N, Sanchez, Kyle Salinas, Thomas, Alex, Kuo, Chih-Chung, Du, Dan, Roguev, Assen, Lewis, Nathan E, Chang, Aaron N, Kreisberg, Jason F, Krogan, Nevan, Qi, Lei, Ideker, Trey, Mali, Prashant

“…A library of plasmids expressing two gRNAs allows for the mapping of combinatorial genetic interactions with the CRISPR system. Results in cancer cells suggest…”
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A high-content screen of FDA approved drugs to enhance CAR T cell function: ingenol-3-angelate improves B7-H3-CAR T cell activity by upregulating B7-H3 on the target cell surface via PKCα activation by Lee, Ha Won, O'Reilly, Carla, Beckett, Alex N, Currier, Duane G, Chen, Taosheng, DeRenzo, Christopher

“…CAR T cell therapy is a promising approach to improve outcomes and decrease toxicities for patients with cancer. While extraordinary success has been achieved…”
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CD47 expression is critical for CAR T-cell survival in vivo by Beckett, Alex N, Chockley, Peter, Pruett-Miller, Shondra M, Nguyen, Phuong, Vogel, Peter, Sheppard, Heather, Krenciute, Giedre, Gottschalk, Stephen, DeRenzo, Christopher

“…BackgroundCD47 is an attractive immunotherapeutic target because it is highly expressed on multiple solid tumors. However, CD47 is also expressed on T cells…”
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Disruption of NSD1 in Head and Neck Cancer Promotes Favorable Chemotherapeutic Responses Linked to Hypomethylation by Bui, Nam, Huang, Justin K, Bojorquez-Gomez, Ana, Licon, Katherine, Sanchez, Kyle S, Tang, Sean N, Beckett, Alex N, Wang, Tina, Zhang, Wei, Shen, John Paul, Kreisberg, Jason F, Ideker, Trey

“…Human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) represents a distinct classification of cancer with worse expected outcomes…”
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A high-content screen of FDA approved drugs to enhance CAR T cell function: ingenol-3-angelate improves B7-H3-CAR T cell activity by upregulating B7-H3 on the target cell surface via PKC[alpha] activation by Lee, Ha Won, O'Reilly, Carla, Beckett, Alex N, Currier, Duane G, Chen, Taosheng, DeRenzo, Christopher

“…Background CAR T cell therapy is a promising approach to improve outcomes and decrease toxicities for patients with cancer. While extraordinary success has…”
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