Search Results - "Beckers, Pauline"

Implication of system xc− in neuroinflammation during the onset and maintenance of neuropathic pain by Beckers, Pauline, Belo Do Nascimento, Inês, Charlier, Mathilde, Desmet, Nathalie, Massie, Ann, Hermans, Emmanuel

“…Abstract Background Despite the high prevalence of neuropathic pain, treating this neurological disease remains challenging, given the limited efficacy and…”
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Modulation of Type 5 Metabotropic Glutamate Receptor-Mediated Intracellular Calcium Mobilization by Regulator of G Protein Signaling 4 (RGS4) in Cultured Astrocytes by Beckers, Pauline, Doyen, Pierre J, Hermans, Emmanuel

“…Acting as GTPase activating proteins promoting the silencing of activated G-proteins, regulators of G protein signaling (RGSs) are generally considered…”
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Validation of a System xc– Functional Assay in Cultured Astrocytes and Nervous Tissue Samples by Beckers, Pauline, Lara, Olaya, Belo do Nascimento, Ines, Desmet, Nathalie, Massie, Ann, Hermans, Emmanuel

“…Disruption of the glutamatergic homeostasis is commonly observed in neurological diseases and has been frequently correlated with the altered expression and/or…”
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AMPKα1 Deficiency in Astrocytes from a Rat Model of ALS Is Associated with an Altered Metabolic Resilience by Belo do Nascimento, Inês, Ates, Gamze, Desmet, Nathalie, Beckers, Pauline, Massie, Ann, Hermans, Emmanuel

“…Alterations in the activity of the regulator of cell metabolism AMP-activated protein kinase (AMPK) have been reported in motor neurons from patients and…”
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Structural investigation of human cystine/glutamate antiporter system xc− (Sxc−) using homology modeling and molecular dynamics by Hang, Tran Dieu, Hung, Huynh Minh, Beckers, Pauline, Desmet, Nathalie, Lamrani, Mohamed, Massie, Ann, Hermans, Emmanuel, Vanommeslaeghe, Kenno

“…The cystine/glutamate antiporter system x c − (Sx c − ) belongs to the SLC7 family of plasma membrane transporters. It exports intracellular glutamate along…”
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AMPK Modulates the Metabolic Adaptation of C6 Glioma Cells in Glucose-Deprived Conditions without Affecting Glutamate Transport by Belo do Nascimento, Inês, Verfaillie, Marie, Ates, Gamze, Beckers, Pauline, Joris, Virginie, Desmet, Nathalie, Massie, Ann, Hermans, Emmanuel

“…Energy homeostasis in the central nervous system largely depends on astrocytes, which provide metabolic support and protection to neurons. Astrocytes also…”
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β‐arrestin2 recruitment at the β2 adrenergic receptor: A luciferase complementation assay adapted for undergraduate training in pharmacology by Ferraiolo, Mattia, Beckers, Pauline, Marquet, Nicolas, Roumain, Martin, Ruiz, Lucie, Dupuis, Nadine, Hanson, Julien, Hermans, Emmanuel

“…In the context of pharmacology teaching, hands‐on activities constitute an essential complement to theoretical lectures. Frequently, these activities consist…”
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Regulators of G protein signalling as pharmacological targets for the treatment of neuropathic pain by Doyen, Pierre J., Beckers, Pauline, Brook, Gary A., Hermans, Emmanuel

“…[Display omitted] •RGS are essential modulators of GPCR signals•RGS expression is altered in diverse models of neuropathic pain•Manipulating RGS expression…”
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Receptor density influences ligand-induced dopamine D2L receptor homodimerization by Ferraiolo, Mattia, Atik, Hicham, Ponthot, Romane, Belo do Nascimento, Inês, Beckers, Pauline, Stove, Christophe, Hermans, Emmanuel

“…Chronic treatments with dopamine D2 receptor ligands induce fluctuations in D2 receptor density. Since D2 receptors tend to assemble as homodimers, we…”
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Implication of system x c - in neuroinflammation during the onset and maintenance of neuropathic pain by Beckers, Pauline, Belo Do Nascimento, Inês, Charlier, Mathilde, Desmet, Nathalie, Massie, Ann, Hermans, Emmanuel

“…Despite the high prevalence of neuropathic pain, treating this neurological disease remains challenging, given the limited efficacy and numerous side effects…”
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Compartmentalized role of xCT in supporting pancreatic tumor growth, inflammation and mood disturbance in mice by Lara, Olaya, Janssen, Pauline, Mambretti, Marco, De Pauw, Laura, Ates, Gamze, Mackens, Liselotte, De Munck, Jolien, Walckiers, Jarne, Pan, Zhaolong, Beckers, Pauline, Espinet, Elisa, Sato, Hideyo, De Ridder, Mark, Marks, Daniel L., Barbé, Kurt, Aerts, Joeri L., Hermans, Emmanuel, Rooman, Ilse, Massie, Ann

“…•Targeting xCT in the tumor is mandatory to reduce tumor size.•Deleting xCT only in the host reduces tumor-induced inflammation and immunosuppressive Treg…”
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Validation of a System x c - Functional Assay in Cultured Astrocytes and Nervous Tissue Samples by Beckers, Pauline, Lara, Olaya, Belo do Nascimento, Ines, Desmet, Nathalie, Massie, Ann, Hermans, Emmanuel

“…Disruption of the glutamatergic homeostasis is commonly observed in neurological diseases and has been frequently correlated with the altered expression and/or…”
Get full text

Lifespan extension with preservation of hippocampal function in aged system xc−-deficient male mice by Verbruggen, Lise, Ates, Gamze, Lara, Olaya, De Munck, Jolien, Villers, Agnès, De Pauw, Laura, Ottestad-Hansen, Sigrid, Kobayashi, Sho, Beckers, Pauline, Janssen, Pauline, Sato, Hideyo, Zhou, Yun, Hermans, Emmanuel, Njemini, Rose, Arckens, Lutgarde, Danbolt, Niels C., De Bundel, Dimitri, Aerts, Joeri L., Barbé, Kurt, Guillaume, Benoit, Ris, Laurence, Bentea, Eduard, Massie, Ann

“…The cystine/glutamate antiporter system x c − has been identified as the major source of extracellular glutamate in several brain regions as well as a…”
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Receptor density influences ligand-induced dopamine D 2L receptor homodimerization by Ferraiolo, Mattia, Atik, Hicham, Ponthot, Romane, Belo do Nascimento, Inês, Beckers, Pauline, Stove, Christophe, Hermans, Emmanuel

“…Chronic treatments with dopamine D2 receptor ligands induce fluctuations in D2 receptor density. Since D2 receptors tend to assemble as homodimers, we…”
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Structural investigation of human cystine/glutamate antiporter system x c - (Sx c - ) using homology modeling and molecular dynamics by Hang, Tran Dieu, Hung, Huynh Minh, Beckers, Pauline, Desmet, Nathalie, Lamrani, Mohamed, Massie, Ann, Hermans, Emmanuel, Vanommeslaeghe, Kenno

“…The cystine/glutamate antiporter system x (Sx ) belongs to the SLC7 family of plasma membrane transporters. It exports intracellular glutamate along the…”
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Lifespan extension with preservation of hippocampal function in aged system x c - -deficient male mice by Verbruggen, Lise, Ates, Gamze, Lara, Olaya, De Munck, Jolien, Villers, Agnès, De Pauw, Laura, Ottestad-Hansen, Sigrid, Kobayashi, Sho, Beckers, Pauline, Janssen, Pauline, Sato, Hideyo, Zhou, Yun, Hermans, Emmanuel, Njemini, Rose, Arckens, Lutgarde, Danbolt, Niels C, De Bundel, Dimitri, Aerts, Joeri L, Barbé, Kurt, Guillaume, Benoit, Ris, Laurence, Bentea, Eduard, Massie, Ann

“…The cystine/glutamate antiporter system x has been identified as the major source of extracellular glutamate in several brain regions as well as a modulator of…”
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